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- SB-269970 abstract "SB-269970 is a drug and research chemical developed by GlaxoSmithKline used in scientific studies. It was previously believed to act as a selective 5-HT7 receptor antagonist (or possibly inverse agonist), but a subsequent discovery showed that it also potently blocks the α2-adrenergic receptor. The new finding has raised significant concerns about studies using SB-269970 as a specific serotonin receptor antagonist.SB-269970 is used to study the 5-HT7 receptors which are thought to be involved in the function of several areas of the brain such as the hippocampus and thalamus, and regulation of dopamine release in the ventral tegmental area. Possible therapeutic uses for SB-269970 and other 5-HT7 antagonists include the treatment of anxiety and depression, and nootropic effects have also been noted in animal studies.".
- SB-269970 casNumber "201038-74-6".
- SB-269970 iupacName "(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2 -(2-(4-methyl-1-piperidinyl)ethyl)pyrrolidine".
- SB-269970 pubchem "6604889".
- SB-269970 thumbnail SB-269,970_structure.png?width=300.
- SB-269970 wikiPageID "21489647".
- SB-269970 wikiPageLength "5778".
- SB-269970 wikiPageOutDegree "19".
- SB-269970 wikiPageRevisionID "679038004".
- SB-269970 wikiPageWikiLink 5-HT7.
- SB-269970 wikiPageWikiLink 5-HT7_receptor.
- SB-269970 wikiPageWikiLink Alpha-2_adrenergic_receptor.
- SB-269970 wikiPageWikiLink Antagonist_(pharmacology).
- SB-269970 wikiPageWikiLink Anxiety.
- SB-269970 wikiPageWikiLink Category:5-HT7_antagonists.
- SB-269970 wikiPageWikiLink Category:Alpha_blockers.
- SB-269970 wikiPageWikiLink Category:Phenols.
- SB-269970 wikiPageWikiLink Category:Piperidines.
- SB-269970 wikiPageWikiLink Category:Pyrrolidines.
- SB-269970 wikiPageWikiLink Clinical_depression.
- SB-269970 wikiPageWikiLink Drug.
- SB-269970 wikiPageWikiLink GlaxoSmithKline.
- SB-269970 wikiPageWikiLink Hippocampus.
- SB-269970 wikiPageWikiLink Inverse_agonist.
- SB-269970 wikiPageWikiLink Major_depressive_disorder.
- SB-269970 wikiPageWikiLink Nootropic.
- SB-269970 wikiPageWikiLink Receptor_(biochemistry).
- SB-269970 wikiPageWikiLink Receptor_antagonist.
- SB-269970 wikiPageWikiLink Serotonin.
- SB-269970 wikiPageWikiLink Thalamus.
- SB-269970 wikiPageWikiLink Ventral_tegmental_area.
- SB-269970 wikiPageWikiLinkText "SB-269970".
- SB-269970 c "18".
- SB-269970 casNumber "201038".
- SB-269970 chembl "282199".
- SB-269970 h "28".
- SB-269970 hasPhotoCollection SB-269970.
- SB-269970 iupacName "-1".
- SB-269970 iupharLigand "3233".
- SB-269970 molecularWeight "352.49".
- SB-269970 n "2".
- SB-269970 o "3".
- SB-269970 pubchem "6604889".
- SB-269970 s "1".
- SB-269970 smiles "CC2CCNCCC1CCCN1Sccccc3O".
- SB-269970 verifiedfields "changed".
- SB-269970 verifiedrevid "407721350".
- SB-269970 width "220".
- SB-269970 wikiPageUsesTemplate Template:Adrenergics.
- SB-269970 wikiPageUsesTemplate Template:Antihypertensive-stub.
- SB-269970 wikiPageUsesTemplate Template:Drugbox.
- SB-269970 wikiPageUsesTemplate Template:Reflist.
- SB-269970 wikiPageUsesTemplate Template:Serotonergics.
- SB-269970 subject Category:5-HT7_antagonists.
- SB-269970 subject Category:Alpha_blockers.
- SB-269970 subject Category:Phenols.
- SB-269970 subject Category:Piperidines.
- SB-269970 subject Category:Pyrrolidines.
- SB-269970 hypernym Drug.
- SB-269970 type ChemicalSubstance.
- SB-269970 type Drug.
- SB-269970 type ChemicalObject.
- SB-269970 type Thing.
- SB-269970 type Q8386.
- SB-269970 comment "SB-269970 is a drug and research chemical developed by GlaxoSmithKline used in scientific studies. It was previously believed to act as a selective 5-HT7 receptor antagonist (or possibly inverse agonist), but a subsequent discovery showed that it also potently blocks the α2-adrenergic receptor.".
- SB-269970 label "SB-269970".
- SB-269970 sameAs m.05h3f5h.
- SB-269970 sameAs SB-269,970.
- SB-269970 sameAs SB-269,970.
- SB-269970 sameAs Q1427742.
- SB-269970 sameAs Q1427742.
- SB-269970 wasDerivedFrom SB-269970?oldid=679038004.
- SB-269970 depiction SB-269,970_structure.png.
- SB-269970 isPrimaryTopicOf SB-269970.