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- Pepstatin abstract "Pepstatin is a potent inhibitor of aspartyl proteases. It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence Isovaleryl-Val-Val-Sta-Ala-Sta (Iva-Val-Val-Sta-Ala-Sta). It was originally isolated from cultures of various species of Actinomyces due to its ability to inhibit pepsin at picomolar concentrations. Pepstatin A is well known to be an inhibitor of aspartic proteinases such as pepsin, cathepsins D and E. Except for its role as a proteinase inhibitor, however, the pharmacological action of pepstatin A upon cells remain unclear. Pepstatin A suppresses receptor activator of NF-κB ligand (RANKL)–induced osteoclast differentiation. Pepstatin A suppresses the formation of multinuclear osteoclasts dose-dependently. This inhibition of the formation only affected osteoclast cells, i.e., not osteoblast-like cells. Furthermore, pepstatin A also suppresses differentiation from pre-osteoclast cells to mononuclear osteoclast cells dose-dependently. This inhibition seems to be independent of the activities of proteinases such as cathepsin D, because the formation of osteoclasts was not suppressed with the concentration that inhibited the activity of cathepsin D. Cell signaling analysis indicated that the phosphorylation of ERK was inhibited in pepstatin A-treated cells, while the phosphorylation of IκB and Akt showed almost no change. Furthermore, pepstatin A decreased the expression of nuclear factor of activated T cells c1 (NFATc1). These results suggest that pepstatin A suppresses the differentiation of osteoclasts through the blockade of ERK signaling and the inhibition of NFATc1 expression.Pepstatin is practically insoluble in water, chloroform, ether, and benzene, however it can be dissolved in methanol, ethanol and DMSO with acetic acid, to between 1 and 5 mg/ml.".
- Pepstatin thumbnail Pepstatin.png?width=300.
- Pepstatin wikiPageExternalLink explore.do?structureId=1PSO.
- Pepstatin wikiPageID "12107810".
- Pepstatin wikiPageLength "4645".
- Pepstatin wikiPageOutDegree "7".
- Pepstatin wikiPageRevisionID "668561614".
- Pepstatin wikiPageWikiLink Actinomyces.
- Pepstatin wikiPageWikiLink Aspartate_protease.
- Pepstatin wikiPageWikiLink Aspartyl_protease.
- Pepstatin wikiPageWikiLink Category:Peptides.
- Pepstatin wikiPageWikiLink Pepsin.
- Pepstatin wikiPageWikiLink Peptide.
- Pepstatin wikiPageWikiLink Statine.
- Pepstatin wikiPageWikiLink File:PepstatinImg.jpg.
- Pepstatin wikiPageWikiLinkText "Pepstatin".
- Pepstatin wikiPageWikiLinkText "pepstatin A".
- Pepstatin wikiPageWikiLinkText "pepstatin".
- Pepstatin hasPhotoCollection Pepstatin.
- Pepstatin imagefile "Pepstatin.png".
- Pepstatin imagesize "300".
- Pepstatin othernames "Pepstatin A".
- Pepstatin verifiedfields "changed".
- Pepstatin verifiedrevid "464198597".
- Pepstatin wikiPageUsesTemplate Template:Chembox.
- Pepstatin wikiPageUsesTemplate Template:Clear_left.
- Pepstatin wikiPageUsesTemplate Template:For.
- Pepstatin subject Category:Peptides.
- Pepstatin hypernym Inhibitor.
- Pepstatin type Biomolecule.
- Pepstatin type ChemicalCompound.
- Pepstatin type ChemicalSubstance.
- Pepstatin type Biomolecule.
- Pepstatin type Chemical.
- Pepstatin type Peptide.
- Pepstatin type ChemicalObject.
- Pepstatin type Thing.
- Pepstatin type Q11173.
- Pepstatin comment "Pepstatin is a potent inhibitor of aspartyl proteases. It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence Isovaleryl-Val-Val-Sta-Ala-Sta (Iva-Val-Val-Sta-Ala-Sta). It was originally isolated from cultures of various species of Actinomyces due to its ability to inhibit pepsin at picomolar concentrations.".
- Pepstatin label "Pepstatin".
- Pepstatin sameAs پپستاتین.
- Pepstatin sameAs m.02vq26h.
- Pepstatin sameAs Pepstatin.
- Pepstatin sameAs Pepstatin.
- Pepstatin sameAs Q7166509.
- Pepstatin sameAs Q7166509.
- Pepstatin wasDerivedFrom Pepstatin?oldid=668561614.
- Pepstatin depiction Pepstatin.png.
- Pepstatin isPrimaryTopicOf Pepstatin.