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- QH-II-66 abstract "QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more selective than most other drugs of this class and so produces somewhat less sedation and ataxia than other related drugs such as diazepam and triazolam, although it still retains anticonvulsant effects.QH-ii-066 is a highly subtype-selective GABAA agonist which was designed to bind selectively to the α5 subtype of GABAA receptors.The α5 subtype (and to a lesser extent the α1 subtype) of GABAA are two of the most important targets in the brain that produce the effects of alcohol, and so one of the purposes for which QH-ii-066 was developed was to reproduce the GABAergic effects of alcohol separately from its other actions.QH-ii-066 replicates some of the effects of alcohol, such as sedation and ataxia, but does not increase appetite, as this effect seems to be produced by the α1 subtype of GABAA rather than α5. It is also interesting to note that the inverse agonist Ro15-4513, which blocks the α4 subtype of GABAA, reverses the effects of alcohol, suggesting that this subtype is also important in producing the subjective effects of alcohol intoxication.".
- QH-II-66 casNumber "183239-39-6".
- QH-II-66 iupacName "7-ethynyl-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one".
- QH-II-66 pubchem "9838431".
- QH-II-66 thumbnail QH-II-66-2D-skeletal.svg?width=300.
- QH-II-66 wikiPageID "13353724".
- QH-II-66 wikiPageLength "5813".
- QH-II-66 wikiPageOutDegree "20".
- QH-II-66 wikiPageRevisionID "633359447".
- QH-II-66 wikiPageWikiLink Agonist.
- QH-II-66 wikiPageWikiLink Alcoholic_beverage.
- QH-II-66 wikiPageWikiLink Anticonvulsant.
- QH-II-66 wikiPageWikiLink Ataxia.
- QH-II-66 wikiPageWikiLink Benzodiazepine.
- QH-II-66 wikiPageWikiLink Category:Alkynes.
- QH-II-66 wikiPageWikiLink Category:Benzodiazepines.
- QH-II-66 wikiPageWikiLink Category:GABAA_receptor_positive_allosteric_modulators.
- QH-II-66 wikiPageWikiLink Category:Hypnotics.
- QH-II-66 wikiPageWikiLink Category:Lactams.
- QH-II-66 wikiPageWikiLink Category:Sedatives.
- QH-II-66 wikiPageWikiLink Diazepam.
- QH-II-66 wikiPageWikiLink GABAA_receptor.
- QH-II-66 wikiPageWikiLink GABRA5.
- QH-II-66 wikiPageWikiLink Gamma-Aminobutyric_acid.
- QH-II-66 wikiPageWikiLink Gamma-aminobutyric_acid.
- QH-II-66 wikiPageWikiLink Inverse_agonist.
- QH-II-66 wikiPageWikiLink Ro15-4513.
- QH-II-66 wikiPageWikiLink SH-053-R-CH3-2′F.
- QH-II-66 wikiPageWikiLink Sedative.
- QH-II-66 wikiPageWikiLink Triazolam.
- QH-II-66 wikiPageWikiLinkText "QH-II-66".
- QH-II-66 wikiPageWikiLinkText "QH-ii-066".
- QH-II-66 c "18".
- QH-II-66 casNumber "183239".
- QH-II-66 chembl "174535".
- QH-II-66 chemspiderid "8014151".
- QH-II-66 h "14".
- QH-II-66 hasPhotoCollection QH-II-66.
- QH-II-66 image "Qhii663d.png".
- QH-II-66 inchi "1".
- QH-II-66 inchikey "FESCSZDQOFYRDR-UHFFFAOYAE".
- QH-II-66 iupacName "7".
- QH-II-66 molecularWeight "274.33".
- QH-II-66 n "2".
- QH-II-66 o "1".
- QH-II-66 pubchem "9838431".
- QH-II-66 smiles "O=C1NC2=CC=CC#C".
- QH-II-66 stdinchi "1".
- QH-II-66 stdinchikey "FESCSZDQOFYRDR-UHFFFAOYSA-N".
- QH-II-66 verifiedfields "changed".
- QH-II-66 verifiedrevid "464378091".
- QH-II-66 watchedfields "changed".
- QH-II-66 width "150".
- QH-II-66 wikiPageUsesTemplate Template:Benzodiazepines.
- QH-II-66 wikiPageUsesTemplate Template:Drugbox.
- QH-II-66 wikiPageUsesTemplate Template:GABAAR_PAMs.
- QH-II-66 wikiPageUsesTemplate Template:Hypnotics_and_sedatives.
- QH-II-66 wikiPageUsesTemplate Template:Reflist.
- QH-II-66 wikiPageUsesTemplate Template:Sedative-stub.
- QH-II-66 subject Category:Alkynes.
- QH-II-66 subject Category:Benzodiazepines.
- QH-II-66 subject Category:GABAA_receptor_positive_allosteric_modulators.
- QH-II-66 subject Category:Hypnotics.
- QH-II-66 subject Category:Lactams.
- QH-II-66 subject Category:Sedatives.
- QH-II-66 hypernym Drug.
- QH-II-66 type Article.
- QH-II-66 type ChemicalSubstance.
- QH-II-66 type Drug.
- QH-II-66 type Alkyne.
- QH-II-66 type Amide.
- QH-II-66 type Anticonvulsant.
- QH-II-66 type Article.
- QH-II-66 type Benzodiazepine.
- QH-II-66 type Drug.
- QH-II-66 type Heterocycle.
- QH-II-66 type Hydrocarbon.
- QH-II-66 type Lactam.
- QH-II-66 type ChemicalObject.
- QH-II-66 type Thing.
- QH-II-66 type Q8386.
- QH-II-66 comment "QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative.".
- QH-II-66 label "QH-II-66".
- QH-II-66 sameAs m.03c2mrp.
- QH-II-66 sameAs QH-II-66.
- QH-II-66 sameAs QH-II-66.
- QH-II-66 sameAs Q7265454.
- QH-II-66 sameAs Q7265454.
- QH-II-66 wasDerivedFrom QH-II-66?oldid=633359447.
- QH-II-66 depiction QH-II-66-2D-skeletal.svg.
- QH-II-66 isPrimaryTopicOf QH-II-66.