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- Recombinase-mediated_cassette_exchange abstract "In the field of reverse genetics RMCE (recombinase-mediated cassette exchange) is of increasing relevance. Based on the features of site-specific recombination processes (SSRs), the procedure permits the systematic, repeated modification of higher eukaryotic genomes by targeted integration. For RMCE, this is achieved by the clean exchange of a preexisting gene cassette for an analogous cassette carrying the "gene of interest" (GOI).The genetic modification of mammalian cells is a standard procedure for the production of correctly modified proteins with pharmaceutical relevance. To be successful, the transfer and expression of the transgene has to be highly efficient and should have a largely predictable outcome. Current developments in the field of gene therapy are based on the same principles. Traditional procedures used for transfer of GOIs are not sufficiently reliable, mostly because the relevant epigenetic influences have not been sufficiently explored: transgenes integrate into chromosomes with low efficiency and at loci that provide only sub-optimal conditions for their expression. As a consequence the newly introduced information may not be realized (expressed), the gene(s) may be lost and/or re-insert and they may render the target cells in unstable state. It is exactly this point where RMCE enters the field. The procedure was introduced in 1994 and it uses the tools yeasts and bacteriophages have evolved for the efficient replication of important genetic information:".
- Recombinase-mediated_cassette_exchange thumbnail RMCE2.PNG?width=300.
- Recombinase-mediated_cassette_exchange wikiPageExternalLink 111130115822.htm.
- Recombinase-mediated_cassette_exchange wikiPageID "14032539".
- Recombinase-mediated_cassette_exchange wikiPageLength "17897".
- Recombinase-mediated_cassette_exchange wikiPageOutDegree "34".
- Recombinase-mediated_cassette_exchange wikiPageRevisionID "673320464".
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Bacteriophage.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Bacteriophages.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Category:Applied_genetics.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Category:Genetics.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Category:Molecular_genetics.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Chromosomal_crossover.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Chromosomal_inversion.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Cre-Lox_recombination.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Cre_recombinase.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Deletion_(genetics).
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Enhancer_(genetics).
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Epigenetics.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink FLP-FRT_recombination.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink File:RMCE2.PNG.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Gene_cassette.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Gene_expression.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Gene_therapy.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Genetic_recombination.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Homologous_recombination.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Insulator_(genetics).
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Monomer.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Monomers.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Reverse_genetics.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Site-specific_recombinase_technology.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Site-specific_recombination.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Stem_cell.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Stem_cells.
- Recombinase-mediated_cassette_exchange wikiPageWikiLink Transgene.
- Recombinase-mediated_cassette_exchange wikiPageWikiLinkText "(RMCE)".
- Recombinase-mediated_cassette_exchange wikiPageWikiLinkText "Flp-RMCE".
- Recombinase-mediated_cassette_exchange wikiPageWikiLinkText "RMCE".
- Recombinase-mediated_cassette_exchange wikiPageWikiLinkText "Recombinase-mediated cassette exchange".
- Recombinase-mediated_cassette_exchange wikiPageWikiLinkText "multiplexing-RMCE".
- Recombinase-mediated_cassette_exchange wikiPageWikiLinkText "recombinase-mediated cassette exchange".
- Recombinase-mediated_cassette_exchange hasPhotoCollection Recombinase-mediated_cassette_exchange.
- Recombinase-mediated_cassette_exchange wikiPageUsesTemplate Template:Cite_journal.
- Recombinase-mediated_cassette_exchange wikiPageUsesTemplate Template:Em.
- Recombinase-mediated_cassette_exchange wikiPageUsesTemplate Template:Reflist.
- Recombinase-mediated_cassette_exchange subject Category:Applied_genetics.
- Recombinase-mediated_cassette_exchange subject Category:Genetics.
- Recombinase-mediated_cassette_exchange subject Category:Molecular_genetics.
- Recombinase-mediated_cassette_exchange type Science.
- Recombinase-mediated_cassette_exchange comment "In the field of reverse genetics RMCE (recombinase-mediated cassette exchange) is of increasing relevance. Based on the features of site-specific recombination processes (SSRs), the procedure permits the systematic, repeated modification of higher eukaryotic genomes by targeted integration.".
- Recombinase-mediated_cassette_exchange label "Recombinase-mediated cassette exchange".
- Recombinase-mediated_cassette_exchange sameAs RMCE-Kassettenaustauschverfahren.
- Recombinase-mediated_cassette_exchange sameAs Intercambio_de_Cassette_Recombinasa_Mediada.
- Recombinase-mediated_cassette_exchange sameAs m.03crlk8.
- Recombinase-mediated_cassette_exchange sameAs Q2124342.
- Recombinase-mediated_cassette_exchange sameAs Q2124342.
- Recombinase-mediated_cassette_exchange wasDerivedFrom Recombinase-mediated_cassette_exchange?oldid=673320464.
- Recombinase-mediated_cassette_exchange depiction RMCE2.PNG.
- Recombinase-mediated_cassette_exchange isPrimaryTopicOf Recombinase-mediated_cassette_exchange.