Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q906704> ?p ?o }
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- Q906704 subject Q8802898.
- Q906704 abstract "Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. The protein helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. It also helps the sarcoplasmic reticulum store an extraordinarily high amount of calcium ions. Each molecule of calsequestrin can bind 18 to 50 Ca2+ ions. Sequence analysis has suggested that calcium is not bound in distinct pockets via EF-hand motifs, but rather via presentation of a charged protein surface. Two forms of calsequestrin have been identified. The cardiac form (Calsequestrin-2/CASQ2) is present in cardiac and slow skeletal muscle and the fast skeletal form (Calsequestrin-1/CASQ1) is found in fast skeletal muscle. The release of calsequestrin-bound calcium (through a calcium release channel) triggers muscle contraction. The active protein is not highly structured, more than 50% of it adopting a random coil conformation. When calcium binds there is a structural change whereby the alpha-helical content of the protein increases from 3 to 11%. Both forms of calsequestrin are phosphorylated by casein kinase 2, but the cardiac form is phosphorylated more rapidly and to a higher degree. Calsequestrin is also secreted in the gut where it deprives bacteria of calcium ions.".
- Q906704 arm "p".
- Q906704 arm "q".
- Q906704 band "13.3".
- Q906704 band "21".
- Q906704 chromosome "1".
- Q906704 entrezgene "844".
- Q906704 entrezgene "845".
- Q906704 hgncid "1512".
- Q906704 hgncid "1513".
- Q906704 locusSupplementaryData "-p11".
- Q906704 omim "114250".
- Q906704 omim "114251".
- Q906704 pdb "1A8Y".
- Q906704 refseq "NM_001231".
- Q906704 refseq "NM_001232".
- Q906704 symbol "CASQ".
- Q906704 symbol "CASQ1".
- Q906704 symbol "CASQ2".
- Q906704 symbol "Calsequestrin".
- Q906704 thumbnail Calsequestrin1.png?width=300.
- Q906704 uniprot "O14958".
- Q906704 uniprot "P31415".
- Q906704 wikiPageExternalLink NBK1289.
- Q906704 wikiPageWikiLink Q127006.
- Q906704 wikiPageWikiLink Q1649897.
- Q906704 wikiPageWikiLink Q2390792.
- Q906704 wikiPageWikiLink Q242736.
- Q906704 wikiPageWikiLink Q283399.
- Q906704 wikiPageWikiLink Q3511065.
- Q906704 wikiPageWikiLink Q487844.
- Q906704 wikiPageWikiLink Q5018802.
- Q906704 wikiPageWikiLink Q5048393.
- Q906704 wikiPageWikiLink Q79927.
- Q906704 wikiPageWikiLink Q8802898.
- Q906704 wikiPageWikiLink Q906704.
- Q906704 altsymbols "CASQ".
- Q906704 arm "p".
- Q906704 arm "q".
- Q906704 band "13.3".
- Q906704 band "21".
- Q906704 chromosome "1".
- Q906704 entrezgene "844".
- Q906704 entrezgene "845".
- Q906704 hgncid "1512".
- Q906704 hgncid "1513".
- Q906704 locussupplementarydata "-p11".
- Q906704 name "calsequestrin 1".
- Q906704 name "calsequestrin 2".
- Q906704 omim "114250".
- Q906704 omim "114251".
- Q906704 pdb "1".
- Q906704 refseq "NM_001231".
- Q906704 refseq "NM_001232".
- Q906704 symbol "CASQ1".
- Q906704 symbol "CASQ2".
- Q906704 symbol "Calsequestrin".
- Q906704 uniprot "O14958".
- Q906704 uniprot "P31415".
- Q906704 type Biomolecule.
- Q906704 type Protein.
- Q906704 type Thing.
- Q906704 type Q206229.
- Q906704 type Q8054.
- Q906704 comment "Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. The protein helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. It also helps the sarcoplasmic reticulum store an extraordinarily high amount of calcium ions. Each molecule of calsequestrin can bind 18 to 50 Ca2+ ions.".
- Q906704 label "Calsequestrin".
- Q906704 depiction Calsequestrin1.png.
- Q906704 name "calsequestrin 1 (fast-twitch, skeletal muscle)".
- Q906704 name "calsequestrin 2 (cardiac muscle)".