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- Antisense_RNA abstract "Antisense RNA (asRNA) is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell. Some authors have used the term micRNA (mRNA-interfering complementary RNA) to refer to these RNAs but it is not widely used.Antisense RNA may be introduced into a cell to inhibit translation of a complementary mRNA by base pairing to it and physically obstructing the translation machinery. This effect is therefore stoichiometric. An example of naturally occurring mRNA antisense mechanism is the hok/sok system of the E. coli R1 plasmid. Antisense RNA has long been thought of as a promising technique for disease therapy; the only such case to have reached the market is the drug fomivirsen. One commentator has characterized antisense RNA as one of "dozens of technologies that are gorgeous in concept, but exasperating in [commercialization]". Generally, antisense RNA still lack effective design, biological activity, and efficient route of administration.The effects of antisense RNA are related with the effects of RNA interference (RNAi). The RNAi process, found only in eukaryotes, is initiated by double-stranded RNA fragments, which may be created by the expression of an anti-sense RNA followed by the base-pairing of the anti-sense strand to the target transcript. Double-stranded RNA may be created by other mechanisms (including secondary RNA structure). The double-stranded RNA is cleaved into small fragements by DICER, and then a single strand of the fragment is incorporated into the RNA-induced silencing complex (RISC) so that the RISC may bind to and degrade the complementary mRNA target. Some genetically engineered transgenic plants that express antisense RNA do activate the RNAi pathway. This processes resulted in differing magnitudes of gene silencing induced by the expression of antisense RNA. Well-known examples include the Flavr Savr tomato and two cultivars of ringspot-resistant papaya.Transcription of longer cis-antisense transcripts is a common phenomenon in the mammalian transcriptome. Although the function of some cases have been described, such as the Zeb2/Sip1 antisense RNA, no general function has been elucidated. In the case of Zeb2/Sip1, the antisense noncoding RNA is opposite the 5' splice site of an intron in the 5'UTR of the Zeb2 mRNA. Expression of the antisense ncRNA prevents splicing of an intron that contains a ribosome entry site necessary for efficient expression of the Zeb2 protein. Transcription of long antisense ncRNAs is often concordant with the associated protein-coding gene, but more detailed studies have revealed that the relative expression patterns of the mRNA and antisense ncRNA are complex.".
- Antisense_RNA wikiPageID "1158788".
- Antisense_RNA wikiPageLength "7764".
- Antisense_RNA wikiPageOutDegree "26".
- Antisense_RNA wikiPageRevisionID "678162829".
- Antisense_RNA wikiPageWikiLink Base_pair.
- Antisense_RNA wikiPageWikiLink Category:Antisense_RNA.
- Antisense_RNA wikiPageWikiLink Category:Non-coding_RNA.
- Antisense_RNA wikiPageWikiLink Cell_(biology).
- Antisense_RNA wikiPageWikiLink Cis-natural_antisense_transcript.
- Antisense_RNA wikiPageWikiLink Complementarity_(molecular_biology).
- Antisense_RNA wikiPageWikiLink Cultivar.
- Antisense_RNA wikiPageWikiLink Escherichia_coli.
- Antisense_RNA wikiPageWikiLink Flavr_Savr.
- Antisense_RNA wikiPageWikiLink Fomivirsen.
- Antisense_RNA wikiPageWikiLink Genetic_engineering.
- Antisense_RNA wikiPageWikiLink sok_system.
- Antisense_RNA wikiPageWikiLink Intron.
- Antisense_RNA wikiPageWikiLink Long_non-coding_RNA.
- Antisense_RNA wikiPageWikiLink Long_noncoding_RNA.
- Antisense_RNA wikiPageWikiLink Messenger_RNA.
- Antisense_RNA wikiPageWikiLink Papaya.
- Antisense_RNA wikiPageWikiLink Papaya_ringspot_virus.
- Antisense_RNA wikiPageWikiLink RNA.
- Antisense_RNA wikiPageWikiLink RNA-induced_silencing_complex.
- Antisense_RNA wikiPageWikiLink RNA_interference.
- Antisense_RNA wikiPageWikiLink Route_of_administration.
- Antisense_RNA wikiPageWikiLink Stoichiometry.
- Antisense_RNA wikiPageWikiLink Tomato.
- Antisense_RNA wikiPageWikiLink Transcription_(genetics).
- Antisense_RNA wikiPageWikiLink Transgene.
- Antisense_RNA wikiPageWikiLink Translation_(biology).
- Antisense_RNA wikiPageWikiLink Translation_(genetics).
- Antisense_RNA wikiPageWikiLinkText "Antisense RNA".
- Antisense_RNA wikiPageWikiLinkText "Antisense".
- Antisense_RNA wikiPageWikiLinkText "RNA antisense transcripts".
- Antisense_RNA wikiPageWikiLinkText "antisense RNA".
- Antisense_RNA wikiPageWikiLinkText "antisense binding".
- Antisense_RNA wikiPageWikiLinkText "antisense pairing".
- Antisense_RNA wikiPageWikiLinkText "antisense regulator".
- Antisense_RNA wikiPageWikiLinkText "antisense transcription".
- Antisense_RNA wikiPageWikiLinkText "antisense transcripts".
- Antisense_RNA wikiPageWikiLinkText "antisense".
- Antisense_RNA wikiPageWikiLinkText "negative sense, single-stranded RNA".
- Antisense_RNA hasPhotoCollection Antisense_RNA.
- Antisense_RNA wikiPageUsesTemplate Template:Mergefrom.
- Antisense_RNA wikiPageUsesTemplate Template:Natural_antisense_transcripts.
- Antisense_RNA wikiPageUsesTemplate Template:Nucleic_acids.
- Antisense_RNA wikiPageUsesTemplate Template:Reflist.
- Antisense_RNA subject Category:Antisense_RNA.
- Antisense_RNA subject Category:Non-coding_RNA.
- Antisense_RNA hypernym RNA.
- Antisense_RNA type Protein.
- Antisense_RNA comment "Antisense RNA (asRNA) is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell. Some authors have used the term micRNA (mRNA-interfering complementary RNA) to refer to these RNAs but it is not widely used.Antisense RNA may be introduced into a cell to inhibit translation of a complementary mRNA by base pairing to it and physically obstructing the translation machinery. This effect is therefore stoichiometric.".
- Antisense_RNA label "Antisense RNA".
- Antisense_RNA sameAs Antisense_RNA.
- Antisense_RNA sameAs Antisense_teknik.
- Antisense_RNA sameAs Antisense-RNA.
- Antisense_RNA sameAs Antisentido.
- Antisense_RNA sameAs ADN_antisens.
- Antisense_RNA sameAs Antisense-gen.
- Antisense_RNA sameAs m.04c5sy.
- Antisense_RNA sameAs ARN_antisens.
- Antisense_RNA sameAs Антисмысловые_РНК.
- Antisense_RNA sameAs Protismiselna_RNK.
- Antisense_RNA sameAs Антисенсові_РНК.
- Antisense_RNA sameAs Q423832.
- Antisense_RNA sameAs Q423832.
- Antisense_RNA wasDerivedFrom Antisense_RNA?oldid=678162829.
- Antisense_RNA isPrimaryTopicOf Antisense_RNA.