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- Q906570 subject Q7164711.
- Q906570 subject Q7216294.
- Q906570 subject Q9454631.
- Q906570 abstract "Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of the functional ribosome around the start codon and also provide regulatory mechanisms in translation initiation. Several initiation factors form a complex with the small 40S ribosomal subunit and Met-tRNAiMet called the 43S preinitation complex (PIC). Additional factors of the eIF4F complex (eIF4A, E, and G) recruit the 43S PIC to the five-prime cap structure of messenger RNA to promote ribosomal scanning along the mRNA to reach an AUG start codon. Recognition of the start codon by the Met-tRNAiMet promotes GTP hydrolysis (or gated phosphate release) by specific initiation factors and initiation factor release, resulting in the 60S ribosomal subunit recruitment to form the 80S ribosome. There exist many more eukaryotic initiation factors than prokaryotic initiation factors, reflecting the greater biological complexity of eukaryotic cells. Eukaryotic translation requires at least twelve eukaryotic initiation factors, described below.".
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- Q906570 wikiPageWikiLink Q7164711.
- Q906570 wikiPageWikiLink Q7216294.
- Q906570 wikiPageWikiLink Q7226087.
- Q906570 wikiPageWikiLink Q7249512.
- Q906570 wikiPageWikiLink Q769143.
- Q906570 wikiPageWikiLink Q9454631.
- Q906570 comment "Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of the functional ribosome around the start codon and also provide regulatory mechanisms in translation initiation. Several initiation factors form a complex with the small 40S ribosomal subunit and Met-tRNAiMet called the 43S preinitation complex (PIC).".
- Q906570 label "Eukaryotic initiation factor".