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- REV3L abstract "Protein reversionless 3-like (REV3L) also known as DNA polymerase zeta catalytic subunit (POLZ) is an enzyme that in humans is encoded by the REV3L gene.The Rev3 subunit interacts with Rev7 to form Pol ζ, a B family polymerase. Pol ζ lacks 3' to 5' exonuclease activity and is a moderate fidelity polymerase. It cannot add nucleotides across from DNA lesions, yet it can extend from primers with terminal mismatches. This makes Pol ζ very important in translesion synthesis (TLS), because it can act in concert with other TLS polymerases that can add across the lesion to complete the bypass of the lesion. Most polymerases have difficulty extending mismatches because they cannot bind properly to the mismatched DNA. So rather than the cell dying, it can survive albeit with a mutation that may or may not be deleterious, so it is believed that Pol ζ is a driving force of evolution.".
- REV3L entrezgene "5980".
- REV3L wikiPageID "14875307".
- REV3L wikiPageLength "8871".
- REV3L wikiPageOutDegree "8".
- REV3L wikiPageRevisionID "673319704".
- REV3L wikiPageWikiLink DNA_polymerase.
- REV3L wikiPageWikiLink DNA_repair.
- REV3L wikiPageWikiLink Enzyme.
- REV3L wikiPageWikiLink Exonuclease.
- REV3L wikiPageWikiLink Fidelity.
- REV3L wikiPageWikiLink Gene.
- REV3L wikiPageWikiLink MAD2L2.
- REV3L wikiPageWikiLink Protein-protein_interaction.
- REV3L wikiPageWikiLink Protein–protein_interaction.
- REV3L wikiPageWikiLink Translesion_synthesis.
- REV3L wikiPageWikiLinkText "REV3L".
- REV3L wikiPageWikiLinkText "Rev3".
- REV3L hasPhotoCollection REV3L.
- REV3L wikiPageUsesTemplate Template:Citation_needed.
- REV3L wikiPageUsesTemplate Template:Cite_journal.
- REV3L wikiPageUsesTemplate Template:Gene-6-stub.
- REV3L wikiPageUsesTemplate Template:PBB.
- REV3L wikiPageUsesTemplate Template:Refbegin.
- REV3L wikiPageUsesTemplate Template:Refend.
- REV3L wikiPageUsesTemplate Template:Reflist.
- REV3L hypernym Enzyme.
- REV3L type Article.
- REV3L type Biomolecule.
- REV3L type Protein.
- REV3L type Article.
- REV3L type Thing.
- REV3L type Q206229.
- REV3L type Q8054.
- REV3L comment "Protein reversionless 3-like (REV3L) also known as DNA polymerase zeta catalytic subunit (POLZ) is an enzyme that in humans is encoded by the REV3L gene.The Rev3 subunit interacts with Rev7 to form Pol ζ, a B family polymerase. Pol ζ lacks 3' to 5' exonuclease activity and is a moderate fidelity polymerase. It cannot add nucleotides across from DNA lesions, yet it can extend from primers with terminal mismatches.".
- REV3L label "REV3L".
- REV3L sameAs m.03g_vp3.
- REV3L sameAs Q7276400.
- REV3L sameAs Q7276400.
- REV3L wasDerivedFrom REV3L?oldid=673319704.
- REV3L isPrimaryTopicOf REV3L.