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- Polyketide_synthesis_cyclase_family abstract "In molecular biology, the polyketide synthesis cyclase family of proteins includes a number of cyclases involved in polyketide synthesis in a number of actinobacterial species.Aromatic polyketides are assembled by a type II (iterative) polyketide synthase in bacteria. Iterative type II polyketide synthases produce polyketide chains of variable but defined length from a specific starter unit and a number of extender units. They also specify the initial regiospecific folding and cyclisation pattern of nascent polyketides either through the action of a cyclase (CYC) subunit or through the combined action of site-specific ketoreductase and CYC subunits. Additional CYCs and other modifications may be necessary to produce linear aromatic polyketides. The Tetracenomycin polyketide synthesis protein, tcmI, from Streptomyces glaucescens catalyses an aromatic rearrangement in the biosynthetic pathaway of tetracenomycin C from Streptomyces coelicolor. The protein is a homodimer where each subunit forms a beta-alpha-beta fold belonging to the ferrodoxin fold superfamily. Four strands of antiparallel sheets and a layer of alpha helices create a cavity which was proposed to be the active site. This structure shows strong topological similarity to a polyketide monoxygenase from Streptomyces coelicolor which functions in the actinorhodin biosynthesic pathway. It was suggested, therefore, that this fold is well suited to serve as a framework for rearrangements and chemical modification of polyaromatic substrates.".
- Polyketide_synthesis_cyclase_family symbol "Cyclase_polyket".
- Polyketide_synthesis_cyclase_family thumbnail PDB_1tuw_EBI.jpg?width=300.
- Polyketide_synthesis_cyclase_family wikiPageID "32560937".
- Polyketide_synthesis_cyclase_family wikiPageLength "3114".
- Polyketide_synthesis_cyclase_family wikiPageOutDegree "22".
- Polyketide_synthesis_cyclase_family wikiPageRevisionID "592827355".
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Actinobacteria.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Actinorhodin.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Active_site.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Alpha_helix.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Antiparallel_(biochemistry).
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Aromatic_hydrocarbon.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Bacteria.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Beta_sheet.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Biomolecular_structure.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Catalysis.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Category:Protein_families.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Cyclase.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Cyclase_(disambiguation).
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Ferredoxin.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Ferrodoxin.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Homodimer.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Polyaromatic.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Polyketide.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Polyketide_synthase.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Protein.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Protein_dimer.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Protein_folding.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Protein_subunit.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Proteins.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Secondary_structure.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Species.
- Polyketide_synthesis_cyclase_family wikiPageWikiLink Streptomyces_coelicolor.
- Polyketide_synthesis_cyclase_family caption "structural and functional analysis of tetracenomycin f2 cyclase from streptomyces glaucescens: a type-ii polyketide cyclase".
- Polyketide_synthesis_cyclase_family hasPhotoCollection Polyketide_synthesis_cyclase_family.
- Polyketide_synthesis_cyclase_family interpro "IPR006765".
- Polyketide_synthesis_cyclase_family name "Cyclase_polyket".
- Polyketide_synthesis_cyclase_family pfam "PF04673".
- Polyketide_synthesis_cyclase_family symbol "Cyclase_polyket".
- Polyketide_synthesis_cyclase_family wikiPageUsesTemplate Template:Infobox_protein_family.
- Polyketide_synthesis_cyclase_family wikiPageUsesTemplate Template:InterPro_content.
- Polyketide_synthesis_cyclase_family wikiPageUsesTemplate Template:Reflist.
- Polyketide_synthesis_cyclase_family subject Category:Protein_families.
- Polyketide_synthesis_cyclase_family type Biomolecule.
- Polyketide_synthesis_cyclase_family type Protein.
- Polyketide_synthesis_cyclase_family type Chemical.
- Polyketide_synthesis_cyclase_family type Thing.
- Polyketide_synthesis_cyclase_family type Q206229.
- Polyketide_synthesis_cyclase_family type Q8054.
- Polyketide_synthesis_cyclase_family comment "In molecular biology, the polyketide synthesis cyclase family of proteins includes a number of cyclases involved in polyketide synthesis in a number of actinobacterial species.Aromatic polyketides are assembled by a type II (iterative) polyketide synthase in bacteria. Iterative type II polyketide synthases produce polyketide chains of variable but defined length from a specific starter unit and a number of extender units.".
- Polyketide_synthesis_cyclase_family label "Polyketide synthesis cyclase family".
- Polyketide_synthesis_cyclase_family sameAs m.0h1brmw.
- Polyketide_synthesis_cyclase_family sameAs Q7226511.
- Polyketide_synthesis_cyclase_family sameAs Q7226511.
- Polyketide_synthesis_cyclase_family wasDerivedFrom Polyketide_synthesis_cyclase_family?oldid=592827355.
- Polyketide_synthesis_cyclase_family depiction PDB_1tuw_EBI.jpg.
- Polyketide_synthesis_cyclase_family isPrimaryTopicOf Polyketide_synthesis_cyclase_family.