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- Synaptic_gating abstract "Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.".
- Synaptic_gating thumbnail Gatekeeping.png?width=300.
- Synaptic_gating wikiPageID "9916386".
- Synaptic_gating wikiPageLength "24393".
- Synaptic_gating wikiPageOutDegree "40".
- Synaptic_gating wikiPageRevisionID "663534328".
- Synaptic_gating wikiPageWikiLink ADHD.
- Synaptic_gating wikiPageWikiLink AMPA_receptor.
- Synaptic_gating wikiPageWikiLink AND_gate.
- Synaptic_gating wikiPageWikiLink Action_potential.
- Synaptic_gating wikiPageWikiLink Amygdala.
- Synaptic_gating wikiPageWikiLink Artificial_neural_network.
- Synaptic_gating wikiPageWikiLink Attention_deficit_hyperactivity_disorder.
- Synaptic_gating wikiPageWikiLink Attentional_control.
- Synaptic_gating wikiPageWikiLink Auditory_cortex.
- Synaptic_gating wikiPageWikiLink Basal_ganglia.
- Synaptic_gating wikiPageWikiLink Category:Neuroscience.
- Synaptic_gating wikiPageWikiLink Cerebral_cortex.
- Synaptic_gating wikiPageWikiLink Child_Behavior_Checklist.
- Synaptic_gating wikiPageWikiLink Depolarization.
- Synaptic_gating wikiPageWikiLink Dopamine.
- Synaptic_gating wikiPageWikiLink EPSP.
- Synaptic_gating wikiPageWikiLink Electronic_circuit.
- Synaptic_gating wikiPageWikiLink Entorhinal_cortex.
- Synaptic_gating wikiPageWikiLink Excitatory_postsynaptic_potential.
- Synaptic_gating wikiPageWikiLink GABA.
- Synaptic_gating wikiPageWikiLink Gamma-Aminobutyric_acid.
- Synaptic_gating wikiPageWikiLink Gate_theory_of_pain.
- Synaptic_gating wikiPageWikiLink Hyperpolarization_(biology).
- Synaptic_gating wikiPageWikiLink Medial_prefrontal_cortex.
- Synaptic_gating wikiPageWikiLink Mesolimbic_pathway.
- Synaptic_gating wikiPageWikiLink Methylphenidate.
- Synaptic_gating wikiPageWikiLink NMDA_receptor.
- Synaptic_gating wikiPageWikiLink Neural_network.
- Synaptic_gating wikiPageWikiLink Neuromodulation.
- Synaptic_gating wikiPageWikiLink Neuromodulation_(biology).
- Synaptic_gating wikiPageWikiLink Neuron.
- Synaptic_gating wikiPageWikiLink Nucleus_accumbens.
- Synaptic_gating wikiPageWikiLink Pain.
- Synaptic_gating wikiPageWikiLink Positive_reinforcer.
- Synaptic_gating wikiPageWikiLink Prefrontal_cortex.
- Synaptic_gating wikiPageWikiLink Reinforcement.
- Synaptic_gating wikiPageWikiLink Resting_membrane_potential.
- Synaptic_gating wikiPageWikiLink Resting_potential.
- Synaptic_gating wikiPageWikiLink Selective_attention.
- Synaptic_gating wikiPageWikiLink Shunting_inhibition.
- Synaptic_gating wikiPageWikiLink Summation.
- Synaptic_gating wikiPageWikiLink Synapse.
- Synaptic_gating wikiPageWikiLink Thalamus.
- Synaptic_gating wikiPageWikiLink Threshold_potential.
- Synaptic_gating wikiPageWikiLink Transistor.
- Synaptic_gating wikiPageWikiLink Ventral_tegmental_area.
- Synaptic_gating wikiPageWikiLink File:Gatekeeping.png.
- Synaptic_gating wikiPageWikiLink File:Transistor_BJT.png.
- Synaptic_gating wikiPageWikiLinkText "Synaptic gating".
- Synaptic_gating wikiPageWikiLinkText "synaptic gating".
- Synaptic_gating hasPhotoCollection Synaptic_gating.
- Synaptic_gating wikiPageUsesTemplate Template:Main.
- Synaptic_gating wikiPageUsesTemplate Template:Reflist.
- Synaptic_gating subject Category:Neuroscience.
- Synaptic_gating hypernym Ability.
- Synaptic_gating type Disease.
- Synaptic_gating comment "Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output.".
- Synaptic_gating label "Synaptic gating".
- Synaptic_gating sameAs m.02pwyw0.
- Synaptic_gating sameAs Q17163361.
- Synaptic_gating sameAs Q17163361.
- Synaptic_gating wasDerivedFrom Synaptic_gating?oldid=663534328.
- Synaptic_gating depiction Gatekeeping.png.
- Synaptic_gating isPrimaryTopicOf Synaptic_gating.