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- testis_antigens abstract "Cancer/testis (CT) antigens are a group of proteins united by their importance in development and in cancer immunotherapy. In general, expression of these proteins is restricted to male germ cells in the adult animal. However, in cancer these developmental antigens are often re-expressed and can serve as a locus of immune activation. Thus, they are often classified as tumor antigens. The expression of CT in various malignancies is heterogeneous and often correlates with tumor progression. CT antigens have been described in melanoma, liver cancer, lung cancer, bladder cancer, and pediatric tumors such as neuroblastoma. Gametogenesis offers an important role for many of these antigens in the differentiation, migration, and cell division of primordial germ cells, spermatagonia spermatocytes and spermatids.At least 70 familes, totaling more than 140 members have been identified.The Ludwig Institute for Cancer Research (LICR) maintains the "CTDatabase." This database is an authoritative list of known CT antigens. It also serves as a repository into which new candidates can be entered.Important CT antigens in cancer therapy include MAGE-A1, MAGE-A3, MAGE-A4, NY-ESO-1, PRAME and SSX2.".
- testis_antigens wikiPageID "47052678".
- testis_antigens wikiPageLength "2691".
- testis_antigens wikiPageOutDegree "14".
- testis_antigens wikiPageRevisionID "668661557".
- testis_antigens wikiPageWikiLink Bladder_cancer.
- testis_antigens wikiPageWikiLink Cancer_immunotherapy.
- testis_antigens wikiPageWikiLink Category:Tumor.
- testis_antigens wikiPageWikiLink Gametogenesis.
- testis_antigens wikiPageWikiLink Germ_cell.
- testis_antigens wikiPageWikiLink Germ_cells.
- testis_antigens wikiPageWikiLink Liver_cancer.
- testis_antigens wikiPageWikiLink Lung_cancer.
- testis_antigens wikiPageWikiLink Melanoma.
- testis_antigens wikiPageWikiLink Neuroblastoma.
- testis_antigens wikiPageWikiLink Protein.
- testis_antigens wikiPageWikiLink Proteins.
- testis_antigens wikiPageWikiLink Spermatagonia.
- testis_antigens wikiPageWikiLink Spermatid.
- testis_antigens wikiPageWikiLink Spermatids.
- testis_antigens wikiPageWikiLink Spermatocyte.
- testis_antigens wikiPageWikiLink Spermatocytes.
- testis_antigens wikiPageWikiLink Tumor_antigens.
- testis_antigens wikiPageWikiLinkText "Cancer/testis antigens".
- testis_antigens wikiPageWikiLinkText "MAGE-A1".
- testis_antigens hasPhotoCollection testis_antigens.
- testis_antigens wikiPageUsesTemplate Template:Orphan.
- testis_antigens wikiPageUsesTemplate Template:Reflist.
- testis_antigens subject Category:Tumor.
- testis_antigens hypernym Group.
- testis_antigens type Band.
- testis_antigens comment "Cancer/testis (CT) antigens are a group of proteins united by their importance in development and in cancer immunotherapy. In general, expression of these proteins is restricted to male germ cells in the adult animal. However, in cancer these developmental antigens are often re-expressed and can serve as a locus of immune activation. Thus, they are often classified as tumor antigens. The expression of CT in various malignancies is heterogeneous and often correlates with tumor progression.".
- testis_antigens label "Cancer/testis antigens".
- testis_antigens wasDerivedFrom testis_antigens?oldid=668661557.
- testis_antigens isPrimaryTopicOf testis_antigens.