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- Cortodoxone abstract "11-Deoxycortisol, also known as cortodoxone (INN, USAN, BAN), as well as 17-hydroxy-11-deoxycorticosterone, 17α,21-dihydroxyprogesterone, and cortexolone, is a glucocorticoid steroid hormone that can be oxygenated to cortisol (hydrocortisone). It was first synthesized by Tadeusz Reichstein, and has also been referred to as Reichstein's Substance.On April 5, 1952, biochemist Durey Peterson and microbiologist Herbert Murray at Upjohn published the first report of a breakthrough fermentation process for the microbial 11α-oxygenation of steroids (e.g. progesterone) in a single step by common molds of the order Mucorales.11α-oxygenation of cortodoxone produces 11α-hydrocortisone, which can be chemically oxidized to cortisone, or converted by further chemical steps to cortisol.Subsequent fermentation processes for the microbial 11β-oxygenation of steroids in a single step were developed that could convert cortodoxone directly to cortisol.Cortodoxone functions as a glucocorticoid, though is less potent than cortisol. It can be synthesized from 17-hydroxyprogesterone. In 11β-hydroxylase deficiency, cortodoxone levels increase dramatically, causing hypertension (as opposed to 21α-hydroxylase deficiency, in which patients have low blood pressure from a lack of mineralocorticoids).Cortodoxone can also be converted to androstenedione. This could explain, at least in part, the marked increase in androstenedione levels in 11β-hydroxylase deficiency.".
- Cortodoxone iupacName "(8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one".
- Cortodoxone thumbnail Cortodoxone.png?width=300.
- Cortodoxone wikiPageID "22312974".
- Cortodoxone wikiPageLength "4847".
- Cortodoxone wikiPageOutDegree "22".
- Cortodoxone wikiPageRevisionID "676612268".
- Cortodoxone wikiPageWikiLink 11-Deoxycorticosterone.
- Cortodoxone wikiPageWikiLink 17-Hydroxyprogesterone.
- Cortodoxone wikiPageWikiLink 17-hydroxyprogesterone.
- Cortodoxone wikiPageWikiLink Androstenedione.
- Cortodoxone wikiPageWikiLink Biochemist.
- Cortodoxone wikiPageWikiLink British_Approved_Name.
- Cortodoxone wikiPageWikiLink Category:Glucocorticoids.
- Cortodoxone wikiPageWikiLink Category:Mineralocorticoids.
- Cortodoxone wikiPageWikiLink Category:Steroids.
- Cortodoxone wikiPageWikiLink Cortisol.
- Cortodoxone wikiPageWikiLink Cortisone.
- Cortodoxone wikiPageWikiLink Glucocorticoid.
- Cortodoxone wikiPageWikiLink Hypotension.
- Cortodoxone wikiPageWikiLink Industrial_fermentation.
- Cortodoxone wikiPageWikiLink International_Nonproprietary_Name.
- Cortodoxone wikiPageWikiLink Microbiologist.
- Cortodoxone wikiPageWikiLink Mold.
- Cortodoxone wikiPageWikiLink Mucorales.
- Cortodoxone wikiPageWikiLink Progesterone.
- Cortodoxone wikiPageWikiLink Steroid_hormone.
- Cortodoxone wikiPageWikiLink Tadeusz_Reichstein.
- Cortodoxone wikiPageWikiLink United_States_Adopted_Name.
- Cortodoxone wikiPageWikiLink Upjohn.
- Cortodoxone wikiPageWikiLinkText "Compound S".
- Cortodoxone wikiPageWikiLinkText "Cortodoxone".
- Cortodoxone wikiPageWikiLinkText "Reichstein's Substance S".
- Cortodoxone wikiPageWikiLinkText "cortodoxone".
- Cortodoxone hasPhotoCollection Cortodoxone.
- Cortodoxone imagealt "Cortodoxone molecule".
- Cortodoxone imagefile "Cortodoxone-3D-balls.png".
- Cortodoxone imagefile "Cortodoxone.png".
- Cortodoxone imagesize "220".
- Cortodoxone iupacname "-17".
- Cortodoxone othernames "11".
- Cortodoxone verifiedfields "changed".
- Cortodoxone verifiedrevid "396318614".
- Cortodoxone watchedfields "changed".
- Cortodoxone wikiPageUsesTemplate Template:Biochemistry-stub.
- Cortodoxone wikiPageUsesTemplate Template:Chembox.
- Cortodoxone wikiPageUsesTemplate Template:Glucocorticoidics.
- Cortodoxone wikiPageUsesTemplate Template:Mineralocorticoidics.
- Cortodoxone wikiPageUsesTemplate Template:Reflist.
- Cortodoxone wikiPageUsesTemplate Template:Steroid-stub.
- Cortodoxone wikiPageUsesTemplate Template:Steroid_hormones.
- Cortodoxone subject Category:Glucocorticoids.
- Cortodoxone subject Category:Mineralocorticoids.
- Cortodoxone subject Category:Steroids.
- Cortodoxone hypernym Hormone.
- Cortodoxone type ChemicalCompound.
- Cortodoxone type ChemicalSubstance.
- Cortodoxone type Lipid.
- Cortodoxone type Protein.
- Cortodoxone type Chemical.
- Cortodoxone type Lipid.
- Cortodoxone type Steroid.
- Cortodoxone type Terpene.
- Cortodoxone type ChemicalObject.
- Cortodoxone type Thing.
- Cortodoxone type Q11173.
- Cortodoxone comment "11-Deoxycortisol, also known as cortodoxone (INN, USAN, BAN), as well as 17-hydroxy-11-deoxycorticosterone, 17α,21-dihydroxyprogesterone, and cortexolone, is a glucocorticoid steroid hormone that can be oxygenated to cortisol (hydrocortisone).".
- Cortodoxone label "Cortodoxone".
- Cortodoxone sameAs کورتودوکسون.
- Cortodoxone sameAs 11-Désoxycortisol.
- Cortodoxone sameAs m.05s_f3x.
- Cortodoxone sameAs 11-деоксикортизол.
- Cortodoxone sameAs Kortodokson.
- Cortodoxone sameAs Kortodokson.
- Cortodoxone sameAs Q2064915.
- Cortodoxone sameAs Q2064915.
- Cortodoxone wasDerivedFrom Cortodoxone?oldid=676612268.
- Cortodoxone depiction Cortodoxone.png.
- Cortodoxone isPrimaryTopicOf Cortodoxone.