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- Efferocytosis abstract "In cell biology, efferocytosis (from efferre, Latin for 'to take to the grave', 'to bury') is the process by which dying/dead cells (e.g. apoptotic or necrotic) are removed by phagocytic cells. It can be regarded as the 'burying of dead cells'.During efferocytosis, the cell membrane of phagocytic cells engulfs the apoptotic cell, forming a large fluid-filled vesicle containing the dead cell. This ingested vesicle is called an efferosome (in analogy to the term phagosome). This process is similar to macropinocytosis. For apoptosis, the effect of efferocytosis is that dead cells are removed before their membrane integrity is breached and their contents leak into the surrounding tissue. This prevents exposure of tissue to toxic enzymes, oxidants and other intracellular components such as proteases and caspases.Efferocytosis can be performed not only by 'professional' phagocytic cells such as macrophages or dendritic cells, but also by many other cell types including epithelial cells and fibroblasts. To distinguish them from living cells, apoptotic cells carry specific 'eat me' signals, such as the presence of phosphatidyl serine (resulting from phospholipid flip-flop) or calreticulin on the outer leaflet of the cell membrane.Efferocytosis triggers specific downstream intracellular signal transduction pathways, for example resulting in anti-inflammatory, anti-protease and growth-promoting effects. Conversely, impaired efferocytosis has been linked to autoimmune disease and tissue damage. Efferocytosis results in production by the ingesting cell of mediators such as hepatocyte- and vascular endothelial growth factor, which are thought to promote replacement of the dead cells.Defective efferocytosis has been demonstrated in such diseases as cystic fibrosis and bronchiectasis, COPD, asthma and idiopathic pulmonary fibrosis, rheumatoid arthritis, systemic lupus erythematosus, glomerulonephritis and atherosclerosis.".
- Efferocytosis wikiPageID "22328498".
- Efferocytosis wikiPageLength "3329".
- Efferocytosis wikiPageOutDegree "35".
- Efferocytosis wikiPageRevisionID "661017675".
- Efferocytosis wikiPageWikiLink Apoptosis.
- Efferocytosis wikiPageWikiLink Asthma.
- Efferocytosis wikiPageWikiLink Atherosclerosis.
- Efferocytosis wikiPageWikiLink Autoimmune_disease.
- Efferocytosis wikiPageWikiLink Bronchiectasis.
- Efferocytosis wikiPageWikiLink Calreticulin.
- Efferocytosis wikiPageWikiLink Caspase.
- Efferocytosis wikiPageWikiLink Category:Cellular_processes.
- Efferocytosis wikiPageWikiLink Cell_(biology).
- Efferocytosis wikiPageWikiLink Cell_biology.
- Efferocytosis wikiPageWikiLink Cell_membrane.
- Efferocytosis wikiPageWikiLink Chronic_obstructive_pulmonary_disease.
- Efferocytosis wikiPageWikiLink Cystic_fibrosis.
- Efferocytosis wikiPageWikiLink Dendritic_cell.
- Efferocytosis wikiPageWikiLink Epithelial_cell.
- Efferocytosis wikiPageWikiLink Epithelium.
- Efferocytosis wikiPageWikiLink Fibroblast.
- Efferocytosis wikiPageWikiLink Flippase.
- Efferocytosis wikiPageWikiLink Glomerulonephritis.
- Efferocytosis wikiPageWikiLink Hepatocyte_growth_factor.
- Efferocytosis wikiPageWikiLink Idiopathic_pulmonary_fibrosis.
- Efferocytosis wikiPageWikiLink Inflammation.
- Efferocytosis wikiPageWikiLink Intracellular.
- Efferocytosis wikiPageWikiLink Latin.
- Efferocytosis wikiPageWikiLink Macrophage.
- Efferocytosis wikiPageWikiLink Macrophages.
- Efferocytosis wikiPageWikiLink Macropinocytosis.
- Efferocytosis wikiPageWikiLink Necrosis.
- Efferocytosis wikiPageWikiLink Oxidant.
- Efferocytosis wikiPageWikiLink Oxidizing_agent.
- Efferocytosis wikiPageWikiLink Phagocytosis.
- Efferocytosis wikiPageWikiLink Phagosome.
- Efferocytosis wikiPageWikiLink Phosphatidyl_serine.
- Efferocytosis wikiPageWikiLink Phosphatidylserine.
- Efferocytosis wikiPageWikiLink Phospholipid_flip-flop.
- Efferocytosis wikiPageWikiLink Pinocytosis.
- Efferocytosis wikiPageWikiLink Protease.
- Efferocytosis wikiPageWikiLink Rheumatoid_arthritis.
- Efferocytosis wikiPageWikiLink Signal_transduction.
- Efferocytosis wikiPageWikiLink Systemic_lupus_erythematosus.
- Efferocytosis wikiPageWikiLink Vascular_endothelial_growth_factor.
- Efferocytosis wikiPageWikiLinkText "Efferocytosis".
- Efferocytosis wikiPageWikiLinkText "efferocytosis".
- Efferocytosis hasPhotoCollection Efferocytosis.
- Efferocytosis wikiPageUsesTemplate Template:Membrane_transport.
- Efferocytosis wikiPageUsesTemplate Template:Reflist.
- Efferocytosis subject Category:Cellular_processes.
- Efferocytosis hypernym Process.
- Efferocytosis type Article.
- Efferocytosis type Election.
- Efferocytosis type Article.
- Efferocytosis type Process.
- Efferocytosis comment "In cell biology, efferocytosis (from efferre, Latin for 'to take to the grave', 'to bury') is the process by which dying/dead cells (e.g. apoptotic or necrotic) are removed by phagocytic cells. It can be regarded as the 'burying of dead cells'.During efferocytosis, the cell membrane of phagocytic cells engulfs the apoptotic cell, forming a large fluid-filled vesicle containing the dead cell. This ingested vesicle is called an efferosome (in analogy to the term phagosome).".
- Efferocytosis label "Efferocytosis".
- Efferocytosis sameAs m.05s_sbx.
- Efferocytosis sameAs Q5347407.
- Efferocytosis sameAs Q5347407.
- Efferocytosis sameAs 胞葬作用.
- Efferocytosis wasDerivedFrom Efferocytosis?oldid=661017675.
- Efferocytosis isPrimaryTopicOf Efferocytosis.