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- Interleukin-1_receptor–associated_kinase_4_deficiency abstract "Members of interleukin-1 receptor (Il-1R) and the Toll-like receptor superfamily share an intracytoplasmic Toll-IL-1 receptor (TLR) domain, which mediates recruitment of the interleukin-1 receptor-associated kinase (IRAK) complex via TIR-containing adapter molecules. Three unrelated, otherwise healthy children with recurrent pyogenic infections due to pneumococci and staphylococci had normal immunocompetence by standard immune studies. They had normal titers of antipneumococcal antibodies. However, their blood and fibroblast cells did not activate nuclear factor κB and mitogen-activated protein kinase and failed to induce downstream cytokines in response to any of the known ligands of TIR-bearing receptors. Each was found to have an inherited deficiency of IRAK-4. Thus, the TIR-IRAK signaling pathway appears to be crucial for protective immunity against specific bacteria but is redundant against most other microorganisms.".
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageID "28002621".
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageLength "1533".
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageOutDegree "11".
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageRevisionID "678929191".
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Category:Enzymes.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Category:Genetic_disorders_with_no_OMIM.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Cytokine.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Cytokines.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Fibroblast.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Fibroblast_cells.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink IRAK-4.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink IRAK4.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Interleukin-1_receptor-associated_kinase.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Microorganism.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Microorganisms.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Mitogen.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Pneumococci.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Staphylococci.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Staphylococcus.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Streptococcus_pneumoniae.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLink Toll-like_receptor.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageWikiLinkText "Interleukin-1 receptor–associated kinase 4 deficiency".
- Interleukin-1_receptor–associated_kinase_4_deficiency hasPhotoCollection Interleukin-1_receptor–associated_kinase_4_deficiency.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageUsesTemplate Template:Genetics-stub.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageUsesTemplate Template:Orphan.
- Interleukin-1_receptor–associated_kinase_4_deficiency wikiPageUsesTemplate Template:Reflist.
- Interleukin-1_receptor–associated_kinase_4_deficiency subject Category:Enzymes.
- Interleukin-1_receptor–associated_kinase_4_deficiency subject Category:Genetic_disorders_with_no_OMIM.
- Interleukin-1_receptor–associated_kinase_4_deficiency comment "Members of interleukin-1 receptor (Il-1R) and the Toll-like receptor superfamily share an intracytoplasmic Toll-IL-1 receptor (TLR) domain, which mediates recruitment of the interleukin-1 receptor-associated kinase (IRAK) complex via TIR-containing adapter molecules. Three unrelated, otherwise healthy children with recurrent pyogenic infections due to pneumococci and staphylococci had normal immunocompetence by standard immune studies. They had normal titers of antipneumococcal antibodies.".
- Interleukin-1_receptor–associated_kinase_4_deficiency label "Interleukin-1 receptor–associated kinase 4 deficiency".
- Interleukin-1_receptor–associated_kinase_4_deficiency sameAs m.0ch19m_.
- Interleukin-1_receptor–associated_kinase_4_deficiency sameAs Q5996465.
- Interleukin-1_receptor–associated_kinase_4_deficiency sameAs Q5996465.
- Interleukin-1_receptor–associated_kinase_4_deficiency wasDerivedFrom Interleukin-1_receptor–associated_kinase_4_deficiency?oldid=678929191.
- Interleukin-1_receptor–associated_kinase_4_deficiency isPrimaryTopicOf Interleukin-1_receptor–associated_kinase_4_deficiency.