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- Tebanicline abstract "Tebanicline (Ebanicline, ABT-594) is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound.Tebanicline got as far as Phase II trials in humans, but was dropped from further development due to unacceptable incidence of gastrointestinal side effects. However further research in this area is ongoing, and it is expected that development of new neural nicotinic acetylcholine receptor agonists will be likely to lead to novel analgesics suitable for use in humans within the next few years.It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes.".
- Tebanicline atcPrefix "none".
- Tebanicline casNumber "198283-73-7".
- Tebanicline fdaUniiCode "9KX8NKV538".
- Tebanicline iupacName "5-([(2R)-Azetidin-2-yl]methoxy)-2-chloropyridine".
- Tebanicline pubchem "3075702".
- Tebanicline thumbnail Tebaniciclina.png?width=300.
- Tebanicline wikiPageID "17712648".
- Tebanicline wikiPageLength "12302".
- Tebanicline wikiPageOutDegree "19".
- Tebanicline wikiPageRevisionID "678202359".
- Tebanicline wikiPageWikiLink Abbott_Laboratories.
- Tebanicline wikiPageWikiLink Alpha-4_beta-2_nicotinic_receptor.
- Tebanicline wikiPageWikiLink Analgesic.
- Tebanicline wikiPageWikiLink Category:Analgesics.
- Tebanicline wikiPageWikiLink Category:Azetidines.
- Tebanicline wikiPageWikiLink Category:Chloroarenes.
- Tebanicline wikiPageWikiLink Category:Nicotinic_agonists.
- Tebanicline wikiPageWikiLink Category:Phenol_ethers.
- Tebanicline wikiPageWikiLink Category:Pyridines.
- Tebanicline wikiPageWikiLink Category:Stimulants.
- Tebanicline wikiPageWikiLink Epibatidine.
- Tebanicline wikiPageWikiLink Ganglion_type_nicotinic_receptor.
- Tebanicline wikiPageWikiLink Gastrointestinal.
- Tebanicline wikiPageWikiLink Human_gastrointestinal_tract.
- Tebanicline wikiPageWikiLink Morphine.
- Tebanicline wikiPageWikiLink Neuropathic_pain.
- Tebanicline wikiPageWikiLink Nicotinic_acetylcholine_receptor.
- Tebanicline wikiPageWikiLink Partial_agonist.
- Tebanicline wikiPageWikiLink Poison_dart_frog.
- Tebanicline wikiPageWikiLinkText "Tebanicline".
- Tebanicline atcPrefix "none".
- Tebanicline c "9".
- Tebanicline casNumber "198283".
- Tebanicline chembl "430497".
- Tebanicline chemspiderid "2334347".
- Tebanicline cl "1".
- Tebanicline h "11".
- Tebanicline hasPhotoCollection Tebanicline.
- Tebanicline inchi "1".
- Tebanicline inchikey "MKTAGSRKQIGEBH-SSDOTTSWBL".
- Tebanicline iupacName "5".
- Tebanicline iupharLigand "3989".
- Tebanicline molecularWeight "198.649".
- Tebanicline n "2".
- Tebanicline o "1".
- Tebanicline pubchem "3075702".
- Tebanicline smiles "C1CN[C@H]1COC2=CN=CCl".
- Tebanicline stdinchi "1".
- Tebanicline stdinchikey "MKTAGSRKQIGEBH-SSDOTTSWSA-N".
- Tebanicline unii "9".
- Tebanicline verifiedfields "changed".
- Tebanicline verifiedrevid "448113374".
- Tebanicline watchedfields "changed".
- Tebanicline width "240".
- Tebanicline wikiPageUsesTemplate Template:Analgesic-stub.
- Tebanicline wikiPageUsesTemplate Template:Analgesics.
- Tebanicline wikiPageUsesTemplate Template:Cholinergics.
- Tebanicline wikiPageUsesTemplate Template:Drugbox.
- Tebanicline wikiPageUsesTemplate Template:Nootropics.
- Tebanicline wikiPageUsesTemplate Template:Reflist.
- Tebanicline wikiPageUsesTemplate Template:Stimulants.
- Tebanicline subject Category:Analgesics.
- Tebanicline subject Category:Azetidines.
- Tebanicline subject Category:Chloroarenes.
- Tebanicline subject Category:Nicotinic_agonists.
- Tebanicline subject Category:Phenol_ethers.
- Tebanicline subject Category:Pyridines.
- Tebanicline subject Category:Stimulants.
- Tebanicline hypernym Drug.
- Tebanicline type Article.
- Tebanicline type ChemicalSubstance.
- Tebanicline type Drug.
- Tebanicline type Agonist.
- Tebanicline type Analgesic.
- Tebanicline type Article.
- Tebanicline type Chemical.
- Tebanicline type Drug.
- Tebanicline type Ether.
- Tebanicline type Heterocycle.
- Tebanicline type Organohalide.
- Tebanicline type Parasympathomimetic.
- Tebanicline type Psychoanaleptic.
- Tebanicline type Stimulant.
- Tebanicline type Organohalide.
- Tebanicline type ChemicalObject.
- Tebanicline type Thing.
- Tebanicline type Q8386.
- Tebanicline comment "Tebanicline (Ebanicline, ABT-594) is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects.".
- Tebanicline label "Tebanicline".
- Tebanicline sameAs Tebaniciclina.
- Tebanicline sameAs m.047dv_7.
- Tebanicline sameAs Tebaniklin.
- Tebanicline sameAs Tebaniklin.
- Tebanicline sameAs Q7692017.
- Tebanicline sameAs Q7692017.
- Tebanicline wasDerivedFrom Tebanicline?oldid=678202359.
- Tebanicline depiction Tebaniciclina.png.
- Tebanicline isPrimaryTopicOf Tebanicline.