Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Lonidamine> ?p ?o }
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- Lonidamine abstract "Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites tumor cells showed that lonidamine inhibits both respiration and glycolysis leading to a decrease in cellular ATP.Clinical trials of lonidamine in combination with other anticancer agents for a variety of cancers has begun. This is due to its proven ability to inhibit energy metabolism in cancer cells, and to enhance the activity of anticancer agents.Lonidamine has been used in the treatment of brain tumours in combination with radiotherapy and temozolomide. Results showed that a combination of temozolomide and lonidamine at clinically achievable, low plasma concentrations, could inhibit tumour growth, and lonidamine could reduce the dose of temozolomide required for radiosensitization of brain tumours.A derivative of lonidamine, gamendazole, is in testing as a possible male contraceptive pill.".
- Lonidamine atcPrefix "L01".
- Lonidamine atcSuffix "XX07".
- Lonidamine casNumber "50264-69-2".
- Lonidamine fdaUniiCode "U78804BIDR".
- Lonidamine iupacName "1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid".
- Lonidamine pubchem "39562".
- Lonidamine thumbnail Lonidamine.svg?width=300.
- Lonidamine wikiPageID "20362464".
- Lonidamine wikiPageLength "4008".
- Lonidamine wikiPageOutDegree "6".
- Lonidamine wikiPageRevisionID "608373136".
- Lonidamine wikiPageWikiLink Category:Antineoplastic_drugs.
- Lonidamine wikiPageWikiLink Category:Indazoles.
- Lonidamine wikiPageWikiLink Contraceptive_pill.
- Lonidamine wikiPageWikiLink Gamendazole.
- Lonidamine wikiPageWikiLink Glycolysis.
- Lonidamine wikiPageWikiLink Hexokinase.
- Lonidamine wikiPageWikiLink Oral_contraceptive_pill.
- Lonidamine wikiPageWikiLinkText "Lonidamine".
- Lonidamine wikiPageWikiLinkText "lonidamine".
- Lonidamine atcPrefix "L01".
- Lonidamine atcSuffix "XX07".
- Lonidamine c "15".
- Lonidamine casNumber "50264".
- Lonidamine chemspiderid "36170".
- Lonidamine cl "2".
- Lonidamine h "10".
- Lonidamine hasPhotoCollection Lonidamine.
- Lonidamine inchi "1".
- Lonidamine inchikey "WDRYRZXSPDWGEB-UHFFFAOYAX".
- Lonidamine iupacName "1".
- Lonidamine kegg "D07257".
- Lonidamine molecularWeight "321.158".
- Lonidamine n "2".
- Lonidamine o "2".
- Lonidamine pubchem "39562".
- Lonidamine smiles "C1=CC=C2CCCO".
- Lonidamine stdinchi "1".
- Lonidamine stdinchikey "WDRYRZXSPDWGEB-UHFFFAOYSA-N".
- Lonidamine unii "U78804BIDR".
- Lonidamine verifiedrevid "444558328".
- Lonidamine watchedfields "changed".
- Lonidamine wikiPageUsesTemplate Template:Antineoplastic-drug-stub.
- Lonidamine wikiPageUsesTemplate Template:Chemotherapeutic_agents.
- Lonidamine wikiPageUsesTemplate Template:Drugbox.
- Lonidamine wikiPageUsesTemplate Template:Reflist.
- Lonidamine subject Category:Antineoplastic_drugs.
- Lonidamine subject Category:Indazoles.
- Lonidamine hypernym Derivative.
- Lonidamine type Article.
- Lonidamine type ChemicalSubstance.
- Lonidamine type Drug.
- Lonidamine type Article.
- Lonidamine type Chemical.
- Lonidamine type Drug.
- Lonidamine type Heterocycle.
- Lonidamine type ChemicalObject.
- Lonidamine type Thing.
- Lonidamine type Q8386.
- Lonidamine comment "Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase.".
- Lonidamine label "Lonidamine".
- Lonidamine sameAs Lonidamina.
- Lonidamine sameAs m.04zyy7s.
- Lonidamine sameAs Lonidamin.
- Lonidamine sameAs Lonidamin.
- Lonidamine sameAs Q3836670.
- Lonidamine sameAs Q3836670.
- Lonidamine wasDerivedFrom Lonidamine?oldid=608373136.
- Lonidamine depiction Lonidamine.svg.
- Lonidamine isPrimaryTopicOf Lonidamine.