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- Missing_heritability_problem abstract "The "missing heritability" problem can be defined as the fact that single genetic variations cannot account for much of the heritability of diseases, behaviors, and other phenotypes. This is a problem that has significant implications for medicine, since a person's susceptibility to disease may depend more on "the combined effect of all the genes in the background than on the disease genes in the foreground".A model has been introduced that takes into account epigenetic inheritance on the risk and recurrence risk of a complex disease.The limiting pathway (LP) model has been introduced in which a trait depends on the value of k inputs that can have rate limitations due to stoichiometric ratios, reactants required in a biochemical pathway, or proteins required for transcription of a gene. Each of these k inputs is a strictly additive trait that depends on a set of common or rare variants. When k = 1, the LP model is simply a standard additive trait.The missing heritability is only missing if the reason for the heritability of a trait across many cultures/ecologies or geographic regions is the same, that is, only if the same alleles are effecting the observed heritability. However high and however consistent the heritability the genes behind it (the genes effecting it) may vary with the population.".
- Missing_heritability_problem wikiPageID "34853851".
- Missing_heritability_problem wikiPageLength "4502".
- Missing_heritability_problem wikiPageOutDegree "8".
- Missing_heritability_problem wikiPageRevisionID "679447945".
- Missing_heritability_problem wikiPageWikiLink Category:Epigenetics.
- Missing_heritability_problem wikiPageWikiLink Category:Genetics.
- Missing_heritability_problem wikiPageWikiLink Epigenetic.
- Missing_heritability_problem wikiPageWikiLink Epigenetics.
- Missing_heritability_problem wikiPageWikiLink Heritability.
- Missing_heritability_problem wikiPageWikiLink Phenotype.
- Missing_heritability_problem wikiPageWikiLink Phenotypic_trait.
- Missing_heritability_problem wikiPageWikiLink Stoichiometry.
- Missing_heritability_problem wikiPageWikiLink Susceptible_individual.
- Missing_heritability_problem wikiPageWikiLink Trait_(biology).
- Missing_heritability_problem wikiPageWikiLinkText "Missing heritability problem".
- Missing_heritability_problem hasPhotoCollection Missing_heritability_problem.
- Missing_heritability_problem wikiPageUsesTemplate Template:Reflist.
- Missing_heritability_problem subject Category:Epigenetics.
- Missing_heritability_problem subject Category:Genetics.
- Missing_heritability_problem type Article.
- Missing_heritability_problem type Article.
- Missing_heritability_problem type Epigenetic.
- Missing_heritability_problem comment "The "missing heritability" problem can be defined as the fact that single genetic variations cannot account for much of the heritability of diseases, behaviors, and other phenotypes.".
- Missing_heritability_problem label "Missing heritability problem".
- Missing_heritability_problem sameAs Heredabilidad_perdida.
- Missing_heritability_problem sameAs m.0j43n2t.
- Missing_heritability_problem sameAs Q3083720.
- Missing_heritability_problem sameAs Q3083720.
- Missing_heritability_problem wasDerivedFrom Missing_heritability_problem?oldid=679447945.
- Missing_heritability_problem isPrimaryTopicOf Missing_heritability_problem.