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- Obesity_paradox abstract "Obesity paradox, also more inclusively known as reverse epidemiology, is a term for a medical hypothesis which holds that obesity (and high cholesterol, when the more global term reverse epidemiology is used) may, counterintuitively, be protective and associated with greater survival in certain groups of people, such as very elderly individuals or those with certain chronic diseases. It further postulates that normal to low body mass index or normal values of cholesterol may be detrimental and associated with higher mortality in asymptomatic people.The terminology reverse epidemiology was first proposed by Kamyar Kalantar-Zadeh in the journal Kidney International in 2003 and in the Journal of the American College of Cardiology in 2004. It is a contradiction to prevailing concepts of prevention of atherosclerosis and cardiovascular disease; however, active prophylactic treatment of heart disease in otherwise healthy, asymptomatic people is and has been controversial in the medical community for several years.The mechanism responsible for this reversed association is unknown, but it has been suggested that, in chronic kidney disease patients, "The common occurrence of persistent inflammation and protein energy wasting in advanced CKD seems to a large extent to account for this paradoxical association between traditional risk factors and CV outcomes in this patient population."The obesity paradox (excluding cholesterol paradox) was first described in 1999 in overweight and obese people undergoing hemodialysis, and has subsequently been found in those with heart failure, myocardial infarction, and acute coronary syndrome.In people with heart failure, those with a body mass index between 30.0–34.9 had lower mortality than those with a normal weight. This has been attributed to the fact that people often lose weight as they become progressively more ill. Similar findings have been made in other types of heart disease. People with class I obesity and heart disease do not have greater rates of further heart problems than people of normal weight who also have heart disease. In people with greater degrees of obesity, however, risk of further events is increased. Even after cardiac bypass surgery, no increase in mortality is seen in the overweight and obese. One study found that the improved survival could be explained by the more aggressive treatment obese people receive after a cardiac event. Another found that if one takes into account chronic obstructive pulmonary disease (COPD) in those with PAD the benefit of obesity no longer exists.".
- Obesity_paradox wikiPageExternalLink obesity-paradox-thin-not-in-for-type-2-diabetes.
- Obesity_paradox wikiPageID "18640324".
- Obesity_paradox wikiPageLength "9960".
- Obesity_paradox wikiPageOutDegree "28".
- Obesity_paradox wikiPageRevisionID "680549517".
- Obesity_paradox wikiPageWikiLink Acute_coronary_syndrome.
- Obesity_paradox wikiPageWikiLink Atherosclerosis.
- Obesity_paradox wikiPageWikiLink Body_mass_index.
- Obesity_paradox wikiPageWikiLink Cardiovascular_disease.
- Obesity_paradox wikiPageWikiLink Category:Epidemiology.
- Obesity_paradox wikiPageWikiLink Category:Hypotheses.
- Obesity_paradox wikiPageWikiLink Category:Obesity.
- Obesity_paradox wikiPageWikiLink Cholesterol.
- Obesity_paradox wikiPageWikiLink Chronic_condition.
- Obesity_paradox wikiPageWikiLink Chronic_disease.
- Obesity_paradox wikiPageWikiLink Chronic_kidney_disease.
- Obesity_paradox wikiPageWikiLink Chronic_obstructive_pulmonary_disease.
- Obesity_paradox wikiPageWikiLink Coronary_artery_bypass_surgery.
- Obesity_paradox wikiPageWikiLink Counterintuitive.
- Obesity_paradox wikiPageWikiLink Heart_failure.
- Obesity_paradox wikiPageWikiLink Hypercholesterolemia.
- Obesity_paradox wikiPageWikiLink Hypothesis.
- Obesity_paradox wikiPageWikiLink Journal_of_the_American_College_of_Cardiology.
- Obesity_paradox wikiPageWikiLink Kamyar_Kalantar-Zadeh.
- Obesity_paradox wikiPageWikiLink Kidney_International.
- Obesity_paradox wikiPageWikiLink Mortality_rate.
- Obesity_paradox wikiPageWikiLink Myocardial_infarction.
- Obesity_paradox wikiPageWikiLink Obesity.
- Obesity_paradox wikiPageWikiLink Obesity_paradox.
- Obesity_paradox wikiPageWikiLink Preventive_healthcare.
- Obesity_paradox wikiPageWikiLink Prophylaxis.
- Obesity_paradox wikiPageWikiLink Reverse_epidemiology.
- Obesity_paradox wikiPageWikiLink WebMD.
- Obesity_paradox wikiPageWikiLinkText "Obesity paradox".
- Obesity_paradox wikiPageWikiLinkText "obesity paradox".
- Obesity_paradox hasPhotoCollection Obesity_paradox.
- Obesity_paradox wikiPageUsesTemplate Template:Cite_journal.
- Obesity_paradox wikiPageUsesTemplate Template:Reflist.
- Obesity_paradox subject Category:Epidemiology.
- Obesity_paradox subject Category:Hypotheses.
- Obesity_paradox subject Category:Obesity.
- Obesity_paradox hypernym Term.
- Obesity_paradox comment "Obesity paradox, also more inclusively known as reverse epidemiology, is a term for a medical hypothesis which holds that obesity (and high cholesterol, when the more global term reverse epidemiology is used) may, counterintuitively, be protective and associated with greater survival in certain groups of people, such as very elderly individuals or those with certain chronic diseases.".
- Obesity_paradox label "Obesity paradox".
- Obesity_paradox sameAs Adipositas-Paradoxon.
- Obesity_paradox sameAs m.04gsxv2.
- Obesity_paradox sameAs Q357496.
- Obesity_paradox sameAs Q357496.
- Obesity_paradox wasDerivedFrom Obesity_paradox?oldid=680549517.
- Obesity_paradox isPrimaryTopicOf Obesity_paradox.