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- Peptide_T abstract "Peptide T is an HIV entry inhibitor discovered in 1986 by researchers at the National Institutes of Health in the United States. Peptide T, and its modified analog Dala1-peptide T-amide (DAPTA), a drug in clinical trials, is a short peptide derived from the HIV envelope protein gp120 which blocks binding and infection of viral strains which use the CCR5 receptor to infect cells.Peptide T has several positive effects related to HIV disease and Neuro-AIDS. A placebo-controlled, three site, 200+ patient NIH-funded clinical trial, which focused on neurocognitive improvements, was conducted between 1990 and 1995. The results showed that peptide T was not significantly different from placebo on the study primary end points. However, peptide T was associated with improved performance in the subgroup of patients with more severe cognitive impairment.A long-delayed analysis of antiviral effects from the 1996 NIH study showed peripheral viral load (combined plasma and serum) was significantly reduced in the DAPTA-treated group. An eleven person study for peptide T effects on cellular viral load showed reductions in the persistently infected monocyte reservoir to undetectable levels in most of the patients. Elimination of viral reservoirs, such as the monocytes, is an important treatment goal. DAPTA has been shown to substantially suppress brain inflammation and block proinflammatory cytokine signaling pathways in a small animal model of Alzheimer's disease.".
- Peptide_T iupacName "(L)-Alanyl-(L)-seryl-(L)-threonyl-(L)-threonyl-(L)-threonyl-(L)-asparaginyl-(L)-tyrosyl-(L)-threonine".
- Peptide_T thumbnail Peptide_T.svg?width=300.
- Peptide_T wikiPageID "20097680".
- Peptide_T wikiPageLength "8145".
- Peptide_T wikiPageOutDegree "18".
- Peptide_T wikiPageRevisionID "673311136".
- Peptide_T wikiPageWikiLink Alzheimers_Disease.
- Peptide_T wikiPageWikiLink Alzheimers_disease.
- Peptide_T wikiPageWikiLink CCR5.
- Peptide_T wikiPageWikiLink Category:Entry_inhibitors.
- Peptide_T wikiPageWikiLink Category:Peptides.
- Peptide_T wikiPageWikiLink Clinical_trial.
- Peptide_T wikiPageWikiLink Dallas_Buyers_Club.
- Peptide_T wikiPageWikiLink Entry_inhibitor.
- Peptide_T wikiPageWikiLink Envelope_glycoprotein_GP120.
- Peptide_T wikiPageWikiLink Gp120.
- Peptide_T wikiPageWikiLink HIV.
- Peptide_T wikiPageWikiLink HIV-associated_neurocognitive_disorder.
- Peptide_T wikiPageWikiLink AIDS.
- Peptide_T wikiPageWikiLink Matthew_McConaughey.
- Peptide_T wikiPageWikiLink Monocyte.
- Peptide_T wikiPageWikiLink National_Institutes_of_Health.
- Peptide_T wikiPageWikiLink Neurocognitive.
- Peptide_T wikiPageWikiLink Placebo.
- Peptide_T wikiPageWikiLink Ron_Woodroof.
- Peptide_T wikiPageWikiLinkText "Peptide T".
- Peptide_T wikiPageWikiLinkText "peptide T".
- Peptide_T hasPhotoCollection Peptide_T.
- Peptide_T imagefile "Peptide T.svg".
- Peptide_T imagesize "250".
- Peptide_T iupacname "(L)-Alanyl-(L)-seryl-(L)-threonyl-(L)-threonyl-(L)-threonyl-(L)-asparaginyl-(L)-tyrosyl-(L)-threonine".
- Peptide_T wikiPageUsesTemplate Template:Chembox.
- Peptide_T wikiPageUsesTemplate Template:Reflist.
- Peptide_T subject Category:Entry_inhibitors.
- Peptide_T subject Category:Peptides.
- Peptide_T hypernym Inhibitor.
- Peptide_T type Biomolecule.
- Peptide_T type ChemicalCompound.
- Peptide_T type ChemicalSubstance.
- Peptide_T type Drug.
- Peptide_T type Biomolecule.
- Peptide_T type Drug.
- Peptide_T type Inhibitor.
- Peptide_T type Peptide.
- Peptide_T type ChemicalObject.
- Peptide_T type Thing.
- Peptide_T type Q11173.
- Peptide_T comment "Peptide T is an HIV entry inhibitor discovered in 1986 by researchers at the National Institutes of Health in the United States. Peptide T, and its modified analog Dala1-peptide T-amide (DAPTA), a drug in clinical trials, is a short peptide derived from the HIV envelope protein gp120 which blocks binding and infection of viral strains which use the CCR5 receptor to infect cells.Peptide T has several positive effects related to HIV disease and Neuro-AIDS.".
- Peptide_T label "Peptide T".
- Peptide_T sameAs پپتید_تی.
- Peptide_T sameAs m.04yf0hp.
- Peptide_T sameAs Peptid_T.
- Peptide_T sameAs Peptid_T.
- Peptide_T sameAs Q7166522.
- Peptide_T sameAs Q7166522.
- Peptide_T wasDerivedFrom Peptide_T?oldid=673311136.
- Peptide_T depiction Peptide_T.svg.
- Peptide_T isPrimaryTopicOf Peptide_T.