Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/HMG-CoA_synthase> ?p ?o }
- HMG-CoA_synthase abstract "In molecular biology, HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which Acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). It is the second reaction in the mevalonate-dependent isoprenoid biosynthesis pathway. HMG-CoA is an intermediate in both cholesterol synthesis and ketogenesis. This reaction is over-activated in patients with diabetes mellitus type 1 if left untreated, due to prolonged insulin deficiency and the exhaustion of substrates for gluconeogenesis and the TCA cycle, notably oxaloacetate. This results in shunting of excess acetyl-CoA into the ketone synthesis pathway via HMG-CoA, leading to the development of diabetic ketoacidosis.".
- HMG-CoA_synthase arm "p".
- HMG-CoA_synthase band "13".
- HMG-CoA_synthase band "14".
- HMG-CoA_synthase chromosome "1".
- HMG-CoA_synthase chromosome "5".
- HMG-CoA_synthase ecNumber "2.3.3.10".
- HMG-CoA_synthase entrezgene "3157".
- HMG-CoA_synthase entrezgene "3158".
- HMG-CoA_synthase hgncid "5007".
- HMG-CoA_synthase hgncid "5008".
- HMG-CoA_synthase locusSupplementaryData "-p12".
- HMG-CoA_synthase locusSupplementaryData "-p13".
- HMG-CoA_synthase omim "142940".
- HMG-CoA_synthase omim "600234".
- HMG-CoA_synthase refseq "NM_002130".
- HMG-CoA_synthase refseq "NM_005518".
- HMG-CoA_synthase symbol "HMGCS".
- HMG-CoA_synthase symbol "HMGCS1".
- HMG-CoA_synthase symbol "HMGCS2".
- HMG-CoA_synthase symbol "HMG_CoA_synt_C".
- HMG-CoA_synthase symbol "HMG_CoA_synt_N".
- HMG-CoA_synthase thumbnail PDB_1txt_EBI.jpg?width=300.
- HMG-CoA_synthase uniprot "P54868".
- HMG-CoA_synthase uniprot "Q01581".
- HMG-CoA_synthase wikiPageID "10940718".
- HMG-CoA_synthase wikiPageLength "6836".
- HMG-CoA_synthase wikiPageOutDegree "56".
- HMG-CoA_synthase wikiPageRevisionID "660282908".
- HMG-CoA_synthase wikiPageWikiLink 3-hydroxy-3-methylglutaryl-CoA.
- HMG-CoA_synthase wikiPageWikiLink Acetoacetyl-CoA.
- HMG-CoA_synthase wikiPageWikiLink Acetyl-CoA.
- HMG-CoA_synthase wikiPageWikiLink Acetylation.
- HMG-CoA_synthase wikiPageWikiLink Archaea.
- HMG-CoA_synthase wikiPageWikiLink Bacteria.
- HMG-CoA_synthase wikiPageWikiLink Biosynthesis.
- HMG-CoA_synthase wikiPageWikiLink Catalysis.
- HMG-CoA_synthase wikiPageWikiLink Catalytic.
- HMG-CoA_synthase wikiPageWikiLink Category:EC_2.3.3.
- HMG-CoA_synthase wikiPageWikiLink Category:Protein_families.
- HMG-CoA_synthase wikiPageWikiLink Cholesterol.
- HMG-CoA_synthase wikiPageWikiLink Cholesterol_synthesis.
- HMG-CoA_synthase wikiPageWikiLink Citric_acid_cycle.
- HMG-CoA_synthase wikiPageWikiLink Coenzyme_A.
- HMG-CoA_synthase wikiPageWikiLink Cysteine.
- HMG-CoA_synthase wikiPageWikiLink Cytosol.
- HMG-CoA_synthase wikiPageWikiLink Cytosolic.
- HMG-CoA_synthase wikiPageWikiLink Diabetes_mellitus_type_1.
- HMG-CoA_synthase wikiPageWikiLink Diabetic_ketoacidosis.
- HMG-CoA_synthase wikiPageWikiLink Dietary_cholesterol.
- HMG-CoA_synthase wikiPageWikiLink Enzyme.
- HMG-CoA_synthase wikiPageWikiLink Eukaryote.
- HMG-CoA_synthase wikiPageWikiLink Eukaryotes.
- HMG-CoA_synthase wikiPageWikiLink Fungus.
- HMG-CoA_synthase wikiPageWikiLink Gene.
- HMG-CoA_synthase wikiPageWikiLink Gluconeogenesis.
- HMG-CoA_synthase wikiPageWikiLink Gram-positive.
- HMG-CoA_synthase wikiPageWikiLink Gram-positive_bacteria.
- HMG-CoA_synthase wikiPageWikiLink HMG-CoA.
- HMG-CoA_synthase wikiPageWikiLink Insect.
- HMG-CoA_synthase wikiPageWikiLink Insects.
- HMG-CoA_synthase wikiPageWikiLink Insulin.
- HMG-CoA_synthase wikiPageWikiLink Isoprenoid.
- HMG-CoA_synthase wikiPageWikiLink Isozyme.
- HMG-CoA_synthase wikiPageWikiLink Isozymes.
- HMG-CoA_synthase wikiPageWikiLink Ketogenesis.
- HMG-CoA_synthase wikiPageWikiLink Ketone_bodies.
- HMG-CoA_synthase wikiPageWikiLink LDL_receptor.
- HMG-CoA_synthase wikiPageWikiLink Low_density_lipoprotein_receptor.
- HMG-CoA_synthase wikiPageWikiLink MRNA.
- HMG-CoA_synthase wikiPageWikiLink Messenger_RNA.
- HMG-CoA_synthase wikiPageWikiLink Mevalonate.
- HMG-CoA_synthase wikiPageWikiLink Mevalonate_pathway.
- HMG-CoA_synthase wikiPageWikiLink Mevalonic_acid.
- HMG-CoA_synthase wikiPageWikiLink Mitochondrial.
- HMG-CoA_synthase wikiPageWikiLink Mitochondrion.
- HMG-CoA_synthase wikiPageWikiLink Nucleophile.
- HMG-CoA_synthase wikiPageWikiLink Nucleophilic_attack.
- HMG-CoA_synthase wikiPageWikiLink Oxaloacetate.
- HMG-CoA_synthase wikiPageWikiLink Oxaloacetic_acid.
- HMG-CoA_synthase wikiPageWikiLink Pathogen.
- HMG-CoA_synthase wikiPageWikiLink Plant.
- HMG-CoA_synthase wikiPageWikiLink Plants.
- HMG-CoA_synthase wikiPageWikiLink Redox.
- HMG-CoA_synthase wikiPageWikiLink Substrate_(biochemistry).
- HMG-CoA_synthase wikiPageWikiLink Substrate_(chemistry).
- HMG-CoA_synthase wikiPageWikiLink TCA_cycle.
- HMG-CoA_synthase wikiPageWikiLink Terpenoid.
- HMG-CoA_synthase wikiPageWikiLink Thioester.
- HMG-CoA_synthase wikiPageWikiLink Transcription_(genetics).
- HMG-CoA_synthase wikiPageWikiLink Vertebrate.
- HMG-CoA_synthase wikiPageWikiLink Vertebrates.
- HMG-CoA_synthase wikiPageWikiLink File:HMG-CoA_synthase.svg.
- HMG-CoA_synthase wikiPageWikiLink File:Ketogenesis.svg.
- HMG-CoA_synthase wikiPageWikiLink File:Mevalonate_pathway.png.
- HMG-CoA_synthase wikiPageWikiLinkText "HMG-CoA synthase".
- HMG-CoA_synthase altsymbols "HMGCS".
- HMG-CoA_synthase arm "p".
- HMG-CoA_synthase band "13".
- HMG-CoA_synthase band "14".