Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/T-type_calcium_channel> ?p ?o }
- T-type_calcium_channel abstract "T-type calcium channels are low-voltage activated calcium channels that open during membrane depolarization. These channels aid in mediating calcium influx into cells after an action potential or depolarizing signal. The entry of calcium into various cells has many different physiological responses associated with it. Within cardiac and smooth muscle cells voltage-gated calcium channel activation initiates contraction directly by allowing the cytosolic calcium concentration to increase. Not only are T-type calcium channels known to be present within cardiac and smooth muscle, but also are present in many neuronal cells within the central nervous system. Different experimental studies within the 1970s allowed for the distinction of T-type calcium channels (transient opening calcium channels) from the already well-known L-type calcium channels (Long-Lasting calcium channels). The new T-type channels were much different from the L-type calcium channels due to their ability to be activated by more negative membrane potentials, had small single channel conductance, and also were unresponsive to calcium antagonist drugs that were present. These distinct calcium channels are generally located within the brain, peripheral nervous system, heart, smooth muscle, bone, and endocrine system.The distinct structures of T-type calcium channels are what allow them to conduct in these manners, consisting of a primary α1 subunit. The α1 subunit of T-type channels is the primary subunit that forms the pore of the channel, and allows for entry of calcium.T-type calcium channels function to control the pace-making activity of the SA Node within the heart and relay rapid action potentials within the thalamus. These channels allow for continuous rhythmic bursts that control the SA Node of the heart.Pharmacological evidence of T-type calcium channels suggest that they play a key role in diseases such as absence epilepsy, diabetes, and several forms of cancer. Further research is continuously occurring to better understand these distinct channels, as well as create drugs to select for these channels.".
- T-type_calcium_channel arm "p".
- T-type_calcium_channel arm "q".
- T-type_calcium_channel band "13.1".
- T-type_calcium_channel band "13.3".
- T-type_calcium_channel band "22".
- T-type_calcium_channel chromosome "16".
- T-type_calcium_channel chromosome "17".
- T-type_calcium_channel chromosome "22".
- T-type_calcium_channel entrezgene "8911".
- T-type_calcium_channel entrezgene "8912".
- T-type_calcium_channel hgncid "1394".
- T-type_calcium_channel hgncid "1395".
- T-type_calcium_channel hgncid "1396".
- T-type_calcium_channel omim "604065".
- T-type_calcium_channel omim "607904".
- T-type_calcium_channel omim "608230".
- T-type_calcium_channel refseq "NM_001003406".
- T-type_calcium_channel refseq "NM_001005407".
- T-type_calcium_channel refseq "NM_018896".
- T-type_calcium_channel symbol "CACNA1G".
- T-type_calcium_channel symbol "CACNA1H".
- T-type_calcium_channel symbol "CACNA1I".
- T-type_calcium_channel uniprot "O43497".
- T-type_calcium_channel uniprot "O95180".
- T-type_calcium_channel uniprot "Q9P0X4".
- T-type_calcium_channel wikiPageID "9773346".
- T-type_calcium_channel wikiPageLength "15101".
- T-type_calcium_channel wikiPageOutDegree "42".
- T-type_calcium_channel wikiPageRevisionID "674790234".
- T-type_calcium_channel wikiPageWikiLink Absence_epilepsy.
- T-type_calcium_channel wikiPageWikiLink Absence_seizure.
- T-type_calcium_channel wikiPageWikiLink Angiotensin.
- T-type_calcium_channel wikiPageWikiLink Antagonist.
- T-type_calcium_channel wikiPageWikiLink CACNA1G.
- T-type_calcium_channel wikiPageWikiLink CACNA1H.
- T-type_calcium_channel wikiPageWikiLink CACNA1I.
- T-type_calcium_channel wikiPageWikiLink Calcium.
- T-type_calcium_channel wikiPageWikiLink Calcium_channel_blocker.
- T-type_calcium_channel wikiPageWikiLink Calcium_channel_blockers.
- T-type_calcium_channel wikiPageWikiLink Calcium_ion.
- T-type_calcium_channel wikiPageWikiLink Cancer.
- T-type_calcium_channel wikiPageWikiLink Cancer_stem_cell.
- T-type_calcium_channel wikiPageWikiLink Cancer_stem_cells.
- T-type_calcium_channel wikiPageWikiLink Cell_cycle.
- T-type_calcium_channel wikiPageWikiLink Cell_cycle_progression.
- T-type_calcium_channel wikiPageWikiLink Clinical_trial.
- T-type_calcium_channel wikiPageWikiLink Cytostasis.
- T-type_calcium_channel wikiPageWikiLink Cytostatic.
- T-type_calcium_channel wikiPageWikiLink Cytotoxic_effects.
- T-type_calcium_channel wikiPageWikiLink Cytotoxicity.
- T-type_calcium_channel wikiPageWikiLink Depolarization.
- T-type_calcium_channel wikiPageWikiLink Diabetes.
- T-type_calcium_channel wikiPageWikiLink Diabetes_mellitus.
- T-type_calcium_channel wikiPageWikiLink Diabetic_neuropathy.
- T-type_calcium_channel wikiPageWikiLink Dopamine.
- T-type_calcium_channel wikiPageWikiLink Glioma.
- T-type_calcium_channel wikiPageWikiLink Gliomas.
- T-type_calcium_channel wikiPageWikiLink Insulinoma.
- T-type_calcium_channel wikiPageWikiLink L-type_calcium_channel.
- T-type_calcium_channel wikiPageWikiLink L-type_calcium_channels.
- T-type_calcium_channel wikiPageWikiLink Leukemia.
- T-type_calcium_channel wikiPageWikiLink Melanoma.
- T-type_calcium_channel wikiPageWikiLink Mibefradil.
- T-type_calcium_channel wikiPageWikiLink Neuropathic_pain.
- T-type_calcium_channel wikiPageWikiLink Nociceptor.
- T-type_calcium_channel wikiPageWikiLink Nociceptors.
- T-type_calcium_channel wikiPageWikiLink Peripheral_diabetic_neuropathy.
- T-type_calcium_channel wikiPageWikiLink Potassium.
- T-type_calcium_channel wikiPageWikiLink Potassium_ion.
- T-type_calcium_channel wikiPageWikiLink Reticular_nucleus_of_the_thalamus.
- T-type_calcium_channel wikiPageWikiLink Retinoblastoma.
- T-type_calcium_channel wikiPageWikiLink Sinoatrial_node.
- T-type_calcium_channel wikiPageWikiLink Sodium.
- T-type_calcium_channel wikiPageWikiLink Sodium_channel.
- T-type_calcium_channel wikiPageWikiLink Sodium_channels.
- T-type_calcium_channel wikiPageWikiLink Sodium_ion.
- T-type_calcium_channel wikiPageWikiLink Sympathetic_nervous_system.
- T-type_calcium_channel wikiPageWikiLink Thalamic_reticular_nucleus.
- T-type_calcium_channel wikiPageWikiLink Thalamus.
- T-type_calcium_channel wikiPageWikiLink Voltage-dependent_calcium_channel.
- T-type_calcium_channel wikiPageWikiLink Voltage-gated_calcium_channels.
- T-type_calcium_channel wikiPageWikiLink Voltage-gated_ion_channel.
- T-type_calcium_channel wikiPageWikiLinkText "T-type calcium channel".
- T-type_calcium_channel wikiPageWikiLinkText "T-type channels".
- T-type_calcium_channel wikiPageWikiLinkText "T-type".
- T-type_calcium_channel wikiPageWikiLinkText "low-voltage activated".
- T-type_calcium_channel arm "p".
- T-type_calcium_channel arm "q".
- T-type_calcium_channel band "13.1".
- T-type_calcium_channel band "13.3".
- T-type_calcium_channel band "22".
- T-type_calcium_channel chromosome "16".
- T-type_calcium_channel chromosome "17".
- T-type_calcium_channel chromosome "22".
- T-type_calcium_channel entrezgene "8911".
- T-type_calcium_channel entrezgene "8912".
- T-type_calcium_channel hasPhotoCollection T-type_calcium_channel.
- T-type_calcium_channel hgncid "1394".
- T-type_calcium_channel hgncid "1395".