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- Atrasentan abstract "Atrasentan is an experimental drug that is being studied for the treatment of various types of cancer, including non-small cell lung cancer. It is also being investigated as a therapy for diabetic kidney disease.Atrasentan failed a phase 3 trial for prostate cancer in patients unresponsive to hormone therapy. A second trial confirmed this finding.It is an endothelin receptor antagonist selective for subtype A (ETA). While other drugs of this type (sitaxentan, ambrisentan) exploit the vasoconstrictive properties of endothelin and are mainly used for the treatment of pulmonary arterial hypertension, atrasentan blocks endothelin induced cell proliferation.In April 2014, de Zeeuw et al. showed that 0.5 mg and 1.25 mg of atrasentan reduced urinary albumin by 35 and 38% respectively with modest side effects. Patients also had decreased home blood pressures (but no change in office readings) decrease total cholesterol and LDL. Patients in the 1.25 mg dose group had increased weight gain which was presumably due to increased edema and had to withdraw from the study more than the placebo or 0.5 mg dose group. Reductions in proteinuria have been associated with beneficial patient outcomes in diabetic kidney disease with other interventions but is not an accepted end-point by the FDA.The recently initiated SONAR trial will determine if atrasentan reduces kidney failure in diabetic kidney disease.".
- Atrasentan atcPrefix "none".
- Atrasentan casNumber "173937-91-2".
- Atrasentan fdaUniiCode "V6D7VK2215".
- Atrasentan iupacName "(2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid".
- Atrasentan pubchem "159594".
- Atrasentan thumbnail Atrasentan.svg?width=300.
- Atrasentan wikiPageID "14416367".
- Atrasentan wikiPageLength "6952".
- Atrasentan wikiPageOutDegree "13".
- Atrasentan wikiPageRevisionID "679804699".
- Atrasentan wikiPageWikiLink Ambrisentan.
- Atrasentan wikiPageWikiLink Cancer.
- Atrasentan wikiPageWikiLink Category:Benzodioxoles.
- Atrasentan wikiPageWikiLink Category:Carboxylic_acids.
- Atrasentan wikiPageWikiLink Category:Endothelin_receptor_antagonists.
- Atrasentan wikiPageWikiLink Category:Experimental_cancer_drugs.
- Atrasentan wikiPageWikiLink Cell_growth.
- Atrasentan wikiPageWikiLink Cell_proliferation.
- Atrasentan wikiPageWikiLink Endothelin_receptor_antagonist.
- Atrasentan wikiPageWikiLink Endothelin_receptor_type_A.
- Atrasentan wikiPageWikiLink Lung_cancer.
- Atrasentan wikiPageWikiLink Pulmonary_arterial_hypertension.
- Atrasentan wikiPageWikiLink Pulmonary_hypertension.
- Atrasentan wikiPageWikiLink Sitaxentan.
- Atrasentan wikiPageWikiLink Vasoconstriction.
- Atrasentan wikiPageWikiLink Vasoconstrictive.
- Atrasentan wikiPageWikiLinkText "Atrasentan".
- Atrasentan wikiPageWikiLinkText "atrasentan".
- Atrasentan atcPrefix "none".
- Atrasentan c "29".
- Atrasentan casNumber "173937".
- Atrasentan chembl "9194".
- Atrasentan chemspiderid "140321".
- Atrasentan h "38".
- Atrasentan hasPhotoCollection Atrasentan.
- Atrasentan inchi "1".
- Atrasentan inchikey "MOTJMGVDPWRKOC-QPVYNBJUBX".
- Atrasentan iupacName "-4".
- Atrasentan molecularWeight "510.621".
- Atrasentan n "2".
- Atrasentan o "6".
- Atrasentan pubchem "159594".
- Atrasentan smiles "O=C[C@H]4[C@H]NC[C@@H]4c2ccc3OCOc3c2".
- Atrasentan stdinchi "1".
- Atrasentan stdinchikey "MOTJMGVDPWRKOC-QPVYNBJUSA-N".
- Atrasentan unii "V6D7VK2215".
- Atrasentan verifiedfields "changed".
- Atrasentan verifiedrevid "458631282".
- Atrasentan watchedfields "changed".
- Atrasentan wikiPageUsesTemplate Template:Chemotherapeutic_agents.
- Atrasentan wikiPageUsesTemplate Template:Drugbox.
- Atrasentan wikiPageUsesTemplate Template:Fact.
- Atrasentan wikiPageUsesTemplate Template:Peptidergics.
- Atrasentan wikiPageUsesTemplate Template:Reflist.
- Atrasentan subject Category:Benzodioxoles.
- Atrasentan subject Category:Carboxylic_acids.
- Atrasentan subject Category:Endothelin_receptor_antagonists.
- Atrasentan subject Category:Experimental_cancer_drugs.
- Atrasentan hypernym Drug.
- Atrasentan type Article.
- Atrasentan type ChemicalSubstance.
- Atrasentan type Drug.
- Atrasentan type Antagonist.
- Atrasentan type Article.
- Atrasentan type Chemical.
- Atrasentan type Drug.
- Atrasentan type Specialty.
- Atrasentan type ChemicalObject.
- Atrasentan type Thing.
- Atrasentan type Q8386.
- Atrasentan comment "Atrasentan is an experimental drug that is being studied for the treatment of various types of cancer, including non-small cell lung cancer. It is also being investigated as a therapy for diabetic kidney disease.Atrasentan failed a phase 3 trial for prostate cancer in patients unresponsive to hormone therapy. A second trial confirmed this finding.It is an endothelin receptor antagonist selective for subtype A (ETA).".
- Atrasentan label "Atrasentan".
- Atrasentan sameAs Atrasentan.
- Atrasentan sameAs m.03d2vrl.
- Atrasentan sameAs Atrasentan.
- Atrasentan sameAs Atrasentan.
- Atrasentan sameAs Q125083.
- Atrasentan sameAs Q125083.
- Atrasentan wasDerivedFrom Atrasentan?oldid=679804699.
- Atrasentan depiction Atrasentan.svg.
- Atrasentan isPrimaryTopicOf Atrasentan.