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- Q7860877 subject Q9089708.
- Q7860877 abstract "In molecular biology, the type IV collagen C4 domain (or collagen IV NC1 domain) is a duplicated domain present at the C-terminus of type IV collagens. Each type IV collagen contains a long triple-helical collagenous domain flanked by a short 7S domain of 25 amino acids and a globular non-collagenous C4 domain of ~230 amino acids at the N and C terminus, respectively. In protomer assembly, the C4 domains of three chains interact, forming an C4 trimer, to select and register chains for triple helix formation. In network assembly, the C4 trimers of two protomers interact, forming a C4 hexamer structure, to select and connect protomers.The collagen IV C4 domain contains 12 cysteines, and all of them are involved in disulphide bonds. It folds into a tertiary structure with predominantly beta-strands. The collagen IV C4 domain is composed of two similarly folded subdomains stabilised by 3 intrachain dissulphide bonds involving the following pairs: C1-C6, C2-C5, and C3-C4. Each subdomain represents a compact disulphide-stabilised triangular structure, from which a finger-like hairpin loop projects into an incompletely formed six-stranded beta-sheet of an adjacent subdomain of the same or of an adjacent chain clamping the subdomains tightly together.".
- Q7860877 symbol "C4".
- Q7860877 thumbnail PDB_1li1_EBI.jpg?width=300.
- Q7860877 wikiPageWikiLink Q1230226.
- Q7860877 wikiPageWikiLink Q15712714.
- Q7860877 wikiPageWikiLink Q186474.
- Q7860877 wikiPageWikiLink Q283449.
- Q7860877 wikiPageWikiLink Q3267527.
- Q7860877 wikiPageWikiLink Q418900.
- Q7860877 wikiPageWikiLink Q7251510.
- Q7860877 wikiPageWikiLink Q7860610.
- Q7860877 wikiPageWikiLink Q8066.
- Q7860877 wikiPageWikiLink Q847556.
- Q7860877 wikiPageWikiLink Q898273.
- Q7860877 wikiPageWikiLink Q898483.
- Q7860877 wikiPageWikiLink Q9089708.
- Q7860877 symbol "4.0".
- Q7860877 type Biomolecule.
- Q7860877 type Protein.
- Q7860877 type Thing.
- Q7860877 type Q206229.
- Q7860877 type Q8054.
- Q7860877 comment "In molecular biology, the type IV collagen C4 domain (or collagen IV NC1 domain) is a duplicated domain present at the C-terminus of type IV collagens. Each type IV collagen contains a long triple-helical collagenous domain flanked by a short 7S domain of 25 amino acids and a globular non-collagenous C4 domain of ~230 amino acids at the N and C terminus, respectively.".
- Q7860877 label "Type IV collagen C4 domain".
- Q7860877 depiction PDB_1li1_EBI.jpg.