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- Q907313 subject Q7071513.
- Q907313 subject Q7145095.
- Q907313 subject Q7162167.
- Q907313 subject Q8522216.
- Q907313 subject Q9581105.
- Q907313 abstract "Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.It was withdrawn from human use in the United States market in April 1994. The drug was previously available in the United Kingdom for use in humans under the brand name Modrenal for the treatment of Cushing's disease and for breast cancer. It was approved in the United States in 2008 for the treatment of Cushing's disease (hyperadrenocorticism) in dogs under the brand name Vetoryl. It was available by prescription in the UK under the Vetoryl brand name for some time before it was approved in the US. The drug is also used to treat the skin disorder Alopecia X in dogs.It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs. This prescription drug works by stopping the production of cortisol in the adrenal glands. In studies of the drug, the most common side effects were vomiting, lack of energy, diarrhea, and weight loss. Trilostane should not be given to a dog that:has kidney or liver disease;takes certain medications used to treat heart disease;is pregnant, nursing or intended for breeding The safety and effectiveness of trilostane were shown in several studies. Success was measured by improvements in both blood test results and physical symptoms (increased appetite and activity level, and decreased panting, thirst and urination).Only one other drug, Anipryl (veterinary brand name) selegiline, is FDA-approved to treat Cushing's disease in dogs, but only to treat uncomplicated, pituitary-dependent Cushing's. The only previous treatment for the disease was the use of Mitotane (brand name Lysodren) off-label.It has been used as a progesterone inhibitor.A number of compounding pharmacies in the US sell the product. Since the US approval of Vetoryl in December 2008, compounding pharmacies are no longer able to use a bulk drug product for compounding purposes, but must prepare the compounded drug from Vetoryl.It is a 3β-hydroxysteroid dehydrogenase inhibitor.".
- Q907313 atcPrefix "H02".
- Q907313 atcSuffix "CA01".
- Q907313 casNumber "13647-35-3".
- Q907313 chEBI "32260".
- Q907313 drugbank "DB01108".
- Q907313 fdaUniiCode "L0FPV48Q5R".
- Q907313 iupacName "(4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile".
- Q907313 pubchem "656583".
- Q907313 thumbnail Trilostane.svg?width=300.
- Q907313 wikiPageExternalLink SPC_183023.pdf.
- Q907313 wikiPageWikiLink Q219102.
- Q907313 wikiPageWikiLink Q229666.
- Q907313 wikiPageWikiLink Q26963.
- Q907313 wikiPageWikiLink Q402633.
- Q907313 wikiPageWikiLink Q417465.
- Q907313 wikiPageWikiLink Q42332.
- Q907313 wikiPageWikiLink Q7071513.
- Q907313 wikiPageWikiLink Q7145095.
- Q907313 wikiPageWikiLink Q7162167.
- Q907313 wikiPageWikiLink Q8522216.
- Q907313 wikiPageWikiLink Q9581105.
- Q907313 atcPrefix "H02".
- Q907313 atcSuffix "CA01".
- Q907313 casNumber "13647".
- Q907313 chebi "32260".
- Q907313 drugbank "DB01108".
- Q907313 iupacName "-317".
- Q907313 pubchem "656583".
- Q907313 unii "L0FPV48Q5R".
- Q907313 type ChemicalSubstance.
- Q907313 type Drug.
- Q907313 type ChemicalObject.
- Q907313 type Thing.
- Q907313 type Q8386.
- Q907313 comment "Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.It was withdrawn from human use in the United States market in April 1994. The drug was previously available in the United Kingdom for use in humans under the brand name Modrenal for the treatment of Cushing's disease and for breast cancer. It was approved in the United States in 2008 for the treatment of Cushing's disease (hyperadrenocorticism) in dogs under the brand name Vetoryl.".
- Q907313 label "Trilostane".
- Q907313 depiction Trilostane.svg.