Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/ABCB5> ?p ?o }
Showing triples 1 to 63 of
63
with 100 triples per page.
- ABCB5 abstract "ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.More recently, the ABCB5 molecule has been shown to be functionally relevant to carcinogenesis, demonstrated in colorectal cancer where it was shown to act as a mediator of 5-FU patient chemoresistance, and had a further direct role in tumorigenesis shown by shRNA-mediated colorectal cancer cell-line ABCB5 knockdowns that impeded tumorigenesis in human-to-mouse xenografts. These data revealed multiple roles for ABCB5 in cancer progression and chemoresistance, making it an attractive target for combined therapy. ABCB5 was similarly demonstrated in melanoma to be functionally important to multi-drug chemotherapy resistance, and tumor growth, controlling a proinflammatory signaling circuit utilizing TLR4, IL-1β, IL8 and CXCR1 signaling involving reciprocal paracrine interactions between the melanoma stem cell and tumor bulk population (in a rheostat manner termed "cancer stem cell rheostasis" by the authors). ABCB5 was shown to maintain the slow-cycling melanoma stem cells using this cytokine signaling loop, which became more differentiated upon ABCB5 interference (e.g. WFDC1 melanocyte differentiation marker increased, cancer cells were faster growing in vitro, tumors were more pigmented), or CXCR1 blockade (slow-cycling ABCB5+ cells entered the cell-cycle).In normal physiology ABCB5 was shown to be a functional marker for adult limbal stem cells of the cornea; ABCB5+ cells could regrow a human cornea on a mouse with limbal stem cell deficiency (LSCD - a blindness disease of the corneal limbus) while ABCB5- cells could not, indicating a therapeutic potential for treating some types of blindness. ABCB5 was further shown to be anti-apoptotic in these adult stem cells.".
- ABCB5 entrezgene "340273".
- ABCB5 wikiPageExternalLink b_viewarticle.php?3158333.
- ABCB5 wikiPageExternalLink 19725928.
- ABCB5 wikiPageID "8884213".
- ABCB5 wikiPageLength "14664".
- ABCB5 wikiPageOutDegree "19".
- ABCB5 wikiPageRevisionID "678400086".
- ABCB5 wikiPageWikiLink 5-FU.
- ABCB5 wikiPageWikiLink ABC_transporter.
- ABCB5 wikiPageWikiLink ATP-binding_cassette_transporter.
- ABCB5 wikiPageWikiLink CXCR1.
- ABCB5 wikiPageWikiLink Category:Tumor_markers.
- ABCB5 wikiPageWikiLink Cornea.
- ABCB5 wikiPageWikiLink Corneal_limbus.
- ABCB5 wikiPageWikiLink Cytokine.
- ABCB5 wikiPageWikiLink FLT1.
- ABCB5 wikiPageWikiLink Fluorouracil.
- ABCB5 wikiPageWikiLink Gene.
- ABCB5 wikiPageWikiLink IL-1β.
- ABCB5 wikiPageWikiLink IL1B.
- ABCB5 wikiPageWikiLink Interleukin_8.
- ABCB5 wikiPageWikiLink Interleukin_8_receptor,_alpha.
- ABCB5 wikiPageWikiLink Melanoma.
- ABCB5 wikiPageWikiLink P-glycoprotein.
- ABCB5 wikiPageWikiLink Paracrine.
- ABCB5 wikiPageWikiLink Paracrine_signalling.
- ABCB5 wikiPageWikiLink Proceedings_of_the_National_Academy_of_Sciences_of_the_United_States_of_America.
- ABCB5 wikiPageWikiLink Protein.
- ABCB5 wikiPageWikiLink ShRNA.
- ABCB5 wikiPageWikiLink Small_hairpin_RNA.
- ABCB5 wikiPageWikiLink TLR4.
- ABCB5 wikiPageWikiLink VEGFR1.
- ABCB5 wikiPageWikiLink Xenograft.
- ABCB5 wikiPageWikiLink Xenotransplantation.
- ABCB5 wikiPageWikiLinkText "ABCB5".
- ABCB5 hasPhotoCollection ABCB5.
- ABCB5 wikiPageUsesTemplate Template:ABC_transporters.
- ABCB5 wikiPageUsesTemplate Template:Cite_journal.
- ABCB5 wikiPageUsesTemplate Template:Genetics-stub.
- ABCB5 wikiPageUsesTemplate Template:MeshName.
- ABCB5 wikiPageUsesTemplate Template:PBB.
- ABCB5 wikiPageUsesTemplate Template:Refbegin.
- ABCB5 wikiPageUsesTemplate Template:Refend.
- ABCB5 wikiPageUsesTemplate Template:Reflist.
- ABCB5 wikiPageUsesTemplate Template:UCSC_gene_details.
- ABCB5 wikiPageUsesTemplate Template:UCSC_genome_browser.
- ABCB5 subject Category:Tumor_markers.
- ABCB5 hypernym Protein.
- ABCB5 type Article.
- ABCB5 type Biomolecule.
- ABCB5 type Protein.
- ABCB5 type Article.
- ABCB5 type Thing.
- ABCB5 type Q206229.
- ABCB5 type Q8054.
- ABCB5 comment "ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma.".
- ABCB5 label "ABCB5".
- ABCB5 sameAs m.027n6s7.
- ABCB5 sameAs Q4650058.
- ABCB5 sameAs Q4650058.
- ABCB5 wasDerivedFrom ABCB5?oldid=678400086.
- ABCB5 isPrimaryTopicOf ABCB5.