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- Methyllysine abstract "In proteins, the amino acid residue lysine can be methylated once, twice or thrice on its terminal sidechain ammonium group.Such methylated lysines play an important role in epigenetics; the methylation of specific lysines of certain histones in a nucleosome alters the binding of the surrounding DNA to those histones, which in turn affects the expression of genes on that DNA. The binding is affected because the effective radius of the positive charge is increased (methyl groups are larger than the hydrogen atoms they replace), reducing the strongest potential electrostatic attraction with the negatively charged DNA. Moreover, the methyl groups are themselves hydrophobic, and alter the structure of water in their vicinity, similar to tetramethyl ammonium (Jencks reference).It is thought that the methylation of lysine (and arginine) on histone tails does not directly affect their binding to DNA. Rather, such methyl marks recruit other proteins that modulate chromatin structure.In Protein Data Bank files, methylated lysines are indicated by the MLY or MLZ acronyms.".
- Methyllysine wikiPageID "9180437".
- Methyllysine wikiPageLength "1543".
- Methyllysine wikiPageOutDegree "10".
- Methyllysine wikiPageRevisionID "621614145".
- Methyllysine wikiPageWikiLink Amino_acid.
- Methyllysine wikiPageWikiLink Category:Basic_amino_acids.
- Methyllysine wikiPageWikiLink DNA.
- Methyllysine wikiPageWikiLink Electrostatic.
- Methyllysine wikiPageWikiLink Electrostatics.
- Methyllysine wikiPageWikiLink Epigenetics.
- Methyllysine wikiPageWikiLink Histone.
- Methyllysine wikiPageWikiLink Lysine.
- Methyllysine wikiPageWikiLink Nucleosome.
- Methyllysine wikiPageWikiLink Protein.
- Methyllysine wikiPageWikiLink Protein_Data_Bank.
- Methyllysine wikiPageWikiLinkText "Methyllysine".
- Methyllysine wikiPageWikiLinkText "dimethyl-".
- Methyllysine wikiPageWikiLinkText "methyl-".
- Methyllysine wikiPageWikiLinkText "methylated lysine residues".
- Methyllysine wikiPageWikiLinkText "methyllysine".
- Methyllysine wikiPageWikiLinkText "trimethyllysine".
- Methyllysine hasPhotoCollection Methyllysine.
- Methyllysine wikiPageUsesTemplate Template:Biochem-stub.
- Methyllysine wikiPageUsesTemplate Template:Refimprove.
- Methyllysine wikiPageUsesTemplate Template:Reflist.
- Methyllysine subject Category:Basic_amino_acids.
- Methyllysine type Article.
- Methyllysine type Article.
- Methyllysine comment "In proteins, the amino acid residue lysine can be methylated once, twice or thrice on its terminal sidechain ammonium group.Such methylated lysines play an important role in epigenetics; the methylation of specific lysines of certain histones in a nucleosome alters the binding of the surrounding DNA to those histones, which in turn affects the expression of genes on that DNA.".
- Methyllysine label "Methyllysine".
- Methyllysine sameAs Méthyllysine.
- Methyllysine sameAs メチルリシン.
- Methyllysine sameAs Methyllysine.
- Methyllysine sameAs m.027_dbp.
- Methyllysine sameAs Q6824025.
- Methyllysine sameAs Q6824025.
- Methyllysine wasDerivedFrom Methyllysine?oldid=621614145.
- Methyllysine isPrimaryTopicOf Methyllysine.