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- Tranilast abstract "Tranilast (INN, brand name Rizaben) is an antiallergic drug. It was developed by Kissei Pharmaceuticals and was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.In-vitro it reduces collagen synthesis in fibroblasts, and inhibits growth of neurofibroma cells.In-vitro it inhibits the production of interleukin-6 in endothelial cells.It is relatively safe and well tolerated by most patients at doses of up to 600 mg/day for months. After promising results in three small trial Tranilast was studied in a major clinical trial (the PRESTO trial) for prevention of restenosis after percutaneous transluminal coronary revascularization, but was not found effective for that application.It has also been investigated for use as an antiproliferative drug on drug-eluting stents.A phase II trial is recruiting rheumatoid arthritis patients.A phase III trial is evaluating tranilast for Pterygium.".
- Tranilast atcPrefix "none".
- Tranilast casNumber "53902-12-8".
- Tranilast chEBI "77572".
- Tranilast fdaUniiCode "HVF50SMY6E".
- Tranilast iupacName "2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2- enoyl]amino}benzoic acid".
- Tranilast pubchem "5282230".
- Tranilast thumbnail Tranilast.svg?width=300.
- Tranilast wikiPageExternalLink Chemical-Structure.4445411.html.
- Tranilast wikiPageID "18592225".
- Tranilast wikiPageLength "3795".
- Tranilast wikiPageOutDegree "23".
- Tranilast wikiPageRevisionID "679770028".
- Tranilast wikiPageWikiLink Allergic_rhinitis.
- Tranilast wikiPageWikiLink Antiproliferative.
- Tranilast wikiPageWikiLink Asthma.
- Tranilast wikiPageWikiLink Atopic_dermatitis.
- Tranilast wikiPageWikiLink Bronchial_asthma.
- Tranilast wikiPageWikiLink Category:Alkenes.
- Tranilast wikiPageWikiLink Category:Amides.
- Tranilast wikiPageWikiLink Category:Anthranilic_acids.
- Tranilast wikiPageWikiLink Category:Antiasthmatic_drugs.
- Tranilast wikiPageWikiLink Category:Phenol_ethers.
- Tranilast wikiPageWikiLink Cytostasis.
- Tranilast wikiPageWikiLink Drug-eluting_stent.
- Tranilast wikiPageWikiLink Endothelial_cell.
- Tranilast wikiPageWikiLink Endothelium.
- Tranilast wikiPageWikiLink Fibroblast.
- Tranilast wikiPageWikiLink Fibroblasts.
- Tranilast wikiPageWikiLink Hypertrophic_scar.
- Tranilast wikiPageWikiLink Interleukin-6.
- Tranilast wikiPageWikiLink Interleukin_6.
- Tranilast wikiPageWikiLink International_Nonproprietary_Name.
- Tranilast wikiPageWikiLink Keloid.
- Tranilast wikiPageWikiLink Keloid_scar.
- Tranilast wikiPageWikiLink Neurofibroma.
- Tranilast wikiPageWikiLink PRESTO_trial.
- Tranilast wikiPageWikiLink Percutaneous_coronary_intervention.
- Tranilast wikiPageWikiLink Pterygium.
- Tranilast wikiPageWikiLink Restenosis.
- Tranilast wikiPageWikiLink Rheumatoid_arthritis.
- Tranilast wikiPageWikiLinkText "Tranilast".
- Tranilast wikiPageWikiLinkText "tranilast".
- Tranilast atcPrefix "none".
- Tranilast c "18".
- Tranilast casNumber "53902".
- Tranilast chebi "77572".
- Tranilast chembl "415324".
- Tranilast h "17".
- Tranilast hasPhotoCollection Tranilast.
- Tranilast iupacName "2".
- Tranilast iupharLigand "6326".
- Tranilast legalStatus "Rx-only".
- Tranilast molecularWeight "327.33".
- Tranilast n "1".
- Tranilast o "5".
- Tranilast pubchem "5282230".
- Tranilast routesOfAdministration "Oral".
- Tranilast smiles "COC1=COC".
- Tranilast stdinchi "1".
- Tranilast stdinchikey "NZHGWWWHIYHZNX-CSKARUKUSA-N".
- Tranilast unii "HVF50SMY6E".
- Tranilast wikiPageUsesTemplate Template:Drugbox.
- Tranilast wikiPageUsesTemplate Template:Reflist.
- Tranilast wikiPageUsesTemplate Template:Respiratory-system-drug-stub.
- Tranilast subject Category:Alkenes.
- Tranilast subject Category:Amides.
- Tranilast subject Category:Anthranilic_acids.
- Tranilast subject Category:Antiasthmatic_drugs.
- Tranilast subject Category:Phenol_ethers.
- Tranilast hypernym Drug.
- Tranilast type Article.
- Tranilast type ChemicalSubstance.
- Tranilast type Drug.
- Tranilast type Group.
- Tranilast type Alkene.
- Tranilast type Amide.
- Tranilast type Article.
- Tranilast type Chemical.
- Tranilast type Drug.
- Tranilast type Ether.
- Tranilast type Group.
- Tranilast type Hydrocarbon.
- Tranilast type ChemicalObject.
- Tranilast type Thing.
- Tranilast type Q8386.
- Tranilast comment "Tranilast (INN, brand name Rizaben) is an antiallergic drug. It was developed by Kissei Pharmaceuticals and was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993.".
- Tranilast label "Tranilast".
- Tranilast sameAs Tranilast.
- Tranilast sameAs Tranilast.
- Tranilast sameAs m.04f_vcx.
- Tranilast sameAs Tranilast.
- Tranilast sameAs Tranilast.
- Tranilast sameAs Q2325594.
- Tranilast sameAs Q2325594.
- Tranilast wasDerivedFrom Tranilast?oldid=679770028.
- Tranilast depiction Tranilast.svg.
- Tranilast isPrimaryTopicOf Tranilast.