Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/SR_protein> ?p ?o }
- SR_protein abstract "SR proteins are a conserved family of proteins involved in RNA splicing. SR proteins are named because they contain a protein domain with long repeats of serine and arginine amino acid residues, whose standard abbreviations are "S" and "R" respectively. SR proteins are 50-300 amino acids in length and composed of two domains, the RNA recognition motif (RRM) region and the RS binding domain. SR proteins are more commonly found in the nucleus than the cytoplasm, but several SR proteins are known to shuttle between the nucleus and the cytoplasm.SR proteins were discovered in the 1990s in Drosophila and in amphibian oocytes, and later in humans. In general, metazoans appear to have SR proteins and unicellular organisms lack SR proteins.SR proteins are important in constitutive and alternative pre-mRNA splicing, mRNA export, genome stabilization, nonsense-mediated decay, and translation. SR proteins alternatively splice pre-mRNA by preferentially selecting different splice sites on the pre-mRNA strands to create multiple mRNA transcripts from one pre-mRNA transcript. Once splicing is complete the SR protein may or may not remain attached to help shuttle the mRNA strand out of the nucleus. As RNA Polymerase II is transcribing DNA into RNA, SR proteins attach to newly made pre-mRNA to prevent the pre-mRNA from binding to the coding DNA strand to increase genome stabilization. Topoisomerase I and SR proteins also interact to increase genome stabilization. SR proteins can control the concentrations of specific mRNA that is successfully translated into protein by selecting for nonsense-mediated decay codons during alternative splicing. SR proteins can alternatively splice NMD codons into its own mRNA transcript to auto-regulate the concentration of SR proteins. Through the mTOR pathway and interactions with polyribosomes, SR proteins can increase translation of mRNA.Ataxia telangiectasia, neurofibromatosis type 1, several cancers, HIV-1, and spinal muscular atrophy have all been linked to alternative splicing by SR proteins.".
- SR_protein thumbnail Protein_SFRS9_PDB_1wg4.png?width=300.
- SR_protein wikiPageID "1138554".
- SR_protein wikiPageLength "26474".
- SR_protein wikiPageOutDegree "104".
- SR_protein wikiPageRevisionID "669681776".
- SR_protein wikiPageWikiLink Alternative_splicing.
- SR_protein wikiPageWikiLink Amino_acid.
- SR_protein wikiPageWikiLink Animal.
- SR_protein wikiPageWikiLink Antibody.
- SR_protein wikiPageWikiLink Arginine.
- SR_protein wikiPageWikiLink Ataxia_telangiectasia.
- SR_protein wikiPageWikiLink BRCA1.
- SR_protein wikiPageWikiLink C-terminal.
- SR_protein wikiPageWikiLink C-terminus.
- SR_protein wikiPageWikiLink CDK9.
- SR_protein wikiPageWikiLink Caenorhabditis_elegans.
- SR_protein wikiPageWikiLink Cancer.
- SR_protein wikiPageWikiLink Cancers.
- SR_protein wikiPageWikiLink Category:Biochemistry.
- SR_protein wikiPageWikiLink Category:Molecular_biology.
- SR_protein wikiPageWikiLink Category:Proteins.
- SR_protein wikiPageWikiLink Cell_nucleus.
- SR_protein wikiPageWikiLink Cyclin-dependent_kinase_9.
- SR_protein wikiPageWikiLink Cytosine.
- SR_protein wikiPageWikiLink Cytosol.
- SR_protein wikiPageWikiLink DNA.
- SR_protein wikiPageWikiLink Drosophila.
- SR_protein wikiPageWikiLink EIF4B.
- SR_protein wikiPageWikiLink EIF4E.
- SR_protein wikiPageWikiLink Exon.
- SR_protein wikiPageWikiLink Exon_Junction_Complex.
- SR_protein wikiPageWikiLink Exon_junction_complex.
- SR_protein wikiPageWikiLink Exon_splicing_silencers.
- SR_protein wikiPageWikiLink Exonic_splicing_enhancer.
- SR_protein wikiPageWikiLink Exonic_splicing_enhancers.
- SR_protein wikiPageWikiLink Exonic_splicing_silencer.
- SR_protein wikiPageWikiLink Family_of_proteins.
- SR_protein wikiPageWikiLink File:SR_proteins_competing_with_hnRNPs.png.
- SR_protein wikiPageWikiLink File:SR_proteins_translocation_into_and_out_of_the_nucleus.png.
- SR_protein wikiPageWikiLink HIV.
- SR_protein wikiPageWikiLink HIV-1.
- SR_protein wikiPageWikiLink Heterogeneous_ribonucleoprotein_particle.
- SR_protein wikiPageWikiLink HnRNP.
- SR_protein wikiPageWikiLink Interchromatin_granule_cluster.
- SR_protein wikiPageWikiLink Intron.
- SR_protein wikiPageWikiLink Kinase.
- SR_protein wikiPageWikiLink Kinases.
- SR_protein wikiPageWikiLink Locus_(genetics).
- SR_protein wikiPageWikiLink ERK_pathway.
- SR_protein wikiPageWikiLink MTORC1.
- SR_protein wikiPageWikiLink Metazoans.
- SR_protein wikiPageWikiLink Monoclonal.
- SR_protein wikiPageWikiLink N-terminus.
- SR_protein wikiPageWikiLink NMR.
- SR_protein wikiPageWikiLink NXF1.
- SR_protein wikiPageWikiLink Neurofibromatosis_type_1.
- SR_protein wikiPageWikiLink Neurofibromatosis_type_I.
- SR_protein wikiPageWikiLink Nonsense-mediated_decay.
- SR_protein wikiPageWikiLink Nuclear_magnetic_resonance.
- SR_protein wikiPageWikiLink Nuclear_speckles.
- SR_protein wikiPageWikiLink Oncogene.
- SR_protein wikiPageWikiLink P-TEFb.
- SR_protein wikiPageWikiLink P70-S6_Kinase_1.
- SR_protein wikiPageWikiLink mTOR_pathway.
- SR_protein wikiPageWikiLink Perichromatin_fibril.
- SR_protein wikiPageWikiLink Phenotype.
- SR_protein wikiPageWikiLink Protein_domain.
- SR_protein wikiPageWikiLink Protein_family.
- SR_protein wikiPageWikiLink Proto-oncogene.
- SR_protein wikiPageWikiLink RNA_Polymerase_II.
- SR_protein wikiPageWikiLink RNA_interference.
- SR_protein wikiPageWikiLink RNA_polymerase_II.
- SR_protein wikiPageWikiLink RNA_recognition_motif.
- SR_protein wikiPageWikiLink RNA_splicing.
- SR_protein wikiPageWikiLink RNAi.
- SR_protein wikiPageWikiLink Residue_(chemistry).
- SR_protein wikiPageWikiLink Ribosomal_protein_s6.
- SR_protein wikiPageWikiLink S6K1.
- SR_protein wikiPageWikiLink SC35.
- SR_protein wikiPageWikiLink SFRS3.
- SR_protein wikiPageWikiLink SFRS4.
- SR_protein wikiPageWikiLink SFRS5.
- SR_protein wikiPageWikiLink SFRS6.
- SR_protein wikiPageWikiLink SFRS7.
- SR_protein wikiPageWikiLink SFSWAP.
- SR_protein wikiPageWikiLink SRSF1.
- SR_protein wikiPageWikiLink SRSF10.
- SR_protein wikiPageWikiLink SRSF11.
- SR_protein wikiPageWikiLink SRSF12.
- SR_protein wikiPageWikiLink SRSF2.
- SR_protein wikiPageWikiLink SRSF3.
- SR_protein wikiPageWikiLink SRSF4.
- SR_protein wikiPageWikiLink SRSF5.
- SR_protein wikiPageWikiLink SRSF6.
- SR_protein wikiPageWikiLink SRSF7.
- SR_protein wikiPageWikiLink SRSF8.
- SR_protein wikiPageWikiLink SRSF9.
- SR_protein wikiPageWikiLink Serine.
- SR_protein wikiPageWikiLink arginine-rich_splicing_factor_1.