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- Genotype-first_approach abstract "The genotype-first approach is a type of strategy used in genetic epidemiological studies to associate specific genotypes to apparent clinical phenotypes of a complex disease or trait. As opposed to “phenotype-first”, the traditional strategy that have been guiding genome-wide association studies (GWAS) so far, this approach characterizes individuals first by a statistically common genotype based on molecular tests prior to clinical phenotypic classification. This method of grouping leads to patient evaluations based on a shared genetic etiology for the observed phenotypes, regardless of their suspected diagnosis. Thus, this approach can prevent initial phenotypic bias and allow for identification of genes that pose a significant contribution to the disease etiology.This approach is unaffected by phenotypic heterogeneity, incomplete penetrance and levels of expressivity. Therefore, it is useful in complex diseases that also overlap, such as autism spectrum disorder and intellectual disability, enabling the diseases to be distinguished, and specific subtypes of the disease based on the genomic content to be determined.Currently, the genotype-first approach is used primarily for research objectives. However, the implications from these studies can have valuable clinical applications, including improved diagnosis, counselling, and support groups for individuals with the same genetic etiology.".
- Genotype-first_approach wikiPageID "45497515".
- Genotype-first_approach wikiPageLength "11975".
- Genotype-first_approach wikiPageOutDegree "32".
- Genotype-first_approach wikiPageRevisionID "680972819".
- Genotype-first_approach wikiPageWikiLink Autism_spectrum.
- Genotype-first_approach wikiPageWikiLink Autism_spectrum_disorder.
- Genotype-first_approach wikiPageWikiLink Category:Cytogenetics.
- Genotype-first_approach wikiPageWikiLink Category:Genetics.
- Genotype-first_approach wikiPageWikiLink Category:Human_genetics.
- Genotype-first_approach wikiPageWikiLink Chromosome_banding.
- Genotype-first_approach wikiPageWikiLink Cytogenetic.
- Genotype-first_approach wikiPageWikiLink Cytogenetics.
- Genotype-first_approach wikiPageWikiLink Developmental_disability.
- Genotype-first_approach wikiPageWikiLink Down_syndrome.
- Genotype-first_approach wikiPageWikiLink Etiology_(medicine).
- Genotype-first_approach wikiPageWikiLink Exome_sequencing.
- Genotype-first_approach wikiPageWikiLink File:Lim_et_al._2014.jpg.
- Genotype-first_approach wikiPageWikiLink Fluorescence_in_situ_hybridization.
- Genotype-first_approach wikiPageWikiLink Gene.
- Genotype-first_approach wikiPageWikiLink Genetic_disorder.
- Genotype-first_approach wikiPageWikiLink Genome-wide_association_studies.
- Genotype-first_approach wikiPageWikiLink Genome-wide_association_study.
- Genotype-first_approach wikiPageWikiLink Genomic.
- Genotype-first_approach wikiPageWikiLink Genomics.
- Genotype-first_approach wikiPageWikiLink Genotype.
- Genotype-first_approach wikiPageWikiLink Intellectual_disability.
- Genotype-first_approach wikiPageWikiLink Karyotype.
- Genotype-first_approach wikiPageWikiLink Locus_(genetics).
- Genotype-first_approach wikiPageWikiLink Mendelian_inheritance.
- Genotype-first_approach wikiPageWikiLink Microarray.
- Genotype-first_approach wikiPageWikiLink Mutation.
- Genotype-first_approach wikiPageWikiLink Penetrance.
- Genotype-first_approach wikiPageWikiLink Phenotype.
- Genotype-first_approach wikiPageWikiLink Pleiotropic.
- Genotype-first_approach wikiPageWikiLink Pleiotropy.
- Genotype-first_approach wikiPageWikiLink Sanger_sequencing.
- Genotype-first_approach wikiPageWikiLink Trisomy_21.
- Genotype-first_approach wikiPageWikiLink Whole-genome_sequencing.
- Genotype-first_approach wikiPageWikiLink Whole_genome_sequencing.
- Genotype-first_approach wikiPageWikiLink File:Genotype-first_approach.tif.
- Genotype-first_approach wikiPageWikiLinkText "genotype-first approach".
- Genotype-first_approach wikiPageWikiLinkText "genotype-first".
- Genotype-first_approach hasPhotoCollection Genotype-first_approach.
- Genotype-first_approach wikiPageUsesTemplate Template:Reflist.
- Genotype-first_approach subject Category:Cytogenetics.
- Genotype-first_approach subject Category:Genetics.
- Genotype-first_approach subject Category:Human_genetics.
- Genotype-first_approach hypernym Strategy.
- Genotype-first_approach type VideoGame.
- Genotype-first_approach comment "The genotype-first approach is a type of strategy used in genetic epidemiological studies to associate specific genotypes to apparent clinical phenotypes of a complex disease or trait. As opposed to “phenotype-first”, the traditional strategy that have been guiding genome-wide association studies (GWAS) so far, this approach characterizes individuals first by a statistically common genotype based on molecular tests prior to clinical phenotypic classification.".
- Genotype-first_approach label "Genotype-first approach".
- Genotype-first_approach sameAs m.012wsc3v.
- Genotype-first_approach wasDerivedFrom Genotype-first_approach?oldid=680972819.
- Genotype-first_approach isPrimaryTopicOf Genotype-first_approach.