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- Mir-15_microRNA_precursor_family abstract "The miR-15 microRNA precursor family is made up of small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences, as well as miR-16-1, miR-16-2, miR-195 and miR-497. These six highly conserved miRNAs are clustered on three separate chromosomes. In humans miR-15a and miR-16 are clustered within 0.5 kilobases at chromosome position 13q14. This region has been found to be the most commonly affected in chronic lymphocytic leukaemia (CLL), with deletions of the entire region in more than half of cases. Both miR-15a and miR-16 are thus frequently deleted or down-regulated in CLL samples with 13q14 deletions; occurring in more than two thirds of CLL cases.miR-15a/16-1 deletion has been shown to accelerate the proliferation of both human and mouse B-cells through modulation of the expression of genes controlling cell cycle progression. Studies have found the miR-15a/16-1 microRNA cluster to function as a tumour suppressor, with the oncogene BCL2 as its target. Specifically, miR-15a/16-1 downregulates BCL2 expression and is itself deleted or downregulated in tumour cells. There is a marked increase in BCL2 levels observed in advanced prostate tumour cases, which is inversely correlated with miR-15a/16-1 expression (and so corresponds to a decrease in miR-15a/16-1 levels). Inhibition of cell proliferation by the miR-15a/16-1 cluster occurs in both lymphoid and non-lymphoid tissue.The miR-15a/16-1 cluster has further been found to be highly expressed in CD5+ cells, therefore hinting at an important role of miR-15/16 in normal CD5+ B-cell homeostasis.".
- Mir-15_microRNA_precursor_family thumbnail RF00455.jpg?width=300.
- Mir-15_microRNA_precursor_family wikiPageExternalLink mirna_entry.pl?acc=MI0000069.
- Mir-15_microRNA_precursor_family wikiPageExternalLink mirna_entry.pl?acc=MI0000438.
- Mir-15_microRNA_precursor_family wikiPageID "11421212".
- Mir-15_microRNA_precursor_family wikiPageLength "10235".
- Mir-15_microRNA_precursor_family wikiPageOutDegree "18".
- Mir-15_microRNA_precursor_family wikiPageRevisionID "678972077".
- Mir-15_microRNA_precursor_family wikiPageWikiLink B-cell_chronic_lymphocytic_leukemia.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Binucleated_cells.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Biomolecular_structure.
- Mir-15_microRNA_precursor_family wikiPageWikiLink CHEK1.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Category:MicroRNA.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Category:MicroRNA_precursor_families.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Cell_growth.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Cell_proliferation.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Chk1.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Conserved_sequence.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Eukaryota.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Eukaryote.
- Mir-15_microRNA_precursor_family wikiPageWikiLink G2_phase.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Gene.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Homeostasis.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Hypertrophy.
- Mir-15_microRNA_precursor_family wikiPageWikiLink MicroRNA.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Non-coding_RNA.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Oncogene.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Secondary_structure.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Sequence_conservation.
- Mir-15_microRNA_precursor_family wikiPageWikiLink Untranslated_region.
- Mir-15_microRNA_precursor_family wikiPageWikiLinkText "miR-15".
- Mir-15_microRNA_precursor_family wikiPageWikiLinkText "miR-16".
- Mir-15_microRNA_precursor_family wikiPageWikiLinkText "mir-15 microRNA precursor family".
- Mir-15_microRNA_precursor_family caption "Predicted secondary structure and sequence conservation of mir-15".
- Mir-15_microRNA_precursor_family hasPhotoCollection Mir-15_microRNA_precursor_family.
- Mir-15_microRNA_precursor_family id "RF00455".
- Mir-15_microRNA_precursor_family mirbase "MI0000069".
- Mir-15_microRNA_precursor_family mirbaseFamily "MIPF0000006".
- Mir-15_microRNA_precursor_family name "mir-15 microRNA precursor family".
- Mir-15_microRNA_precursor_family rfam "RF00455".
- Mir-15_microRNA_precursor_family rnaType Gene.
- Mir-15_microRNA_precursor_family rnaType MicroRNA.
- Mir-15_microRNA_precursor_family symbol "mir-15".
- Mir-15_microRNA_precursor_family taxDomain Eukaryota.
- Mir-15_microRNA_precursor_family taxDomain Eukaryote.
- Mir-15_microRNA_precursor_family wikiPageUsesTemplate Template:Cite_journal.
- Mir-15_microRNA_precursor_family wikiPageUsesTemplate Template:Infobox_rfam.
- Mir-15_microRNA_precursor_family wikiPageUsesTemplate Template:MiRNA_precursor_families.
- Mir-15_microRNA_precursor_family wikiPageUsesTemplate Template:Reflist.
- Mir-15_microRNA_precursor_family wikiPageUsesTemplate Template:Rfam.
- Mir-15_microRNA_precursor_family subject Category:MicroRNA.
- Mir-15_microRNA_precursor_family subject Category:MicroRNA_precursor_families.
- Mir-15_microRNA_precursor_family comment "The miR-15 microRNA precursor family is made up of small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences, as well as miR-16-1, miR-16-2, miR-195 and miR-497. These six highly conserved miRNAs are clustered on three separate chromosomes. In humans miR-15a and miR-16 are clustered within 0.5 kilobases at chromosome position 13q14.".
- Mir-15_microRNA_precursor_family label "Mir-15 microRNA precursor family".
- Mir-15_microRNA_precursor_family sameAs m.02rbz56.
- Mir-15_microRNA_precursor_family sameAs Q6871668.
- Mir-15_microRNA_precursor_family sameAs Q6871668.
- Mir-15_microRNA_precursor_family wasDerivedFrom Mir-15_microRNA_precursor_family?oldid=678972077.
- Mir-15_microRNA_precursor_family depiction RF00455.jpg.
- Mir-15_microRNA_precursor_family isPrimaryTopicOf Mir-15_microRNA_precursor_family.