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- Q9390597 subject Q6902168.
- Q9390597 subject Q8494146.
- Q9390597 abstract "The fertile eunuch syndrome is a cause of hypogonadotropic hypogonadism caused by a lutheinizing hormone deficiency. It is characterized by hypogonadism with spermatogenesis. Pasqualini and Bur published the first case of eunuchoidism with preserved spermatogenesis in 1950 in la Revista de la Asociación Médica Argentina.The hypoandrogenism with spermatogenesis syndrome included: (a) eunuchoidism, (b) testis with normal spermatogenesis and full volume, with mature spermatozoids in a high proportion of seminiferous tubes and undifferentiated and immature Leydig cells (c) full functional compensation through the administration of chorionic gonadotropin hormone, while hCG is administered (d) total urinary gonadotrophins within normal limits (e) this definition implies the normal activity of the pituitary and the absence of congenital malformations in general. In describing five other similar cases in 1953, Mc Cullagh & al coined the term fertile eunuch introducing it in the English literature. Unfortunately, this term is incorrect and should not be employed. Indeed, these patients are not really eunuchs. Moreover, as it will be explained later, they are not usually fertile if not treated.A first step in the understanding of the physiopathology of Pasqualini syndrome was the absence of Lutheinizing Hormone (LH) in plasma and urine of patients. The second breakthrough was the functional and genetic studies that validated the hypothesis of a functional deficit of LH in these men. Inactivating LH mutations will then also be described in some women. Different groups demonstrated in these cases a LH with varying degrees of immunological activity but biologically inactive in most of the patients, due to one or more inactivating mutations in the LHB gene. Finally, the full comprehension of Pasqualini syndrome allowed to reverse the hypoandrogenic phenotype and to restore fertility in these patients through the use of chorionic gonadotropin and the modern in-vitro fertility techniques".
- Q9390597 wikiPageWikiLink Q1165179.
- Q9390597 wikiPageWikiLink Q14864006.
- Q9390597 wikiPageWikiLink Q1516012.
- Q9390597 wikiPageWikiLink Q156871.
- Q9390597 wikiPageWikiLink Q1641332.
- Q9390597 wikiPageWikiLink Q164386.
- Q9390597 wikiPageWikiLink Q1703595.
- Q9390597 wikiPageWikiLink Q179399.
- Q9390597 wikiPageWikiLink Q200774.
- Q9390597 wikiPageWikiLink Q208360.
- Q9390597 wikiPageWikiLink Q277954.
- Q9390597 wikiPageWikiLink Q36961.
- Q9390597 wikiPageWikiLink Q409770.
- Q9390597 wikiPageWikiLink Q422812.
- Q9390597 wikiPageWikiLink Q5581325.
- Q9390597 wikiPageWikiLink Q62614.
- Q9390597 wikiPageWikiLink Q6902168.
- Q9390597 wikiPageWikiLink Q8494146.
- Q9390597 wikiPageWikiLink Q938107.
- Q9390597 comment "The fertile eunuch syndrome is a cause of hypogonadotropic hypogonadism caused by a lutheinizing hormone deficiency. It is characterized by hypogonadism with spermatogenesis.".
- Q9390597 label "Fertile eunuch syndrome".