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- Q903909 abstract "Niemann-Pick C1-Like 1 (NPC1L1) is a gene associated with NPC1 which mutation results in Niemann-Pick disease. It codes for Niemann-Pick C1-like protein 1, found on the gastrointestinal tract epithelial cells as well as in hepatocytes. Specifically, it appears to bind to a critical mediator of cholesterol absorption.The drug ezetimibe blocks the NPC1L1 causing a reduction in cholesterol absorption, resulting in a blood cholesterol reduction of between 15-20%. Polymorphic variations in NPC1L1 gene could be associated with non-response to ezetimibe treatment.NPC1L1 has been shown to be an accessory receptor for Hepatitis C virus entry into cells, and thus ezetimibe might be used as a therapeutic strategy".
- Q903909 arm "p".
- Q903909 band "13".
- Q903909 chromosome "7".
- Q903909 entrezgene "29881".
- Q903909 hgncid "7898".
- Q903909 omim "608010".
- Q903909 refseq "NM_013389".
- Q903909 symbol "NPC1L1".
- Q903909 uniprot "Q9UHC9".
- Q903909 wikiPageWikiLink Q1419931.
- Q903909 wikiPageWikiLink Q41301.
- Q903909 wikiPageWikiLink Q417997.
- Q903909 wikiPageWikiLink Q6431240.
- Q903909 wikiPageWikiLink Q708693.
- Q903909 wikiPageWikiLink Q827450.
- Q903909 arm "p".
- Q903909 band "13".
- Q903909 chromosome "7".
- Q903909 entrezgene "29881".
- Q903909 hgncid "7898".
- Q903909 name "NPC1 -like 1".
- Q903909 omim "608010".
- Q903909 refseq "NM_013389".
- Q903909 symbol "NPC1L1".
- Q903909 uniprot "Q9UHC9".
- Q903909 type Biomolecule.
- Q903909 type Protein.
- Q903909 type Thing.
- Q903909 type Q206229.
- Q903909 type Q8054.
- Q903909 comment "Niemann-Pick C1-Like 1 (NPC1L1) is a gene associated with NPC1 which mutation results in Niemann-Pick disease. It codes for Niemann-Pick C1-like protein 1, found on the gastrointestinal tract epithelial cells as well as in hepatocytes. Specifically, it appears to bind to a critical mediator of cholesterol absorption.The drug ezetimibe blocks the NPC1L1 causing a reduction in cholesterol absorption, resulting in a blood cholesterol reduction of between 15-20%.".
- Q903909 label "NPC1L1".
- Q903909 name "NPC1 (Niemann-Pick disease, type C1, gene)-like 1".