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- RWJ-394674 abstract "RWJ-394674 is a drug that is used in scientific research. It is a potent, orally active analgesic drug that produces little respiratory depression. RWJ-394674 itself is a potent and selective agonist for δ-opioid receptors, with a Ki of 0.24 nM at δ and 72 nM at μ. However once inside the body, RWJ-394674 is dealkylated to its monodesethyl metabolite RWJ-413216, which is a potent agonist at the μ-opioid receptor and has less affinity for δ (Ki 0.26 nM at μ, 46.7 nM at δ). The effect of RWJ-394674 when administered in vivo thus produces potent agonist effects at both μ and δ receptors through the combined actions of the parent drug and its active metabolite, with the δ-agonist effects counteracting the respiratory depression from the μ-opioid effects, and the only prominent side-effect being sedation.".
- RWJ-394674 iupacName "N,N-diethyl-4-((8-phenethyl-8-azabicyclo[3.2.1]oct-3-ylidene)phenylmethyl)benzamide".
- RWJ-394674 pubchem "10205965".
- RWJ-394674 thumbnail RWJ-394,674.png?width=300.
- RWJ-394674 wikiPageID "17320820".
- RWJ-394674 wikiPageLength "1975".
- RWJ-394674 wikiPageOutDegree "14".
- RWJ-394674 wikiPageRevisionID "618387828".
- RWJ-394674 wikiPageWikiLink Agonist.
- RWJ-394674 wikiPageWikiLink Analgesic.
- RWJ-394674 wikiPageWikiLink Category:Benzamides.
- RWJ-394674 wikiPageWikiLink Category:Delta-opioid_agonists.
- RWJ-394674 wikiPageWikiLink Category:Mu-opioid_agonists.
- RWJ-394674 wikiPageWikiLink Category:Opioids.
- RWJ-394674 wikiPageWikiLink Category:Tropanes.
- RWJ-394674 wikiPageWikiLink Delta_opioid_receptor.
- RWJ-394674 wikiPageWikiLink Dissociation_constant.
- RWJ-394674 wikiPageWikiLink Hypoventilation.
- RWJ-394674 wikiPageWikiLink Mu_opioid_receptor.
- RWJ-394674 wikiPageWikiLink RWJ-413216.
- RWJ-394674 wikiPageWikiLink Receptor_(biochemistry).
- RWJ-394674 wikiPageWikiLink Respiratory_depression.
- RWJ-394674 wikiPageWikiLink Sedation.
- RWJ-394674 wikiPageWikiLink Δ-opioid_receptor.
- RWJ-394674 wikiPageWikiLink Μ-opioid_receptor.
- RWJ-394674 wikiPageWikiLinkText "RWJ-394674".
- RWJ-394674 c "33".
- RWJ-394674 h "38".
- RWJ-394674 hasPhotoCollection RWJ-394674.
- RWJ-394674 iupacName "N,N-diethyl-4-benzamide".
- RWJ-394674 legalStatus "Legal".
- RWJ-394674 molecularWeight "478.667".
- RWJ-394674 n "2".
- RWJ-394674 o "1".
- RWJ-394674 pubchem "10205965".
- RWJ-394674 smiles "c5ccccc5CCN1CCCC1CC4=Cc2ccccc2".
- RWJ-394674 verifiedrevid "448097844".
- RWJ-394674 width "260".
- RWJ-394674 wikiPageUsesTemplate Template:Analgesic-stub.
- RWJ-394674 wikiPageUsesTemplate Template:Drugbox.
- RWJ-394674 wikiPageUsesTemplate Template:Opioidergics.
- RWJ-394674 wikiPageUsesTemplate Template:Reflist.
- RWJ-394674 subject Category:Benzamides.
- RWJ-394674 subject Category:Delta-opioid_agonists.
- RWJ-394674 subject Category:Mu-opioid_agonists.
- RWJ-394674 subject Category:Opioids.
- RWJ-394674 subject Category:Tropanes.
- RWJ-394674 hypernym Drug.
- RWJ-394674 type Article.
- RWJ-394674 type ChemicalSubstance.
- RWJ-394674 type Drug.
- RWJ-394674 type Agonist.
- RWJ-394674 type Alkaloid.
- RWJ-394674 type Analgesic.
- RWJ-394674 type Article.
- RWJ-394674 type Carboxamide.
- RWJ-394674 type Chemical.
- RWJ-394674 type Drug.
- RWJ-394674 type Heterocycle.
- RWJ-394674 type Opioid.
- RWJ-394674 type ChemicalObject.
- RWJ-394674 type Thing.
- RWJ-394674 type Q8386.
- RWJ-394674 comment "RWJ-394674 is a drug that is used in scientific research. It is a potent, orally active analgesic drug that produces little respiratory depression. RWJ-394674 itself is a potent and selective agonist for δ-opioid receptors, with a Ki of 0.24 nM at δ and 72 nM at μ. However once inside the body, RWJ-394674 is dealkylated to its monodesethyl metabolite RWJ-413216, which is a potent agonist at the μ-opioid receptor and has less affinity for δ (Ki 0.26 nM at μ, 46.7 nM at δ).".
- RWJ-394674 label "RWJ-394674".
- RWJ-394674 sameAs m.043knly.
- RWJ-394674 sameAs RWJ-394,674.
- RWJ-394674 sameAs RWJ-394,674.
- RWJ-394674 sameAs Q7278114.
- RWJ-394674 sameAs Q7278114.
- RWJ-394674 wasDerivedFrom RWJ-394674?oldid=618387828.
- RWJ-394674 depiction RWJ-394,674.png.
- RWJ-394674 isPrimaryTopicOf RWJ-394674.