Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/SKAP1> ?p ?o }
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- SKAP1 abstract "Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.This gene encodes a T cell adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adapter protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.The demonstration that SKAP1 regulates LFA-1 adhesion was made by retroviral infection and by the SKAP1 deficient mouse. Additional work has implicated SKAP1 in binding to the exchange factor RasGRP1 and in regulating ERK activation in T-cells.".
- SKAP1 entrezgene "8631".
- SKAP1 wikiPageID "14819484".
- SKAP1 wikiPageLength "10875".
- SKAP1 wikiPageOutDegree "22".
- SKAP1 wikiPageRevisionID "679039489".
- SKAP1 wikiPageWikiLink Adapter_protein.
- SKAP1 wikiPageWikiLink Adhesion_and_degranulation-promoting.
- SKAP1 wikiPageWikiLink Antigen.
- SKAP1 wikiPageWikiLink C-terminal.
- SKAP1 wikiPageWikiLink C-terminus.
- SKAP1 wikiPageWikiLink Extracellular_signal-regulated_kinases.
- SKAP1 wikiPageWikiLink FYB.
- SKAP1 wikiPageWikiLink FYN.
- SKAP1 wikiPageWikiLink Gene.
- SKAP1 wikiPageWikiLink Guanine_nucleotide_exchange_factor.
- SKAP1 wikiPageWikiLink Inside-out_signaling.
- SKAP1 wikiPageWikiLink Integrin.
- SKAP1 wikiPageWikiLink Integrins.
- SKAP1 wikiPageWikiLink LFA-1.
- SKAP1 wikiPageWikiLink Lymphocyte_function-associated_antigen_1.
- SKAP1 wikiPageWikiLink N-terminal.
- SKAP1 wikiPageWikiLink N-terminus.
- SKAP1 wikiPageWikiLink PH_domain.
- SKAP1 wikiPageWikiLink PTPRC.
- SKAP1 wikiPageWikiLink Pleckstrin_homology_domain.
- SKAP1 wikiPageWikiLink Protein-protein_interaction.
- SKAP1 wikiPageWikiLink Protein–protein_interaction.
- SKAP1 wikiPageWikiLink RASGRP1.
- SKAP1 wikiPageWikiLink Receptor_stimulation.
- SKAP1 wikiPageWikiLink SH3_domain.
- SKAP1 wikiPageWikiLink Signal_transducing_adaptor_protein.
- SKAP1 wikiPageWikiLink T_cell.
- SKAP1 wikiPageWikiLinkText "SKAP1".
- SKAP1 hasPhotoCollection SKAP1.
- SKAP1 requireManualInspection "no".
- SKAP1 summaryText "This gene encodes a T cell adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adapter protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.".
- SKAP1 updateCitations "yes".
- SKAP1 updatePage "yes".
- SKAP1 updateProteinBox "yes".
- SKAP1 updateSummary "yes".
- SKAP1 wikiPageUsesTemplate Template:Gene-17-stub.
- SKAP1 wikiPageUsesTemplate Template:PBB.
- SKAP1 wikiPageUsesTemplate Template:PBB_Controls.
- SKAP1 wikiPageUsesTemplate Template:PBB_Further_reading.
- SKAP1 wikiPageUsesTemplate Template:PBB_Summary.
- SKAP1 wikiPageUsesTemplate Template:PDB_Gallery.
- SKAP1 wikiPageUsesTemplate Template:Refbegin.
- SKAP1 wikiPageUsesTemplate Template:Refend.
- SKAP1 wikiPageUsesTemplate Template:Reflist.
- SKAP1 hypernym Protein.
- SKAP1 type Biomolecule.
- SKAP1 type Protein.
- SKAP1 type Thing.
- SKAP1 type Q206229.
- SKAP1 type Q8054.
- SKAP1 comment "Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.This gene encodes a T cell adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain.".
- SKAP1 label "SKAP1".
- SKAP1 sameAs m.03gz1sd.
- SKAP1 sameAs Q7390584.
- SKAP1 sameAs Q7390584.
- SKAP1 wasDerivedFrom SKAP1?oldid=679039489.
- SKAP1 isPrimaryTopicOf SKAP1.