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- Q7941535 subject Q8747094.
- Q7941535 subject Q9089708.
- Q7941535 abstract "The von Willebrand factor is a large multimeric glycoprotein found in blood plasma. Mutant forms are involved in the aetiology of bleeding disorders. In von Willebrand factor, the type A domain (vWF) is the prototype for a protein superfamily. The vWF domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands. A number of human diseases arise from mutations in VWA domains. Secondary structure prediction from 75 aligned vWF sequences has revealed a largely alternating sequence of alpha-helices and beta-strands. Fold recognition algorithms were used to score sequence compatibility with a library of known structures: the vWF domain fold was predicted to be a doubly wound, open, twisted beta-sheet flanked by alpha-helices. 3D structures have been determined for the I-domains of integrins CD11b (with bound magnesium) and CD11a (with bound manganese). The domain adopts a classic alpha/beta Rossmann fold and contains an unusual metal ion coordination site at its surface. It has been suggested that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. The residues constituting the MIDAS motif in the CD11b and CD11a I-domains are completely conserved, but the manner in which the metal ion is coordinated differs slightly.".
- Q7941535 symbol "VWA".
- Q7941535 thumbnail PDB_1lfa_EBI.jpg?width=300.
- Q7941535 wikiPageWikiLink Q14863678.
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- Q7941535 wikiPageWikiLink Q18033059.
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- Q7941535 wikiPageWikiLink Q18036498.
- Q7941535 wikiPageWikiLink Q18036499.
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- Q7941535 wikiPageWikiLink Q5145895.
- Q7941535 wikiPageWikiLink Q8747094.
- Q7941535 wikiPageWikiLink Q9089708.
- Q7941535 symbol "VWA".
- Q7941535 type Biomolecule.
- Q7941535 type Protein.
- Q7941535 type Thing.
- Q7941535 type Q206229.
- Q7941535 type Q8054.
- Q7941535 comment "The von Willebrand factor is a large multimeric glycoprotein found in blood plasma. Mutant forms are involved in the aetiology of bleeding disorders. In von Willebrand factor, the type A domain (vWF) is the prototype for a protein superfamily. The vWF domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins.".
- Q7941535 label "Von Willebrand factor type A domain".
- Q7941535 depiction PDB_1lfa_EBI.jpg.