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- SB-277,011-A abstract "SB-277,011A is a drug which acts as a potent and selective dopamine D3 receptor antagonist, which is around 80-100x selective for D3 over D2, and lacks any partial agonist activity.SB-277,011A is used in the study of addiction to stimulant drugs such as nicotine and cocaine. Where cocaine reduces the threshold for brain electrical self-stimulation in rats, an indication of cocaine's rewarding effects, SB-277,011A completely reverses this effect. It may thus be useful in the treatment of addiction to nicotine and cocaine, and is also being investigated for potential uses in the treatment of other drug addictions, such as addiction to heroin and alcohol.Another potential application for SB-277,011A is in the treatment of schizophrenia, and it may be particularly useful in treating comorbid patients who are both schizophrenic and addicted to drugs. However it may worsen side effects such as tardive dyskinesia in patients who are already prescribed antipsychotic drugs.".
- SB-277,011-A iupacName "N-{trans-4-[2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]cyclohexyl}quinoline-4-carboxamide".
- SB-277,011-A pubchem "5311096".
- SB-277,011-A thumbnail SB2770112DACS.svg?width=300.
- SB-277,011-A wikiPageID "14095223".
- SB-277,011-A wikiPageLength "10938".
- SB-277,011-A wikiPageOutDegree "20".
- SB-277,011-A wikiPageRevisionID "640799872".
- SB-277,011-A wikiPageWikiLink Alcoholic_beverage.
- SB-277,011-A wikiPageWikiLink Antipsychotic.
- SB-277,011-A wikiPageWikiLink Category:Amides.
- SB-277,011-A wikiPageWikiLink Category:D3_antagonists.
- SB-277,011-A wikiPageWikiLink Category:Nitriles.
- SB-277,011-A wikiPageWikiLink Category:Quinolines.
- SB-277,011-A wikiPageWikiLink Category:Tetrahydroisoquinolines.
- SB-277,011-A wikiPageWikiLink Cocaine.
- SB-277,011-A wikiPageWikiLink Comorbid.
- SB-277,011-A wikiPageWikiLink Comorbidity.
- SB-277,011-A wikiPageWikiLink Dopamine.
- SB-277,011-A wikiPageWikiLink Dopamine_receptor_D3.
- SB-277,011-A wikiPageWikiLink Heroin.
- SB-277,011-A wikiPageWikiLink Nicotine.
- SB-277,011-A wikiPageWikiLink Partial_agonist.
- SB-277,011-A wikiPageWikiLink Receptor_antagonist.
- SB-277,011-A wikiPageWikiLink Reward_system.
- SB-277,011-A wikiPageWikiLink Schizophrenia.
- SB-277,011-A wikiPageWikiLink Stimulant.
- SB-277,011-A wikiPageWikiLink Substance_dependence.
- SB-277,011-A wikiPageWikiLink Tardive_dyskinesia.
- SB-277,011-A wikiPageWikiLinkText "SB-277,011-A".
- SB-277,011-A wikiPageWikiLinkText "SB-277011-A".
- SB-277,011-A c "28".
- SB-277,011-A chembl "85606".
- SB-277,011-A h "30".
- SB-277,011-A hasPhotoCollection SB-277,011-A.
- SB-277,011-A iupacName "N-{trans-4-[2-ethyl]cyclohexyl}quinoline-4-carboxamide".
- SB-277,011-A iupharLigand "143".
- SB-277,011-A molecularWeight "438.563".
- SB-277,011-A n "4".
- SB-277,011-A o "1".
- SB-277,011-A pubchem "5311096".
- SB-277,011-A smiles "c4cccc1c4nccc1CNC3CCCCCNCc2ccc5C#N".
- SB-277,011-A verifiedfields "changed".
- SB-277,011-A verifiedrevid "449588534".
- SB-277,011-A width "300".
- SB-277,011-A wikiPageUsesTemplate Template:Dopaminergics.
- SB-277,011-A wikiPageUsesTemplate Template:Drugbox.
- SB-277,011-A wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- SB-277,011-A wikiPageUsesTemplate Template:Reflist.
- SB-277,011-A subject Category:Amides.
- SB-277,011-A subject Category:D3_antagonists.
- SB-277,011-A subject Category:Nitriles.
- SB-277,011-A subject Category:Quinolines.
- SB-277,011-A subject Category:Tetrahydroisoquinolines.
- SB-277,011-A hypernym Drug.
- SB-277,011-A type ChemicalSubstance.
- SB-277,011-A type Drug.
- SB-277,011-A type ChemicalObject.
- SB-277,011-A type Thing.
- SB-277,011-A type Q8386.
- SB-277,011-A comment "SB-277,011A is a drug which acts as a potent and selective dopamine D3 receptor antagonist, which is around 80-100x selective for D3 over D2, and lacks any partial agonist activity.SB-277,011A is used in the study of addiction to stimulant drugs such as nicotine and cocaine. Where cocaine reduces the threshold for brain electrical self-stimulation in rats, an indication of cocaine's rewarding effects, SB-277,011A completely reverses this effect.".
- SB-277,011-A label "SB-277,011-A".
- SB-277,011-A sameAs SB-277011-A.
- SB-277,011-A sameAs m.03ctfqf.
- SB-277,011-A sameAs SB-277011-A.
- SB-277,011-A sameAs SB-277011-A.
- SB-277,011-A sameAs Q7388910.
- SB-277,011-A sameAs Q7388910.
- SB-277,011-A wasDerivedFrom SB-277,011-A?oldid=640799872.
- SB-277,011-A depiction SB2770112DACS.svg.
- SB-277,011-A isPrimaryTopicOf SB-277,011-A.