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- Q864868 subject Q6585528.
- Q864868 subject Q8934832.
- Q864868 abstract "Bone marrow suppression or myelotoxicity (adjective myelotoxic) or myelosuppression is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes). Bone marrow suppression is a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine. The risk is especially high in cytotoxic chemotherapy for leukemia.Non-steroidal anti-inflammatory drugs, in some rare instances, may also cause bone marrow suppression.The decrease in blood cell counts does not occur right at the start of chemotherapy because the drugs do not destroy the cells already in the bloodstream (these are not dividing rapidly). Instead, the drugs affect new blood cells that are being made by the bone marrow.When myelosuppression is severe, it is called myeloablation.Because the bone marrow is the manufacturing center of blood cells, the suppression of bone marrow activity causes a deficiency of blood cells. This condition can rapidly lead to life-threatening infection, as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as leading to anaemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets.Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. In immunocompromised patients, B19 infection may persist for months, leading to chronic anemia with B19 viremia due to chronic marrow suppression.Thiazide diuretics can also lead to bone marrow suppression as an adverse effect.".
- Q864868 wikiPageWikiLink Q101026.
- Q864868 wikiPageWikiLink Q1059.
- Q864868 wikiPageWikiLink Q10876.
- Q864868 wikiPageWikiLink Q12187.
- Q864868 wikiPageWikiLink Q1435822.
- Q864868 wikiPageWikiLink Q1472.
- Q864868 wikiPageWikiLink Q14863119.
- Q864868 wikiPageWikiLink Q166231.
- Q864868 wikiPageWikiLink Q187255.
- Q864868 wikiPageWikiLink Q188724.
- Q864868 wikiPageWikiLink Q18939.
- Q864868 wikiPageWikiLink Q21163330.
- Q864868 wikiPageWikiLink Q29496.
- Q864868 wikiPageWikiLink Q3269441.
- Q864868 wikiPageWikiLink Q37187.
- Q864868 wikiPageWikiLink Q420553.
- Q864868 wikiPageWikiLink Q42395.
- Q864868 wikiPageWikiLink Q5445.
- Q864868 wikiPageWikiLink Q546523.
- Q864868 wikiPageWikiLink Q641307.
- Q864868 wikiPageWikiLink Q6585528.
- Q864868 wikiPageWikiLink Q665843.
- Q864868 wikiPageWikiLink Q808.
- Q864868 wikiPageWikiLink Q837174.
- Q864868 wikiPageWikiLink Q8934832.
- Q864868 wikiPageWikiLink Q933694.
- Q864868 wikiPageWikiLink Q974135.
- Q864868 comment "Bone marrow suppression or myelotoxicity (adjective myelotoxic) or myelosuppression is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes). Bone marrow suppression is a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine.".
- Q864868 label "Bone marrow suppression".