Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/ActoBiotics> ?p ?o }
Showing triples 1 to 38 of
38
with 100 triples per page.
- ActoBiotics abstract "ActoBiotics (a registered trademark) consist of food-grade bacteria (Lactococcus lactis), genetically engineered to synthesize and secrete therapeutic proteins and peptides in situ. ActoBiotics are delivered to patients via oral administration instead of injection, and specifically target receptors and cells localized in gastrointestinal (GI) tissues. The selective and targeted delivery to GI receptors, may increase efficacy combined with a more favorable side effect profile.ActoBiotics are developed by ActoGeniX, a biopharmaceutical company based in Ghent, Belgium. ActoBiotics are formulated as oral capsules. A scientific article by L. Steidler stated: "ActoBiotics represent a novel class of orally administered and locally acting biopharmaceuticals." ActoBiotics display significant competitive advantages over first and second generation pharma products (conventional chemical drugs and biologicals respectively).ActoGeniX’s lead product, AG013, is an ActoBiotic for the treatment of oral mucositis. In May 2009, the U.S. Food and Drug Administration (FDA) approved ActoGeniX’s IND application, allowing the company to initiate a phase 1B clinical trial with AG013 in cancer patients at risk of developing oral mucositis. This clinical study has been recently finalized. AG013 was proven to be safe and well tolerated. Analysis of initial efficacy showed a 35% reduction of the percentage of days with ulcerative oral mucositis in the AG013-treated patients versus the placebo-treated patients. Furthermore, close to 30% of the patients treated with AG013 were full responders while all placebo-treated patients developed ulcerative oral mucositis.A press release by the University of Leuven stated: "In April 2012, Prof. Chantal Mathieu and her team at the University Hospital of Leuven announced a potential major breakthrough in the treatment of Type 1 diabetes using the drug. The ActoBiotic can stably reinstate normal glucose levels in Type 1 diabetic mice. This strategy was without side effects and can now be further developed for human application." The Journal of Clinical Investigation published the results of the study.".
- ActoBiotics wikiPageExternalLink www.actogenix.com.
- ActoBiotics wikiPageID "36726792".
- ActoBiotics wikiPageLength "5514".
- ActoBiotics wikiPageOutDegree "14".
- ActoBiotics wikiPageRevisionID "536057250".
- ActoBiotics wikiPageWikiLink ActoGeniX.
- ActoBiotics wikiPageWikiLink Category:Genetically_modified_organisms.
- ActoBiotics wikiPageWikiLink Celiac_disease.
- ActoBiotics wikiPageWikiLink Coeliac_disease.
- ActoBiotics wikiPageWikiLink Crohns_disease.
- ActoBiotics wikiPageWikiLink Diabetes_mellitus_type_1.
- ActoBiotics wikiPageWikiLink Diabetes_mellitus_type_2.
- ActoBiotics wikiPageWikiLink Food_and_Drug_Administration.
- ActoBiotics wikiPageWikiLink Lactococcus_lactis.
- ActoBiotics wikiPageWikiLink Mucositis.
- ActoBiotics wikiPageWikiLink Oral_mucositis.
- ActoBiotics wikiPageWikiLink Peptide.
- ActoBiotics wikiPageWikiLink Peptides.
- ActoBiotics wikiPageWikiLink Protein.
- ActoBiotics wikiPageWikiLink Proteins.
- ActoBiotics wikiPageWikiLink Type_1_diabetes.
- ActoBiotics wikiPageWikiLink Type_2_diabetes.
- ActoBiotics wikiPageWikiLink Ulcerative_colitis.
- ActoBiotics wikiPageWikiLinkText "ActoBiotics".
- ActoBiotics hasPhotoCollection ActoBiotics.
- ActoBiotics wikiPageUsesTemplate Template:Reflist.
- ActoBiotics subject Category:Genetically_modified_organisms.
- ActoBiotics type Controversy.
- ActoBiotics type Organism.
- ActoBiotics type Organism.
- ActoBiotics comment "ActoBiotics (a registered trademark) consist of food-grade bacteria (Lactococcus lactis), genetically engineered to synthesize and secrete therapeutic proteins and peptides in situ. ActoBiotics are delivered to patients via oral administration instead of injection, and specifically target receptors and cells localized in gastrointestinal (GI) tissues.".
- ActoBiotics label "ActoBiotics".
- ActoBiotics sameAs m.0l8nrd_.
- ActoBiotics sameAs Q4677645.
- ActoBiotics sameAs Q4677645.
- ActoBiotics wasDerivedFrom ActoBiotics?oldid=536057250.
- ActoBiotics isPrimaryTopicOf ActoBiotics.