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- Edmund_Kornfeld abstract "Edmund Carl Kornfeld (24 February 1919 – 22 June 2012) was an American organic chemist who devoted his life to the research of new drugs. His leading discovery, with the help of a team, was a unique antibiotic later known as Vancomycin. Kornfeld received his PhD in chemistry from Harvard in 1944 and subsequently joined Eli Lilly Company, in Indianapolis, US. It was there where most of his discoveries took place. In 1953, Kornfeld and his team isolated an unknown microbe, Streptomyces orientalis, which was found in soil samples from Borneo. This microbe produced a unique compound which had the remarkable property of killing all staphylococci bacteria, including the penicillin-resistant strains. The drug’s ability to inhibit straphylococci was stable during early assays, suggesting that it might be clinically useful for a long period.One of the most difficult tasks that Kornfeld and his team faced was purifying the new compound. The purification method employed during that time utilised picric acid - a potentially explosive chemical; because of this an alternate process was developed. However, this new method yielded material with a purity of only 82% and when solubilized, produced a brown liquid aptly termed “Mississippi mud”. However, due to the need for an alternative to penicillin in resistant bacterial infections, the initial preparations were considered safe enough for use in humans.The first human trial was in 1950. The drug was given to a patient that had developed a severe infection on his foot after surgery which was unresposnsive to multiple antibiotics. The surgical staff recommended amputation or the usage of the new antibiotic. His answer was ‘ Anything that might save my foot’. Due to the spread of the bacteria, a high dosage the antibiotic of 05865 was recommended, 100 mg every eight hours, over five days. After the first day, the heat was decreasing, his white cell count was dropping and the exudate of his wound was less. During the next seven days, the staphylococci disappeared from the wound, and his foot was free from any sign of infection. Two months later he left the hospital with an intact foot. The new antibiotic was named Vancomycin, from the term "vanquish" and was FDA approved in 1958.".
- Edmund_Kornfeld birthDate "1919-02-24".
- Edmund_Kornfeld birthYear "1919".
- Edmund_Kornfeld deathDate "2012-06-22".
- Edmund_Kornfeld deathYear "2012".
- Edmund_Kornfeld thumbnail Edmund_Kornfeld.png?width=300.
- Edmund_Kornfeld wikiPageExternalLink 1.
- Edmund_Kornfeld wikiPageExternalLink fg.cgi?page=gr&GRid=92929749.
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- Edmund_Kornfeld wikiPageExternalLink womed_jul-aug11.pdf.
- Edmund_Kornfeld wikiPageID "33863610".
- Edmund_Kornfeld wikiPageLength "4761".
- Edmund_Kornfeld wikiPageOutDegree "12".
- Edmund_Kornfeld wikiPageRevisionID "607098693".
- Edmund_Kornfeld wikiPageWikiLink Borneo.
- Edmund_Kornfeld wikiPageWikiLink Category:1919_births.
- Edmund_Kornfeld wikiPageWikiLink Category:2012_deaths.
- Edmund_Kornfeld wikiPageWikiLink Category:American_chemists.
- Edmund_Kornfeld wikiPageWikiLink Category:Harvard_University_alumni.
- Edmund_Kornfeld wikiPageWikiLink Category:Organic_chemists.
- Edmund_Kornfeld wikiPageWikiLink Eli_Lilly_and_Company.
- Edmund_Kornfeld wikiPageWikiLink Picric_acid.
- Edmund_Kornfeld wikiPageWikiLink Streptomyces_orientalis.
- Edmund_Kornfeld wikiPageWikiLink Vancomycin.
- Edmund_Kornfeld wikiPageWikiLink File:Edmund_Kornfeld.png.
- Edmund_Kornfeld wikiPageWikiLinkText "Edmund Kornfeld".
- Edmund_Kornfeld dateOfBirth "1919-02-24".
- Edmund_Kornfeld dateOfDeath "2012-06-22".
- Edmund_Kornfeld hasPhotoCollection Edmund_Kornfeld.
- Edmund_Kornfeld name "Kornfeld, Edmund".
- Edmund_Kornfeld placeOfDeath "Noblesville, Hamilton County, Indiana, USA".
- Edmund_Kornfeld shortDescription "American chemist".
- Edmund_Kornfeld wikiPageUsesTemplate Template:Persondata.
- Edmund_Kornfeld wikiPageUsesTemplate Template:Reflist.
- Edmund_Kornfeld description "American chemist".
- Edmund_Kornfeld description "American chemist".
- Edmund_Kornfeld subject Category:1919_births.
- Edmund_Kornfeld subject Category:2012_deaths.
- Edmund_Kornfeld subject Category:American_chemists.
- Edmund_Kornfeld subject Category:Harvard_University_alumni.
- Edmund_Kornfeld subject Category:Organic_chemists.
- Edmund_Kornfeld hypernym Chemist.
- Edmund_Kornfeld type Agent.
- Edmund_Kornfeld type Person.
- Edmund_Kornfeld type Scientist.
- Edmund_Kornfeld type Scientist.
- Edmund_Kornfeld type Person.
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- Edmund_Kornfeld comment "Edmund Carl Kornfeld (24 February 1919 – 22 June 2012) was an American organic chemist who devoted his life to the research of new drugs. His leading discovery, with the help of a team, was a unique antibiotic later known as Vancomycin. Kornfeld received his PhD in chemistry from Harvard in 1944 and subsequently joined Eli Lilly Company, in Indianapolis, US. It was there where most of his discoveries took place.".
- Edmund_Kornfeld label "Edmund Kornfeld".
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- Edmund_Kornfeld sameAs Q5339619.
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- Edmund_Kornfeld wasDerivedFrom Edmund_Kornfeld?oldid=607098693.
- Edmund_Kornfeld depiction Edmund_Kornfeld.png.
- Edmund_Kornfeld givenName "Edmund".
- Edmund_Kornfeld isPrimaryTopicOf Edmund_Kornfeld.
- Edmund_Kornfeld name "Edmund Kornfeld".
- Edmund_Kornfeld name "Kornfeld, Edmund".
- Edmund_Kornfeld surname "Kornfeld".