Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/N-Acetylserotonin> ?p ?o }
- N-Acetylserotonin abstract "N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase (AANAT) and is converted to melatonin by acetylserotonin O-methyltransferase (ASMT). Like melatonin, NAS is an agonist at the melatonin receptors MT1, MT2, and MT3, and may be considered to be a neurotransmitter. In addition, NAS is distributed in some areas of the brain where serotonin and melatonin are not, suggesting that it may have unique central duties of its own instead of merely functioning as a precursor in the synthesis of melatonin. NAS is able to penetrate the blood–brain barrier, unlike serotonin. NAS is known to have anti-depressant, neurotrophic and cognition-enhancing effects and has been proposed to be a target for the treatment of aging-associated cognitive decline and depression NAS may play a role in the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs). The SSRI fluoxetine and the MAO-A inhibitor clorgyline upregulate AANAT indirectly through serotonergic mechanisms and thereby increase NAS levels after chronic administration, and this correlates with the onset of their antidepressant effects. Furthermore, light exposure inhibits the synthesis of NAS and reduces the antidepressant effects of MAOIs. In addition, AANAT knockout mice display significantly greater immobility times versus control mice in animal models of depression. These data support a potential role for NAS in mood regulation and in antidepressant-induced therapeutic benefits.Through a currently unidentified mechanism, NAS may be the cause of the orthostatic hypotension seen with clinical treatment of MAOIs. It reduces blood pressure in rodents, and pinealectomy (the pineal gland being a major site of NAS and melatonin synthesis) abolishes the hypotensive effects of clorgyline. Why orthostatic hypotension is commonly seen with MAOIs but not SSRIs (both of which increase NAS levels) however, is unknown.".
- N-Acetylserotonin iupacName "N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide".
- N-Acetylserotonin thumbnail N-Acetylserotonin.png?width=300.
- N-Acetylserotonin wikiPageID "11395125".
- N-Acetylserotonin wikiPageLength "12161".
- N-Acetylserotonin wikiPageOutDegree "59".
- N-Acetylserotonin wikiPageRevisionID "678977838".
- N-Acetylserotonin wikiPageWikiLink 6-Hydroxymelatonin.
- N-Acetylserotonin wikiPageWikiLink 7,8-Dihydroxyflavone.
- N-Acetylserotonin wikiPageWikiLink Acetylserotonin_O-methyltransferase.
- N-Acetylserotonin wikiPageWikiLink Agonist.
- N-Acetylserotonin wikiPageWikiLink Amitriptyline.
- N-Acetylserotonin wikiPageWikiLink Animal_model.
- N-Acetylserotonin wikiPageWikiLink Anti-inflammatory.
- N-Acetylserotonin wikiPageWikiLink Anti-oxidant.
- N-Acetylserotonin wikiPageWikiLink Antioxidant.
- N-Acetylserotonin wikiPageWikiLink Aralkylamine_N-acetyltransferase.
- N-Acetylserotonin wikiPageWikiLink Blood_pressure.
- N-Acetylserotonin wikiPageWikiLink Brain.
- N-Acetylserotonin wikiPageWikiLink Category:Acetamides.
- N-Acetylserotonin wikiPageWikiLink Category:Antioxidants.
- N-Acetylserotonin wikiPageWikiLink Category:Biogenic_amines.
- N-Acetylserotonin wikiPageWikiLink Category:Circadian_rhythm.
- N-Acetylserotonin wikiPageWikiLink Category:Hormones_of_the_pineal_gland.
- N-Acetylserotonin wikiPageWikiLink Category:Melatonin_receptor_agonists.
- N-Acetylserotonin wikiPageWikiLink Category:Phenols.
- N-Acetylserotonin wikiPageWikiLink Category:TrkB_receptor_agonists.
- N-Acetylserotonin wikiPageWikiLink Category:Tryptamine_alkaloids.
- N-Acetylserotonin wikiPageWikiLink Chemical_compound.
- N-Acetylserotonin wikiPageWikiLink Chemical_synthesis.
- N-Acetylserotonin wikiPageWikiLink Clorgiline.
- N-Acetylserotonin wikiPageWikiLink Clorgyline.
- N-Acetylserotonin wikiPageWikiLink Downregulation_and_upregulation.
- N-Acetylserotonin wikiPageWikiLink Endogenous.
- N-Acetylserotonin wikiPageWikiLink Endogeny_(biology).
- N-Acetylserotonin wikiPageWikiLink Enzyme.
- N-Acetylserotonin wikiPageWikiLink Enzyme_inhibitor.
- N-Acetylserotonin wikiPageWikiLink Fluoxetine.
- N-Acetylserotonin wikiPageWikiLink HIOC.
- N-Acetylserotonin wikiPageWikiLink Hypotension.
- N-Acetylserotonin wikiPageWikiLink Hypotensive.
- N-Acetylserotonin wikiPageWikiLink Knockout_mouse.
- N-Acetylserotonin wikiPageWikiLink Lipid_peroxidation.
- N-Acetylserotonin wikiPageWikiLink Lipopolysaccharide.
- N-Acetylserotonin wikiPageWikiLink MAO-A.
- N-Acetylserotonin wikiPageWikiLink MT1_receptor.
- N-Acetylserotonin wikiPageWikiLink MT2_receptor.
- N-Acetylserotonin wikiPageWikiLink MT3_receptor.
- N-Acetylserotonin wikiPageWikiLink Major_depressive_disorder.
- N-Acetylserotonin wikiPageWikiLink Melatonin.
- N-Acetylserotonin wikiPageWikiLink Melatonin_receptor.
- N-Acetylserotonin wikiPageWikiLink Melatonin_receptor_1A.
- N-Acetylserotonin wikiPageWikiLink Melatonin_receptor_1B.
- N-Acetylserotonin wikiPageWikiLink Melatonin_receptor_1C.
- N-Acetylserotonin wikiPageWikiLink Model_organism.
- N-Acetylserotonin wikiPageWikiLink Monoamine_oxidase_A.
- N-Acetylserotonin wikiPageWikiLink Monoamine_oxidase_inhibitor.
- N-Acetylserotonin wikiPageWikiLink Natural_product.
- N-Acetylserotonin wikiPageWikiLink Neurotransmitter.
- N-Acetylserotonin wikiPageWikiLink Nitric_oxide_synthase.
- N-Acetylserotonin wikiPageWikiLink Orthostatic_hypotension.
- N-Acetylserotonin wikiPageWikiLink Pineal_gland.
- N-Acetylserotonin wikiPageWikiLink Pinealectomy.
- N-Acetylserotonin wikiPageWikiLink Potency_(pharmacology).
- N-Acetylserotonin wikiPageWikiLink Precursor_(biochemistry).
- N-Acetylserotonin wikiPageWikiLink Precursor_(chemistry).
- N-Acetylserotonin wikiPageWikiLink Progenitor_cell.
- N-Acetylserotonin wikiPageWikiLink Proinflammatory_cytokine.
- N-Acetylserotonin wikiPageWikiLink Reaction_intermediate.
- N-Acetylserotonin wikiPageWikiLink Reactive_oxygen_species.
- N-Acetylserotonin wikiPageWikiLink Selective_serotonin_reuptake_inhibitor.
- N-Acetylserotonin wikiPageWikiLink Serotonergic.
- N-Acetylserotonin wikiPageWikiLink Serotonin.
- N-Acetylserotonin wikiPageWikiLink Synthesis_(chemical).
- N-Acetylserotonin wikiPageWikiLink TrkB_receptor.
- N-Acetylserotonin wikiPageWikiLink Tropomyosin_receptor_kinase_B.
- N-Acetylserotonin wikiPageWikiLink Tumor_necrosis_factor_alpha.
- N-Acetylserotonin wikiPageWikiLink Upregulation.
- N-Acetylserotonin wikiPageWikiLinkText "''N''-Acetylserotonin".
- N-Acetylserotonin wikiPageWikiLinkText "N-Acetylserotonin (normelatonin)".
- N-Acetylserotonin wikiPageWikiLinkText "N-Acetylserotonin".
- N-Acetylserotonin hasPhotoCollection N-Acetylserotonin.
- N-Acetylserotonin imagefile "N-Acetylserotonin-3D-sticks.png".
- N-Acetylserotonin imagefile "N-Acetylserotonin.png".
- N-Acetylserotonin iupacname "N-[2-ethyl]acetamide".
- N-Acetylserotonin name "N-Acetylserotonin".
- N-Acetylserotonin othernames "N-acetyl-5-hydroxytryptamine, N-acetyl-5-HT".
- N-Acetylserotonin verifiedfields "changed".
- N-Acetylserotonin verifiedrevid "462257090".
- N-Acetylserotonin watchedfields "changed".
- N-Acetylserotonin wikiPageUsesTemplate Template:Antioxidants.
- N-Acetylserotonin wikiPageUsesTemplate Template:Chembox.
- N-Acetylserotonin wikiPageUsesTemplate Template:Melatonergics.
- N-Acetylserotonin wikiPageUsesTemplate Template:Neurotransmitters.
- N-Acetylserotonin wikiPageUsesTemplate Template:Neurotrophinergics.
- N-Acetylserotonin wikiPageUsesTemplate Template:Reflist.
- N-Acetylserotonin wikiPageUsesTemplate Template:Tryptamines.
- N-Acetylserotonin subject Category:Acetamides.
- N-Acetylserotonin subject Category:Antioxidants.
- N-Acetylserotonin subject Category:Biogenic_amines.