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- Tetrad_test abstract "The tetrad test is a series of behavioral paradigms in which rodents treated with cannabinoids such as THC show effects. It is widely used for screening drugs that induce cannabinoid receptor-mediated effects in rodents. The four behavioral components of the tetrad are spontaneous activity, catalepsy, hypothermia, and analgesia. Common assays for these behavioral paradigms are as follows: Spontaneous activity (or hypomotility) is determined by an open field test, in which a mouse is placed in a cage with perpendicular grid lines, usually spaced by approx. 1 inch. An experimenter counts the number of line crossings by the mouse in a given amount of time. Catalepsy is determined by the bar test. The mouse is placed on a bar oriented parallel to and approximately 1 inch off of the ground. If the mouse remains immobile on the bar for typically more than 20 seconds, it is considered cataleptic. Hypothermia is determined by using a rectal probe to measure the rectal temperature. Analgesia is usually determined by the hot plate or tail immersion test. In the hot plate test, the mouse is placed on a heated plate, typically between 54 and 58°C. An experimenter measures the time it takes for the mouse to jump off of the hot plate. In the tail immersion test, the mouse is immobilized and its tail is placed into a warm water bath, typically also between 54 and 58°C. An experimenter measures the time it takes for the mouse to remove its tail from the water bath.Direct CB1 agonists, such as THC (the psychoactive component of marijuana), or WIN 55,212-2, have effects in all components of the tetrad and induce hypomotility, catalepsy, hypothermia, and analgesia in rodents. Accordingly, all true "tetrad effects" are not observed following treatment with antagonists of CB1 such as rimonabant.".
- Tetrad_test wikiPageID "18792968".
- Tetrad_test wikiPageLength "2286".
- Tetrad_test wikiPageOutDegree "16".
- Tetrad_test wikiPageRevisionID "443471240".
- Tetrad_test wikiPageWikiLink Analgesia.
- Tetrad_test wikiPageWikiLink Analgesic.
- Tetrad_test wikiPageWikiLink Cannabinoid.
- Tetrad_test wikiPageWikiLink Cannabinoid_receptor.
- Tetrad_test wikiPageWikiLink Cannabinoid_receptor_1.
- Tetrad_test wikiPageWikiLink Cannabinoid_receptor_type_1.
- Tetrad_test wikiPageWikiLink Cannabinoids.
- Tetrad_test wikiPageWikiLink Cannabis_(drug).
- Tetrad_test wikiPageWikiLink Catalepsy.
- Tetrad_test wikiPageWikiLink Category:Behavioral_concepts.
- Tetrad_test wikiPageWikiLink Category:Cannabinoids.
- Tetrad_test wikiPageWikiLink Category:Neuropsychology.
- Tetrad_test wikiPageWikiLink Hypomotility.
- Tetrad_test wikiPageWikiLink Hypothermia.
- Tetrad_test wikiPageWikiLink Marijuana.
- Tetrad_test wikiPageWikiLink Motility.
- Tetrad_test wikiPageWikiLink Receptor_antagonist.
- Tetrad_test wikiPageWikiLink Rimonabant.
- Tetrad_test wikiPageWikiLink THC.
- Tetrad_test wikiPageWikiLink Tetrahydrocannabinol.
- Tetrad_test wikiPageWikiLink WIN_55,212-2.
- Tetrad_test wikiPageWikiLinkText "cannabinoid-related behavioral effects".
- Tetrad_test wikiPageWikiLinkText "tetrad assay".
- Tetrad_test hasPhotoCollection Tetrad_test.
- Tetrad_test wikiPageUsesTemplate Template:Psych-stub.
- Tetrad_test wikiPageUsesTemplate Template:Refimprove.
- Tetrad_test wikiPageUsesTemplate Template:Reflist.
- Tetrad_test subject Category:Behavioral_concepts.
- Tetrad_test subject Category:Cannabinoids.
- Tetrad_test subject Category:Neuropsychology.
- Tetrad_test hypernym Series.
- Tetrad_test type Article.
- Tetrad_test type Drug.
- Tetrad_test type TelevisionShow.
- Tetrad_test type Article.
- Tetrad_test type Cannabinoid.
- Tetrad_test type Concept.
- Tetrad_test type Drug.
- Tetrad_test comment "The tetrad test is a series of behavioral paradigms in which rodents treated with cannabinoids such as THC show effects. It is widely used for screening drugs that induce cannabinoid receptor-mediated effects in rodents. The four behavioral components of the tetrad are spontaneous activity, catalepsy, hypothermia, and analgesia.".
- Tetrad_test label "Tetrad test".
- Tetrad_test sameAs m.04gnwy8.
- Tetrad_test sameAs Q7706307.
- Tetrad_test sameAs Q7706307.
- Tetrad_test wasDerivedFrom Tetrad_test?oldid=443471240.
- Tetrad_test isPrimaryTopicOf Tetrad_test.