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- Lirequinil abstract "Lirequinil (Ro41-3696) is a nonbenzodiazepine hypnotic drug which binds to benzodiazepine sites on the GABAA receptor. In human clinical trials, lirequinil was found to have similar efficacy to zolpidem, with less side effects such as clumsiness and memory impairment. However it was also much slower acting than zolpidem, with peak plasma concentrations not reached until 2.5 hours after oral administration, and its O-desethyl metabolite Ro41-3290 is also active with a half-life of 8 hours. This meant that while effective as a hypnotic, lirequinil failed to prove superior to zolpidem due to producing more next-day sedation, and it has not been adopted for clinical use. It was developed by a team at Hoffmann-La Roche in the 1990s.".
- Lirequinil atcPrefix "none".
- Lirequinil casNumber "143943-73-1".
- Lirequinil fdaUniiCode "2VUW1087AD".
- Lirequinil iupacName "10-chloro-1-[(3S)-3-ethoxypyrrolidine-1-carbonyl]-3-phenyl-6,7-dihydrobenzo[a]quinolizin-4-one".
- Lirequinil pubchem "3045375".
- Lirequinil thumbnail Lirequinil_structure.png?width=300.
- Lirequinil wikiPageID "28913346".
- Lirequinil wikiPageLength "4635".
- Lirequinil wikiPageOutDegree "9".
- Lirequinil wikiPageRevisionID "633375502".
- Lirequinil wikiPageWikiLink Category:GABAA_receptor_positive_allosteric_modulators.
- Lirequinil wikiPageWikiLink Category:Sedatives.
- Lirequinil wikiPageWikiLink Clinical_trial.
- Lirequinil wikiPageWikiLink Clinical_trials.
- Lirequinil wikiPageWikiLink GABAA_receptor.
- Lirequinil wikiPageWikiLink Hypnotic.
- Lirequinil wikiPageWikiLink Nonbenzodiazepine.
- Lirequinil wikiPageWikiLink Receptor_(biochemistry).
- Lirequinil wikiPageWikiLink Zolpidem.
- Lirequinil wikiPageWikiLink File:Ro41-3290_structure.png.
- Lirequinil wikiPageWikiLinkText "lirequinil".
- Lirequinil atcPrefix "none".
- Lirequinil c "26".
- Lirequinil casNumber "143943".
- Lirequinil chemspiderid "2308119".
- Lirequinil cl "1".
- Lirequinil h "25".
- Lirequinil hasPhotoCollection Lirequinil.
- Lirequinil inchi "1".
- Lirequinil inchikey "CBSWRAUYCIIUEI-FQEVSTJZBN".
- Lirequinil iupacName "10".
- Lirequinil molecularWeight "448.941".
- Lirequinil n "2".
- Lirequinil o "3".
- Lirequinil pubchem "3045375".
- Lirequinil smiles "CCO[C@H]1CCNCC2=C3C4=CC=CCCl".
- Lirequinil stdinchi "1".
- Lirequinil stdinchikey "CBSWRAUYCIIUEI-FQEVSTJZSA-N".
- Lirequinil unii "2".
- Lirequinil verifiedfields "changed".
- Lirequinil verifiedrevid "451564522".
- Lirequinil width "200".
- Lirequinil wikiPageUsesTemplate Template:Drugbox.
- Lirequinil wikiPageUsesTemplate Template:GABAAR_PAMs.
- Lirequinil wikiPageUsesTemplate Template:Hypnotics.
- Lirequinil wikiPageUsesTemplate Template:Reflist.
- Lirequinil subject Category:GABAA_receptor_positive_allosteric_modulators.
- Lirequinil subject Category:Sedatives.
- Lirequinil hypernym Drug.
- Lirequinil type Article.
- Lirequinil type ChemicalSubstance.
- Lirequinil type Drug.
- Lirequinil type Article.
- Lirequinil type Chemical.
- Lirequinil type Drug.
- Lirequinil type ChemicalObject.
- Lirequinil type Thing.
- Lirequinil type Q8386.
- Lirequinil comment "Lirequinil (Ro41-3696) is a nonbenzodiazepine hypnotic drug which binds to benzodiazepine sites on the GABAA receptor. In human clinical trials, lirequinil was found to have similar efficacy to zolpidem, with less side effects such as clumsiness and memory impairment. However it was also much slower acting than zolpidem, with peak plasma concentrations not reached until 2.5 hours after oral administration, and its O-desethyl metabolite Ro41-3290 is also active with a half-life of 8 hours.".
- Lirequinil label "Lirequinil".
- Lirequinil sameAs m.0dgn4lt.
- Lirequinil sameAs Lirehinil.
- Lirequinil sameAs Lirehinil.
- Lirequinil sameAs Q6557635.
- Lirequinil sameAs Q6557635.
- Lirequinil wasDerivedFrom Lirequinil?oldid=633375502.
- Lirequinil depiction Lirequinil_structure.png.
- Lirequinil isPrimaryTopicOf Lirequinil.