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- Semliki_Forest_virus abstract "The Semliki Forest virus was first isolated from mosquitoes in the Semliki Forest, Uganda by the Uganda Virus Research Institute in 1942 and described by Smithburn & Haddow. It is known to cause disease in both animals and humans. It is an Alphavirus found in central, eastern, and southern Africa.The Semliki Forest virus is a positive-stranded RNA virus with a genome of approximately 13,000 base pairs which encodes nine proteins. The 5’ two thirds of the genome encode four non-structural proteins concerned with RNA synthesis and the structural proteins are encoded in the 3’ third. Of the structural proteins, the C proteins makes up the icosahedral capsid which is enveloped by a lipid bilayer, derived from the host cell. The outermost surface of the virus is almost entirely covered by heterodimers of glycoproteins E1 and E2, arranged in interconnective trimers, which form an outer shell. Trimers are anchored in the membrane by an E2 cytoplasmic domain that associates with the nucleocapsid.Replication occurs via a negative strand intermediate giving rise to a full length genomic RNA for export in new virions and a subgenomic message that is translated into the structural proteins.Semliki Forest virus is spread mainly by mosquito bites. It is not able to infect mammals through inhalation or gastrointestinal exposure, although rodents in the laboratory can be infected by intranasal instillation. The virus is able to cause a lethal encephalitis in rodents, but generally only mild symptoms in humans. Only one lethal human infection has been reported. In this one case, the patient was speculated to be immunodeficient and potentially had been exposed to large amounts of virus in the laboratory.Semliki Forest virus has been used extensively in biological research as a model of the viral life cycle and of viral neuropathy. Due to its broad host range and efficient replication, it has also been developed as a vector for genes encoding vaccines and anti-cancer agents, and as a tool in gene therapy.".
- Semliki_Forest_virus family Togaviridae.
- Semliki_Forest_virus genus Alphavirus.
- Semliki_Forest_virus thumbnail Semliki-Forest-Virus.jpg?width=300.
- Semliki_Forest_virus wikiPageID "2052681".
- Semliki_Forest_virus wikiPageLength "6699".
- Semliki_Forest_virus wikiPageOutDegree "30".
- Semliki_Forest_virus wikiPageRevisionID "678169354".
- Semliki_Forest_virus wikiPageWikiLink Africa.
- Semliki_Forest_virus wikiPageWikiLink Alphavirus.
- Semliki_Forest_virus wikiPageWikiLink Base_pair.
- Semliki_Forest_virus wikiPageWikiLink Cancer.
- Semliki_Forest_virus wikiPageWikiLink Capsid.
- Semliki_Forest_virus wikiPageWikiLink Category:Alphaviruses.
- Semliki_Forest_virus wikiPageWikiLink Chikungunya.
- Semliki_Forest_virus wikiPageWikiLink Digestion.
- Semliki_Forest_virus wikiPageWikiLink Encephalitis.
- Semliki_Forest_virus wikiPageWikiLink Gastrointestinal_tract.
- Semliki_Forest_virus wikiPageWikiLink Gene.
- Semliki_Forest_virus wikiPageWikiLink Gene_therapy.
- Semliki_Forest_virus wikiPageWikiLink Genome.
- Semliki_Forest_virus wikiPageWikiLink Glycoprotein.
- Semliki_Forest_virus wikiPageWikiLink Glycoproteins.
- Semliki_Forest_virus wikiPageWikiLink Icosahedral.
- Semliki_Forest_virus wikiPageWikiLink Immunodeficiency.
- Semliki_Forest_virus wikiPageWikiLink Inhalation.
- Semliki_Forest_virus wikiPageWikiLink Lipid.
- Semliki_Forest_virus wikiPageWikiLink Mammal.
- Semliki_Forest_virus wikiPageWikiLink Mosquito.
- Semliki_Forest_virus wikiPageWikiLink Regular_icosahedron.
- Semliki_Forest_virus wikiPageWikiLink Rodent.
- Semliki_Forest_virus wikiPageWikiLink Semuliki_National_Park.
- Semliki_Forest_virus wikiPageWikiLink Sindbis_virus.
- Semliki_Forest_virus wikiPageWikiLink Togaviridae.
- Semliki_Forest_virus wikiPageWikiLink Uganda.
- Semliki_Forest_virus wikiPageWikiLink Uganda_Virus_Research_Institute.
- Semliki_Forest_virus wikiPageWikiLink Vaccine.
- Semliki_Forest_virus wikiPageWikiLink Vector_(molecular_biology).
- Semliki_Forest_virus wikiPageWikiLink File:Emd-1017.jpg.
- Semliki_Forest_virus wikiPageWikiLinkText "Semliki Forest virus".
- Semliki_Forest_virus familia "Togaviridae".
- Semliki_Forest_virus genus "Alphavirus".
- Semliki_Forest_virus hasPhotoCollection Semliki_Forest_virus.
- Semliki_Forest_virus species "Semliki Forest virus".
- Semliki_Forest_virus virusGroup "iv".
- Semliki_Forest_virus wikiPageUsesTemplate Template:Cite_journal.
- Semliki_Forest_virus wikiPageUsesTemplate Template:PDBe.
- Semliki_Forest_virus wikiPageUsesTemplate Template:Reflist.
- Semliki_Forest_virus wikiPageUsesTemplate Template:Taxobox.
- Semliki_Forest_virus wikiPageUsesTemplate Template:Zoonotic_viral_diseases.
- Semliki_Forest_virus subject Category:Alphaviruses.
- Semliki_Forest_virus type Article.
- Semliki_Forest_virus type Species.
- Semliki_Forest_virus type Article.
- Semliki_Forest_virus type Thing.
- Semliki_Forest_virus comment "The Semliki Forest virus was first isolated from mosquitoes in the Semliki Forest, Uganda by the Uganda Virus Research Institute in 1942 and described by Smithburn & Haddow. It is known to cause disease in both animals and humans. It is an Alphavirus found in central, eastern, and southern Africa.The Semliki Forest virus is a positive-stranded RNA virus with a genome of approximately 13,000 base pairs which encodes nine proteins.".
- Semliki_Forest_virus label "Semliki Forest virus".
- Semliki_Forest_virus sameAs Semliki-Forest-Virus.
- Semliki_Forest_virus sameAs Virus_del_bosque_Semliki.
- Semliki_Forest_virus sameAs Semliki_metsa_viirus.
- Semliki_Forest_virus sameAs Virus_de_la_forêt_de_Semliki.
- Semliki_Forest_virus sameAs Semliki_forest_virus.
- Semliki_Forest_virus sameAs m.06hs6y.
- Semliki_Forest_virus sameAs Q428413.
- Semliki_Forest_virus sameAs Q428413.
- Semliki_Forest_virus wasDerivedFrom Semliki_Forest_virus?oldid=678169354.
- Semliki_Forest_virus depiction Semliki-Forest-Virus.jpg.
- Semliki_Forest_virus isPrimaryTopicOf Semliki_Forest_virus.