Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Brilacidin> ?p ?o }
- Brilacidin abstract "Brilacidin (formerly PMX-30063) an investigational new drug (IND), is a polymer-based antibiotic currently in human clinical trials and represents a completely new class of antibiotics called host defense protein mimetics, host defense peptide mimetics, or HDP-mimetics, which are non-peptide synthetic small-molecules modeled after host defense peptides (HDP). HDP, also called antimicrobial peptides, some of which are defensins, are part of the innate immune response and are common to most higher forms of life. As Brilacidin is modelled after a defensin, it is also called a defensin mimetic.Brilacidin is thus an antibiotic that works by disrupting bacterial cell membranes, mimicking defensins that play a role in innate immunity. Several mimics of antimicrobial peptides have been researched, both peptides and non peptides, but none have overcome difficulties to reach the market. Brilacidin, a non-peptide chemical mimic, is an arylamide foldamer designed to replicate the amphiphilic properties of antimicrobial peptides while solving the problems encountered by peptide-based antimicrobials.Brilacidin, a broad-spectrum antibiotic, has potent Gram positive activity and Gram negative coverage, and is highly effective in treating the 'superbug' methicillin-resistant Staphylococcus aureus (MRSA). Brilacidin has low cytotoxicity against mammalian cells selectively targeting bacteria, directly and rapidly disrupting their membranes, resulting in the bacteria's death. Due to this unique mechanism of action (mimicking the host's natural immune response, proven to be successful in fighting off infections over millions of years of evolution), bacterial antibiotic resistance is less likely to develop.There has not been a new drug approval from a new class of antibiotics since 1987. While six antibiotics have been approved over the last year, they are all adaptations of existing antibiotic classes. None of the recently approved novel antibiotics represent entirely new classes. Novel antibiotics are crucial as antibiotic resistance is a global health risk. The World Health Organization, warning of a "post-antibiotic era" has stated that antimicrobial resistance (AMR) is a "problem so serious that it threatens the achievements of modern medicine".".
- Brilacidin atcPrefix "none".
- Brilacidin casNumber "1224095-98-0".
- Brilacidin iupacName "N,N'-bis[3-{[5-(carbamimidoylamino)pentanoyl]amino}-2-[(3R)-pyrrolidin-3-yloxy]-5-(trifluoromethyl)phenyl]pyrimidine-4,6-dicarboxamide".
- Brilacidin pubchem "25023695".
- Brilacidin thumbnail Brilacidin-.png?width=300.
- Brilacidin wikiPageExternalLink Welcome.
- Brilacidin wikiPageID "40308088".
- Brilacidin wikiPageLength "29759".
- Brilacidin wikiPageOutDegree "63".
- Brilacidin wikiPageRevisionID "682303966".
- Brilacidin wikiPageWikiLink ABSSSI.
- Brilacidin wikiPageWikiLink Acinetobacter_baumannii.
- Brilacidin wikiPageWikiLink Amphiphile.
- Brilacidin wikiPageWikiLink Amphiphilic.
- Brilacidin wikiPageWikiLink Antibiotic.
- Brilacidin wikiPageWikiLink Antibiotic_resistance.
- Brilacidin wikiPageWikiLink Antibiotics.
- Brilacidin wikiPageWikiLink Antimicrobial.
- Brilacidin wikiPageWikiLink Antimicrobial_peptides.
- Brilacidin wikiPageWikiLink Antimicrobial_resistance.
- Brilacidin wikiPageWikiLink Antimicrobials.
- Brilacidin wikiPageWikiLink Blind_experiment.
- Brilacidin wikiPageWikiLink Broad-spectrum_antibiotic.
- Brilacidin wikiPageWikiLink Candida_(fungus).
- Brilacidin wikiPageWikiLink Category:Antibiotics.
- Brilacidin wikiPageWikiLink Chemoradiation.
- Brilacidin wikiPageWikiLink Chemoradiotherapy.
- Brilacidin wikiPageWikiLink Chronic_wound.
- Brilacidin wikiPageWikiLink Clinical_trial.
- Brilacidin wikiPageWikiLink Daptomycin.
- Brilacidin wikiPageWikiLink Defensin.
- Brilacidin wikiPageWikiLink Defensins.
- Brilacidin wikiPageWikiLink Diabetic_foot_ulcers.
- Brilacidin wikiPageWikiLink Double_blind.
- Brilacidin wikiPageWikiLink Escherichia_coli.
- Brilacidin wikiPageWikiLink FDA.
- Brilacidin wikiPageWikiLink Foldamer.
- Brilacidin wikiPageWikiLink Food_and_Drug_Administration.
- Brilacidin wikiPageWikiLink Food_and_Drug_Administration_Safety_and_Innovation_Act.
- Brilacidin wikiPageWikiLink Gram-negative_bacteria.
- Brilacidin wikiPageWikiLink Gram-positive_bacteria.
- Brilacidin wikiPageWikiLink Gram_negative.
- Brilacidin wikiPageWikiLink Gram_positive.
- Brilacidin wikiPageWikiLink Head_and_neck_cancer.
- Brilacidin wikiPageWikiLink Host_defense_peptides.
- Brilacidin wikiPageWikiLink In_Vitro.
- Brilacidin wikiPageWikiLink Innate_immune_system.
- Brilacidin wikiPageWikiLink Innate_immunity.
- Brilacidin wikiPageWikiLink Intent-to-treat.
- Brilacidin wikiPageWikiLink Intention-to-treat_analysis.
- Brilacidin wikiPageWikiLink Intravenous_therapy.
- Brilacidin wikiPageWikiLink Investigational_New_Drug.
- Brilacidin wikiPageWikiLink Investigational_new_drug.
- Brilacidin wikiPageWikiLink Klebsiella_pneumoniae.
- Brilacidin wikiPageWikiLink MRSA.
- Brilacidin wikiPageWikiLink Methicillin-resistant_Staphylococcus_aureus.
- Brilacidin wikiPageWikiLink Mole_(unit).
- Brilacidin wikiPageWikiLink Mucositis.
- Brilacidin wikiPageWikiLink Peptide.
- Brilacidin wikiPageWikiLink Peptides.
- Brilacidin wikiPageWikiLink Placebo.
- Brilacidin wikiPageWikiLink Principal_investigator.
- Brilacidin wikiPageWikiLink Pseudomonas_aeruginosa.
- Brilacidin wikiPageWikiLink Skin_and_skin_structure_infection.
- Brilacidin wikiPageWikiLink Stalking_horse.
- Brilacidin wikiPageWikiLink Staphylococcus_Aureus.
- Brilacidin wikiPageWikiLink Staphylococcus_aureus.
- Brilacidin wikiPageWikiLink Super_Bug.
- Brilacidin wikiPageWikiLink Super_bug_(bacteria).
- Brilacidin wikiPageWikiLink Superbugs.
- Brilacidin wikiPageWikiLinkText "Brilacidin".
- Brilacidin atcPrefix "none".
- Brilacidin c "40".
- Brilacidin casNumber "1224095".
- Brilacidin chembl "2219413".
- Brilacidin chemspiderid "28651526".
- Brilacidin f "6".
- Brilacidin h "50".
- Brilacidin hasPhotoCollection Brilacidin.
- Brilacidin inchi "1".
- Brilacidin inchikey "QPDYBCZNGUJZDK-DNQXCXABBB".
- Brilacidin iupacName "N,N'-bis[3-{[5-pentanoyl]amino}-2-[-pyrrolidin-3-yloxy]-5-phenyl]pyrimidine-4,6-dicarboxamide".
- Brilacidin molecularWeight "936.9".
- Brilacidin n "14".
- Brilacidin o "6".
- Brilacidin pubchem "25023695".
- Brilacidin smiles "C1CNC[C@@H]1OC2=CNCCCCCNCN".
- Brilacidin stdinchi "1".
- Brilacidin stdinchikey "QPDYBCZNGUJZDK-DNQXCXABSA-N".
- Brilacidin tradename "None as of July 2012".
- Brilacidin width "300".
- Brilacidin wikiPageUsesTemplate Template:Antibiotics.
- Brilacidin wikiPageUsesTemplate Template:Cite_web.
- Brilacidin wikiPageUsesTemplate Template:Drugbox.
- Brilacidin wikiPageUsesTemplate Template:Medref.
- Brilacidin wikiPageUsesTemplate Template:Reflist.
- Brilacidin subject Category:Antibiotics.
- Brilacidin type ChemicalSubstance.
- Brilacidin type Drug.