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- SL-651,498 abstract "SL-651,498 is an anxiolytic and anticonvulsant drug used in scientific research, with a chemical structure most closely related to β-carboline derivatives such as abecarnil and gedocarnil. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.SL-651,498 is a subtype-selective GABAA agonist, which acts as a full agonist at α2 and α3 subtypes, and as a partial agonist at α1 and α5 (although its action at α5 subtypes is much weaker than at the others). In animal studies, it has primarily anxiolytic effects, although some sedation, ataxia and muscle relaxant effects are observed at higher doses. It substitutes fully for the anxiolytic benzodiazepine chlordiazepoxide, but only partially substituted for the imidazopyridine hypnotic drug zolpidem and the benzodiazepine hypnotic triazolam. When given repeatedly it failed to produce tolerance or dependence, probably due to its low affinity and efficacy at the α5 subtype.SL-651,498 has been suggested for development as a novel non-sedating anxiolytic drug for humans, although it is still only at an early stage of research. Preliminary human trials suggest similar efficacy to lorazepam as an anxiolytic, but with little or no sedation or impairment of memory, motor skills or cognitive function.There are other possibly anxioselective compounds in development, such as L-838,417, NGD 91-3.".
- SL-651,498 casNumber "205881-86-3".
- SL-651,498 iupacName "6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyrido[3,4-b]indol-1-one".
- SL-651,498 thumbnail SL-651,498.svg?width=300.
- SL-651,498 wikiPageID "14568994".
- SL-651,498 wikiPageLength "5958".
- SL-651,498 wikiPageOutDegree "33".
- SL-651,498 wikiPageRevisionID "633370300".
- SL-651,498 wikiPageWikiLink Abecarnil.
- SL-651,498 wikiPageWikiLink Agonist.
- SL-651,498 wikiPageWikiLink Anticonvulsant.
- SL-651,498 wikiPageWikiLink Anxiolytic.
- SL-651,498 wikiPageWikiLink Ataxia.
- SL-651,498 wikiPageWikiLink Benzodiazepine.
- SL-651,498 wikiPageWikiLink Beta-Carboline.
- SL-651,498 wikiPageWikiLink Category:Amides.
- SL-651,498 wikiPageWikiLink Category:Anxiolytics.
- SL-651,498 wikiPageWikiLink Category:Beta-Carbolines.
- SL-651,498 wikiPageWikiLink Category:GABAA_receptor_positive_allosteric_modulators.
- SL-651,498 wikiPageWikiLink Category:Lactams.
- SL-651,498 wikiPageWikiLink Category:Organofluorides.
- SL-651,498 wikiPageWikiLink Category:Pyrrolidines.
- SL-651,498 wikiPageWikiLink Chlordiazepoxide.
- SL-651,498 wikiPageWikiLink Full_agonist.
- SL-651,498 wikiPageWikiLink GABAA_receptor.
- SL-651,498 wikiPageWikiLink GABA_A_receptor.
- SL-651,498 wikiPageWikiLink GABRA1.
- SL-651,498 wikiPageWikiLink GABRA2.
- SL-651,498 wikiPageWikiLink GABRA3.
- SL-651,498 wikiPageWikiLink GABRA5.
- SL-651,498 wikiPageWikiLink Gamma-aminobutyric_acid_receptor_subunit_alpha-1.
- SL-651,498 wikiPageWikiLink Gedocarnil.
- SL-651,498 wikiPageWikiLink Hypnotic.
- SL-651,498 wikiPageWikiLink Imidazopyridine.
- SL-651,498 wikiPageWikiLink L-838,417.
- SL-651,498 wikiPageWikiLink Lorazepam.
- SL-651,498 wikiPageWikiLink Muscle_relaxant.
- SL-651,498 wikiPageWikiLink NGD_91-3.
- SL-651,498 wikiPageWikiLink Nonbenzodiazepine.
- SL-651,498 wikiPageWikiLink Partial_agonist.
- SL-651,498 wikiPageWikiLink Sedative.
- SL-651,498 wikiPageWikiLink Triazolam.
- SL-651,498 wikiPageWikiLink Zolpidem.
- SL-651,498 wikiPageWikiLinkText "SL-651,498".
- SL-651,498 c "23".
- SL-651,498 casNumber "205881".
- SL-651,498 chemspiderid "8084030".
- SL-651,498 f "1".
- SL-651,498 h "20".
- SL-651,498 hasPhotoCollection SL-651,498.
- SL-651,498 iupacName "6".
- SL-651,498 molecularWeight "389.421".
- SL-651,498 n "3".
- SL-651,498 o "2".
- SL-651,498 stdinchi "1".
- SL-651,498 stdinchikey "QQWHWWDIFGNCLV-UHFFFAOYSA-N".
- SL-651,498 verifiedfields "changed".
- SL-651,498 verifiedrevid "464385430".
- SL-651,498 wikiPageUsesTemplate Template:Anxiolytics.
- SL-651,498 wikiPageUsesTemplate Template:Drugbox.
- SL-651,498 wikiPageUsesTemplate Template:GABAAR_PAMs.
- SL-651,498 wikiPageUsesTemplate Template:Reflist.
- SL-651,498 subject Category:Amides.
- SL-651,498 subject Category:Anxiolytics.
- SL-651,498 subject Category:Beta-Carbolines.
- SL-651,498 subject Category:GABAA_receptor_positive_allosteric_modulators.
- SL-651,498 subject Category:Lactams.
- SL-651,498 subject Category:Organofluorides.
- SL-651,498 subject Category:Pyrrolidines.
- SL-651,498 hypernym Drug.
- SL-651,498 type ChemicalSubstance.
- SL-651,498 type Drug.
- SL-651,498 type ChemicalObject.
- SL-651,498 type Thing.
- SL-651,498 type Q8386.
- SL-651,498 comment "SL-651,498 is an anxiolytic and anticonvulsant drug used in scientific research, with a chemical structure most closely related to β-carboline derivatives such as abecarnil and gedocarnil.".
- SL-651,498 label "SL-651,498".
- SL-651,498 sameAs m.03d85hj.
- SL-651,498 sameAs SL-651,498.
- SL-651,498 sameAs SL-651,498.
- SL-651,498 sameAs Q7390716.
- SL-651,498 sameAs Q7390716.
- SL-651,498 wasDerivedFrom SL-651,498?oldid=633370300.
- SL-651,498 depiction SL-651,498.svg.
- SL-651,498 isPrimaryTopicOf SL-651,498.