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- In_vitro_to_in_vivo_extrapolation abstract "In vitro to in vivo extrapolation refers to the qualitative or quantitative transposition of experimental results or observations made in vitro to predicts phenomena in vivo, on full living organisms.The problem of transposing in vitro results is particularly acute in areas such as toxicology where animal experiments are being increasingly replaced by alternative tests.Results obtained from in vitro experiments cannot usually be transposed as is to predict the reaction of an entire organism in vivo. Build a consistent and reliable extrapolation procedure from in vitro results to in vitro is therefore extremely important. Two solutions are now commonly accepted:(1) Increasing the complexity of in vitro systems to reproduce tissues and interactions between them (as in “human on chip” systems).(2) Using mathematical modeling to numerically simulate the behavior of the complex system, the in vitro data providing model parameter values.The two approaches are not incompatible: better in vitro systems will provide better data to mathematical models. On the other hand increasingly sophisticated in vitro experiments collect increasingly numerous, complex, and challenging data to integrate: Mathematical models, such as systems biology models are much needed here.IVIVE can be split in two steps: (1) dealing with pharmacokinetics (PK) and (2) dealing with pharmacodynamics (PD). Basically, PK describes quantitatively the fate of molecules in the body; PD focuses on their effects (therapeutic or toxic) at the biological target(s) level. It is classical to differentiate PK from PD, but they form a continuum and there may be feedback one on each other.[2]".
- In_vitro_to_in_vivo_extrapolation wikiPageID "42810674".
- In_vitro_to_in_vivo_extrapolation wikiPageLength "6448".
- In_vitro_to_in_vivo_extrapolation wikiPageOutDegree "17".
- In_vitro_to_in_vivo_extrapolation wikiPageRevisionID "654886033".
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink Alternatives_to_animal_testing.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink Category:Alternatives_to_animal_testing.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink Category:Latin_biological_phrases.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink Human-on-a-chip.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink In_vitro.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink In_vivo.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink Organ-on-a-chip.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink PBPK.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink Pharmacodynamics.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink Pharmacokinetics.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink Physiologically_based_pharmacokinetic_modelling.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink Systems_biology.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLink Toxicology.
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLinkText "From ''in vitro'' to ''in vivo''".
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLinkText "In vitro to in vivo extrapolation".
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLinkText "extrapolation from ''in vitro'' to ''in vivo''".
- In_vitro_to_in_vivo_extrapolation wikiPageWikiLinkText "in vitro to in vivo extrapolation".
- In_vitro_to_in_vivo_extrapolation hasPhotoCollection In_vitro_to_in_vivo_extrapolation.
- In_vitro_to_in_vivo_extrapolation subject Category:Alternatives_to_animal_testing.
- In_vitro_to_in_vivo_extrapolation subject Category:Latin_biological_phrases.
- In_vitro_to_in_vivo_extrapolation comment "In vitro to in vivo extrapolation refers to the qualitative or quantitative transposition of experimental results or observations made in vitro to predicts phenomena in vivo, on full living organisms.The problem of transposing in vitro results is particularly acute in areas such as toxicology where animal experiments are being increasingly replaced by alternative tests.Results obtained from in vitro experiments cannot usually be transposed as is to predict the reaction of an entire organism in vivo. ".
- In_vitro_to_in_vivo_extrapolation label "In vitro to in vivo extrapolation".
- In_vitro_to_in_vivo_extrapolation sameAs m.010pd5j4.
- In_vitro_to_in_vivo_extrapolation sameAs Q17050441.
- In_vitro_to_in_vivo_extrapolation sameAs Q17050441.
- In_vitro_to_in_vivo_extrapolation wasDerivedFrom In_vitro_to_in_vivo_extrapolation?oldid=654886033.
- In_vitro_to_in_vivo_extrapolation isPrimaryTopicOf In_vitro_to_in_vivo_extrapolation.