Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q834280> ?p ?o }
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- Q834280 abstract "Bupropion or bupropion hydrochloride, also known formerly as amfebutamone, is a medication primarily used as an antidepressant and smoking cessation aid. It is marketed as Wellbutrin and Zyban among other trade names. It is one of the most frequently prescribed antidepressants in the United States and Canada, although in many English-speaking countries, including the United Kingdom, Australia and New Zealand, this is an off-label use. Bupropion is taken in tablet form and is available only by prescription in most countries. Chemically, bupropion is in the aminoketone family.Bupropion serves as an atypical antidepressant different from most commonly prescribed antidepressants such as selective serotonin reuptake inhibitors (SSRIs). It is an effective antidepressant on its own, but is also popular as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. In comparison to many other antidepressants, it does not cause as much weight gain or sexual dysfunction. The most important side effect is an increase in risk for epileptic seizures, which caused the drug to be withdrawn from the market for some time and then caused the recommended dosage to be reduced.Bupropion is known to affect several different biological targets, and its mechanism of action is only partly understood. It has been widely described in the literature as a norepinephrine-dopamine reuptake inhibitor (NDRI), and is also a nicotinic antagonist. However, the picture may be more complicated than this, as bupropion does not appear to have significant dopaminergic actions in humans under normal clinical circumstances. Chemically, bupropion belongs to the class of aminoketones and is similar in structure to stimulants such as cathinone and amfepramone, and to phenethylamines in general.Bupropion was synthesized by Nariman Mehta and patented by Burroughs Wellcome in 1969, which later became part of what is now GlaxoSmithKline. It was first approved for clinical use in the United States in 1989. It was originally called by the generic name amfebutamone, before being renamed in 2000. Its chemical name is 3-chloro-N-tert-butyl-β-ketoamphetamine. It is a substituted cathinone (β-ketoamphetamine), and by extension, a substituted amphetamine.".
- Q834280 atcPrefix "N06".
- Q834280 atcSuffix "AX12".
- Q834280 casNumber "34841-39-9".
- Q834280 chEBI "3219".
- Q834280 drugbank "DB01156".
- Q834280 fdaUniiCode "01ZG3TPX31".
- Q834280 iupacName "(±)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one".
- Q834280 pubchem "444".
- Q834280 thumbnail Bupropion_1.svg?width=300.
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- Q834280 wikiPageExternalLink www.wellbutrin-xl.com.
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