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- Necroptosis abstract "Necroptosis is a programmed form of necrosis, or inflammatory cell death. Conventionally, necrosis is associated with unprogrammed cell death resulting from cellular damage or infiltration by pathogens, in contrast to orderly, programmed cell death via apoptosis. The discovery of necroptosis showed that cells can execute necrosis in a programmed fashion and that apoptosis is not always preferable to necrotic cell death. Furthermore, the immunogenic nature of necroptosis favors its use in certain circumstances, such as aiding targeting of pathogens by the immune system. Necroptosis is well defined as a viral defense mechanism, allowing the cell to undergo “cellular suicide” in a caspase-independent fashion in the presence of viral caspase inhibitors. In addition to being a response to disease, necroptosis has also been characterized as a component of inflammatory diseases such as Crohn’s disease, pancreatitis, and myocardial infarction.The signaling pathway responsible for carrying out necroptosis is generally understood. Production of TNFα during viral infection leads to stimulation of its receptor TNFR1. The TNFR-associated death protein TRADD signals to RIPK1 which recruits RIPK3 forming the necrosome. Phosphorylation of MLKL by the Ripoptosome drives oligomerization of MLKL, allowing MLKL to insert into and permeabilize plasma membranes and organelles. Integration of MLKL leads to the inflammatory phenotype and release of DAMPS (Damage-Associated Molecular Patterns), which elicit immune responses.".
- Necroptosis thumbnail Necroptosis_Pathway_Diagram.png?width=300.
- Necroptosis wikiPageID "37431639".
- Necroptosis wikiPageLength "11185".
- Necroptosis wikiPageOutDegree "25".
- Necroptosis wikiPageRevisionID "654867136".
- Necroptosis wikiPageWikiLink Adenosine_triphosphate.
- Necroptosis wikiPageWikiLink Apoptosis.
- Necroptosis wikiPageWikiLink Caspase.
- Necroptosis wikiPageWikiLink Category:Cellular_processes.
- Necroptosis wikiPageWikiLink Category:Medical_aspects_of_death.
- Necroptosis wikiPageWikiLink Ciclosporin.
- Necroptosis wikiPageWikiLink Crohns_disease.
- Necroptosis wikiPageWikiLink Crohn’s_disease.
- Necroptosis wikiPageWikiLink Cyclosporine.
- Necroptosis wikiPageWikiLink Cytochrome_c.
- Necroptosis wikiPageWikiLink DNA_damage.
- Necroptosis wikiPageWikiLink DNA_repair.
- Necroptosis wikiPageWikiLink Homeostasis.
- Necroptosis wikiPageWikiLink Human_cytomegalovirus.
- Necroptosis wikiPageWikiLink Immune_system.
- Necroptosis wikiPageWikiLink Ischemia-reperfusion_injury.
- Necroptosis wikiPageWikiLink Mitochondria.
- Necroptosis wikiPageWikiLink Mitochondrion.
- Necroptosis wikiPageWikiLink Myocardial_infarction.
- Necroptosis wikiPageWikiLink NF-kB.
- Necroptosis wikiPageWikiLink NF-κB.
- Necroptosis wikiPageWikiLink Necrosis.
- Necroptosis wikiPageWikiLink Pancreatitis.
- Necroptosis wikiPageWikiLink Phagocytosis.
- Necroptosis wikiPageWikiLink Pinocytosis.
- Necroptosis wikiPageWikiLink TNFα.
- Necroptosis wikiPageWikiLink Toll-like_receptor.
- Necroptosis wikiPageWikiLink Toll-like_receptors.
- Necroptosis wikiPageWikiLink Tumor_necrosis_factor_alpha.
- Necroptosis wikiPageWikiLink File:Necroptosis_Pathway_Diagram.png.
- Necroptosis wikiPageWikiLinkText "Necroptosis".
- Necroptosis wikiPageWikiLinkText "necroptosis".
- Necroptosis hasPhotoCollection Necroptosis.
- Necroptosis wikiPageUsesTemplate Template:Reflist.
- Necroptosis subject Category:Cellular_processes.
- Necroptosis subject Category:Medical_aspects_of_death.
- Necroptosis hypernym Form.
- Necroptosis type Process.
- Necroptosis comment "Necroptosis is a programmed form of necrosis, or inflammatory cell death. Conventionally, necrosis is associated with unprogrammed cell death resulting from cellular damage or infiltration by pathogens, in contrast to orderly, programmed cell death via apoptosis. The discovery of necroptosis showed that cells can execute necrosis in a programmed fashion and that apoptosis is not always preferable to necrotic cell death.".
- Necroptosis label "Necroptosis".
- Necroptosis sameAs Nekroptose.
- Necroptosis sameAs Nécrose_programmée.
- Necroptosis sameAs m.0nb80qm.
- Necroptosis sameAs Некроптоз.
- Necroptosis sameAs Q3346925.
- Necroptosis sameAs Q3346925.
- Necroptosis wasDerivedFrom Necroptosis?oldid=654867136.
- Necroptosis depiction Necroptosis_Pathway_Diagram.png.
- Necroptosis isPrimaryTopicOf Necroptosis.