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- Barbiturate_overdose abstract "A barbiturate overdose results when a person takes excessive doses of barbiturates. Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness, shallow breathing, and staggering. In severe cases, coma and death can result. The lethal dosage of barbiturates varies greatly with tolerance and from one individual to another.Barbiturate overdose with other CNS (central nervous system) depressants, such as alcohol, opiates or benzodiazepines, is even more dangerous due to additive CNS and respiratory depressant effects. In the case of benzodiazepines, barbiturates also increase the binding affinity of the benzodiazepine binding sites thus leading to an exaggerated effect of benzodiazepines. This makes the predicting the effect of combinations difficult and the same dose of the same drugs will not always produce the same degree of sedation and respiratory depression as the previous experience.Benzodiazepines increase the frequency of chloride channel opening while barbiturates increase the duration that the chloride pore remains open. If a normal pore opened once every 30 seconds to pass one chloride ion, a benzodiazepine may cause it to open once every ten seconds while a barbiturate may cause it to remain open until three ions have passed through. Separately, both of these increase the effect of the pore threefold, but together, the channel would allow three ions to pass every 10 seconds. This would exponentially increase the effect of the pore ninefold, greater than the sum of the two drugs effects.The treatment of barbiturate abuse or overdose is generally supportive. The amount of support required depends on the person's symptoms. If the patient is drowsy but awake and can swallow and breathe without difficulty, the treatment can be as simple as monitoring the patient closely. If the patient is not breathing, it may involve mechanical ventilation until the drug has worn off.Supportive treatment often includes the following: Activated charcoal may be given via nasogastric tube. Intravenous administration of saline, naloxone, thiamine, and/or glucose. NaHCO3 to alkalize the urine to increase rate of excretion. Intubation and bemegride, or a hand-breather where these are not available until the patient can breathe under their own power. Observation in the Emergency Department for a number of hours or admission to the hospital for several days of observation if symptoms are severe. Advise the patient about drug misuse or refer for psychiatric consult.In famous cases, Marilyn Monroe, Dalida, Judy Garland, Jimi Hendrix, and also Edie Sedgwick died from a barbiturate overdose.".
- Barbiturate_overdose icd10 "F13.0,T42.3".
- Barbiturate_overdose icd9 "969".
- Barbiturate_overdose wikiPageID "26983645".
- Barbiturate_overdose wikiPageLength "4517".
- Barbiturate_overdose wikiPageOutDegree "23".
- Barbiturate_overdose wikiPageRevisionID "673445745".
- Barbiturate_overdose wikiPageWikiLink Analeptic.
- Barbiturate_overdose wikiPageWikiLink Barbiturate.
- Barbiturate_overdose wikiPageWikiLink Bemegride.
- Barbiturate_overdose wikiPageWikiLink Benzodiazepine.
- Barbiturate_overdose wikiPageWikiLink Benzodiazepines.
- Barbiturate_overdose wikiPageWikiLink Binding_site.
- Barbiturate_overdose wikiPageWikiLink Category:Barbiturates.
- Barbiturate_overdose wikiPageWikiLink Category:Poisoning_by_drugs,_medicaments_and_biological_substances.
- Barbiturate_overdose wikiPageWikiLink Chloride_channel.
- Barbiturate_overdose wikiPageWikiLink Dalida.
- Barbiturate_overdose wikiPageWikiLink Drug_tolerance.
- Barbiturate_overdose wikiPageWikiLink Edie_Sedgwick.
- Barbiturate_overdose wikiPageWikiLink Ethanol.
- Barbiturate_overdose wikiPageWikiLink Excretion.
- Barbiturate_overdose wikiPageWikiLink Glucose.
- Barbiturate_overdose wikiPageWikiLink Jimi_Hendrix.
- Barbiturate_overdose wikiPageWikiLink Judy_Garland.
- Barbiturate_overdose wikiPageWikiLink Marilyn_Monroe.
- Barbiturate_overdose wikiPageWikiLink Naloxone.
- Barbiturate_overdose wikiPageWikiLink Opiate.
- Barbiturate_overdose wikiPageWikiLink Opiates.
- Barbiturate_overdose wikiPageWikiLink Sodium_bicarbonate.
- Barbiturate_overdose wikiPageWikiLink Thiamine.
- Barbiturate_overdose wikiPageWikiLink Urine.
- Barbiturate_overdose wikiPageWikiLinkText "Barbiturate Poisoning".
- Barbiturate_overdose wikiPageWikiLinkText "Barbiturate overdose".
- Barbiturate_overdose wikiPageWikiLinkText "Butalbital overdose".
- Barbiturate_overdose wikiPageWikiLinkText "acute barbiturate intoxication".
- Barbiturate_overdose wikiPageWikiLinkText "barbiturate overdose".
- Barbiturate_overdose wikiPageWikiLinkText "barbiturate poisoning".
- Barbiturate_overdose wikiPageWikiLinkText "overdose of barbiturates".
- Barbiturate_overdose wikiPageWikiLinkText "overdose".
- Barbiturate_overdose wikiPageWikiLinkText "overdosing on barbiturates".
- Barbiturate_overdose emedicinesubj "article".
- Barbiturate_overdose emedicinetopic "813155".
- Barbiturate_overdose hasPhotoCollection Barbiturate_overdose.
- Barbiturate_overdose icd "969".
- Barbiturate_overdose icd "F13.0, T42.3".
- Barbiturate_overdose name "Barbiturate overdose".
- Barbiturate_overdose wikiPageUsesTemplate Template:Infobox_disease.
- Barbiturate_overdose wikiPageUsesTemplate Template:Poisoning_and_toxicity.
- Barbiturate_overdose wikiPageUsesTemplate Template:Psychoactive_substance_use.
- Barbiturate_overdose wikiPageUsesTemplate Template:Reflist.
- Barbiturate_overdose subject Category:Barbiturates.
- Barbiturate_overdose subject Category:Poisoning_by_drugs,_medicaments_and_biological_substances.
- Barbiturate_overdose type Disease.
- Barbiturate_overdose type Anticonvulsant.
- Barbiturate_overdose type Imide.
- Barbiturate_overdose type Thing.
- Barbiturate_overdose type Q12136.
- Barbiturate_overdose comment "A barbiturate overdose results when a person takes excessive doses of barbiturates. Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness, shallow breathing, and staggering. In severe cases, coma and death can result.".
- Barbiturate_overdose label "Barbiturate overdose".
- Barbiturate_overdose sameAs Intossicazione_da_barbiturici.
- Barbiturate_overdose sameAs バルビツール酸系過量服薬.
- Barbiturate_overdose sameAs m.0bwj2gf.
- Barbiturate_overdose sameAs Q1184752.
- Barbiturate_overdose sameAs Q1184752.
- Barbiturate_overdose wasDerivedFrom Barbiturate_overdose?oldid=673445745.
- Barbiturate_overdose isPrimaryTopicOf Barbiturate_overdose.
- Barbiturate_overdose name "Barbiturate overdose".