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- Interleukin_12_receptor,_beta_2_subunit abstract "Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 orthologs have been identified in all mammals for which complete genome data are available.The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and IL12Rβ1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12Rβ1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL12Rβ2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.".
- Interleukin_12_receptor,_beta_2_subunit entrezgene "3595".
- Interleukin_12_receptor,_beta_2_subunit wikiPageID "14773920".
- Interleukin_12_receptor,_beta_2_subunit wikiPageLength "9791".
- Interleukin_12_receptor,_beta_2_subunit wikiPageOutDegree "17".
- Interleukin_12_receptor,_beta_2_subunit wikiPageRevisionID "678929035".
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Crohns_disease.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Effector_(biology).
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Gene.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Gene_expression.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Homology_(biology).
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Interferon-gamma.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Interferon_gamma.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Interleukin-12_receptor.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Interleukin_12.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Interleukin_12_receptor.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Interleukin_12_receptor,_beta_1_subunit.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Janus_kinase_2.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Leprosy.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Mammal.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Mammals.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Orthologs.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Phosphorylation.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Protein-protein_interaction.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Protein–protein_interaction.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink STAT4.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink T_helper_cell.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLink Transmembrane_protein.
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLinkText "IL12-R β2".
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLinkText "IL12RB2".
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLinkText "IL12rβ2".
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLinkText "IR12RB2".
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLinkText "Interleukin 12 receptor, beta 2 subunit".
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLinkText "beta 2 subunit".
- Interleukin_12_receptor,_beta_2_subunit wikiPageWikiLinkText "beta 2 subunit, interleukin 12 receptor, beta 2".
- Interleukin_12_receptor,_beta_2_subunit hasPhotoCollection Interleukin_12_receptor,_beta_2_subunit.
- Interleukin_12_receptor,_beta_2_subunit requireManualInspection "no".
- Interleukin_12_receptor,_beta_2_subunit summaryText "The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and IL12Rβ1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12Rβ1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL12Rβ2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.".
- Interleukin_12_receptor,_beta_2_subunit updateCitations "yes".
- Interleukin_12_receptor,_beta_2_subunit updatePage "yes".
- Interleukin_12_receptor,_beta_2_subunit updateProteinBox "yes".
- Interleukin_12_receptor,_beta_2_subunit updateSummary "yes".
- Interleukin_12_receptor,_beta_2_subunit wikiPageUsesTemplate Template:Gene-1-stub.
- Interleukin_12_receptor,_beta_2_subunit wikiPageUsesTemplate Template:PBB.
- Interleukin_12_receptor,_beta_2_subunit wikiPageUsesTemplate Template:PBB_Controls.
- Interleukin_12_receptor,_beta_2_subunit wikiPageUsesTemplate Template:PBB_Further_reading.
- Interleukin_12_receptor,_beta_2_subunit wikiPageUsesTemplate Template:PBB_Summary.
- Interleukin_12_receptor,_beta_2_subunit wikiPageUsesTemplate Template:Refbegin.
- Interleukin_12_receptor,_beta_2_subunit wikiPageUsesTemplate Template:Refend.
- Interleukin_12_receptor,_beta_2_subunit wikiPageUsesTemplate Template:Reflist.
- Interleukin_12_receptor,_beta_2_subunit wikiPageUsesTemplate Template:Use_dmy_dates.
- Interleukin_12_receptor,_beta_2_subunit hypernym Subunit.
- Interleukin_12_receptor,_beta_2_subunit type Biomolecule.
- Interleukin_12_receptor,_beta_2_subunit type Protein.
- Interleukin_12_receptor,_beta_2_subunit type Thing.
- Interleukin_12_receptor,_beta_2_subunit type Q206229.
- Interleukin_12_receptor,_beta_2_subunit type Q8054.
- Interleukin_12_receptor,_beta_2_subunit comment "Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 orthologs have been identified in all mammals for which complete genome data are available.The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex.".
- Interleukin_12_receptor,_beta_2_subunit label "Interleukin 12 receptor, beta 2 subunit".
- Interleukin_12_receptor,_beta_2_subunit sameAs m.03gxk8t.
- Interleukin_12_receptor,_beta_2_subunit sameAs Q15996696.
- Interleukin_12_receptor,_beta_2_subunit sameAs Q15996696.
- Interleukin_12_receptor,_beta_2_subunit wasDerivedFrom Interleukin_12_receptor,_beta_2_subunit?oldid=678929035.
- Interleukin_12_receptor,_beta_2_subunit isPrimaryTopicOf Interleukin_12_receptor,_beta_2_subunit.